NameAyala Gómez, Antonio
DepartmentBioquímica y Biología Molecular
Knowledge areaBioquímica y Biología Molecular
Professional categoryCatedrático de Universidad
E-mailRequest
           
  • No. publications

    42

  • No. visits

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Neutrophil-lymphocyte ratio and update conclusions from a 2-year double-blind rct testing fermented papaya preparation in healthy middle-aged/elderly subjects

Lorenzetti, Aldo; Ayala Gómez, Antonio; He, Fang; Aperio, Cristiana; Haghshenas, Leila; Osato, Maki; Marotta, Francesco (Functional Food Center, 2024)
Background:T his study represents the second part of a 2-year interventional study in middle-aged /elderly healthy subjects ...
Article
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The Emerging Role of Senotherapy in Cancer: A Comprehensive Review

Malayaperumal, Sarubala; Marotta, Francesco; Kumar, Makalakshmi Murali; Somasundaram, Indumathi; Ayala Gómez, Antonio; Muñoz Pinto, Mario Faustino; Banerjee, Antara; Pathak, Surajit (MDPI, 2023)
Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. ...
Article
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Interim report from a 2-year double-blind RCT testing fermented papaya preparation on immune enhancement, endothelial health and QOL in elderly adults

Lorenzetti, Aldo; Osato, Maki; He, Fang; Aperio, Cristiana; Ayala Gómez, Antonio; Rasulova, Saida; Barbagallo, Mario (2023)
profile, and endothelial cell dysfunction. Indeed, increased generation of free radicals as well as immunosenescence are ...
Final Degree Project
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Mecanismos moleculares del efecto antienvejecimiento del ejercicio físico

Aceituno Izquierdo, Irene; Ayala Gómez, Antonio (2022)
El envejecimiento es un proceso natural y gradual que se da en todos los seres vivos. Debido al aumento de la esperanza ...
Article
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The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma

Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Rosso, Marisa; Medina, Rafael; Coveñas, Rafael; Ayala Gómez, Antonio; Muñoz, Miguel (Hindawi, 2022)
Background. Glioblastoma or glioma is the most common malignant brain tumor. Patients have a prognosis of approximately ...
Article
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Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice

Gopi, Janani; Marotta, Francesco; Sriramulu, Sushmitha; Banerjee, Antara; Kanna, N.R. Rajesh; Palani, Vignesh; Ayala Gómez, Antonio; He, Fang; Vijayashree, R.; Pathak, Surajit (Functional Food Center Inc., 2022)
Background: This study deals with the induction of lipopolysaccharide induced inflammation in animal model and treating ...
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Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells

Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Marotta, Francesco; Barbagallo, M.; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Hindawi, 2020)
A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem ...
Article
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Rosmarinus officinalis l. (rosemary): An ancient plant with uses in personal healthcare and cosmetics

González Minero, Francisco José; Bravo Díaz, Luis; Ayala Gómez, Antonio (Multidisciplinary Digital Publishing Institute (MDPI), 2020)
This work is a bibliographical review of rosemary (Rosmarinus officinalis) that focuses on the application of derivatives ...
Patent. Invention
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Kit y método de cuantificación de la toxicidad en neuronas de la corteza cerebral para la detección de enfermedades neurodegenerativas

Núñez Abades, Pedro Antonio; Carrascal Moreno, María Livia; Pardilla Díaz, Ricardo; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio (Oficina Española de Patentes y Marcas (OEPM), 2019)
La presente invención escribe un método electrofisiológico y un kit consistente en una concentración de 10 µM de hidroperóxido ...
Article
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Physical exercise and myokines

Zumárraga Franco, Javier; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Cano Rodríguez, María Mercedes (Spanish Society of Anti-Aging Medicine and Longevity, 2019)
Among the types of muscles present in the body is skeletal muscle, which is the one that allows the development of physical ...
Article
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Dysregulation of the Hippo Pathway Signaling in Aging and Cancer

Yeung, Yiu To; Guerrero Castilla, Angelica; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Argüelles Castilla, Sandro (Elsevier, 2019)
Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life ...
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Advantages and Disadvantages of Apoptosis in the Aging Process

Argüelles Castilla, Sandro; Guerrero Castilla, Angélica; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio (Wiley-Blackwell, 2019)
Researchers cannot predict as yet how long a human being can live. Life expectancy has been steadily increasing in the ...
Article
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Cell Tracking, Survival, and Differentiation Capacity of Adipose-Derived Stem Cells After Engraftment in Rat Tissue

Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Guzmán Chozas, Matías; Guillén Sans, Remedios; Franco, Jaime M.; Pintor Toro, José A.; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Wiley-Blackwell, 2018)
Adipose tissue is an important source of adipose derived stem cells (ADSCs). These cells have the potential of being used ...
Final Degree Project
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La importancia del sueño en el mantenimiento de la salud

Jiménez López, Ylenia; Ayala Gómez, Antonio (2017)
Los seres humanos pasan aproximadamente alrededor de un tercio de sus vidas dormidos, sin embargo la mayoría de las personas ...
Article
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Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis

Uemura, Junji; Nagpal, Ravinder K.; Zerbinati, Nicola; Marcellino, Massimiliano; Mohania, Dheeraj; Marotta, Francesco; He, Fang; Ayala Gómez, Antonio; Kasugai, Yasuhiro; Catanzaro, Roberto (Spandidos Publications, 2017)
Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. ...
Article
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Immunolocalization of Substance P and NK-1 Receptor in ADIPOSE Stem Cells

Muñoz, Miguel; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio (Wiley-Blackwell, 2017)
Substance P (SP) is a neuropeptide belonging to the thachykinin peptide family. SP, after binding to its receptor, the ...
Article
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Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide

Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Cano Rodríguez, María Mercedes; Marotta, Francesco; Ayala Gómez, Antonio (Wiley-Blackwell, 2017)
We studied the alterations of Elongation Factor 2 (eEF2) in the pineal gland of aged rats as well as the possible protective ...
Article
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Hialuronic acid in sking aging

Serres, José; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Ayala Gómez, Antonio (Spanish Society of Anti-Aging Medicine and Longevity, 2016)
Article
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Time and dose dependent effects of oxidative stress induced by cumene hydroperoxide in neuronal excitability of rat motor cortex neurons

Pardillo Díaz, Ricardo; Carrascal Moreno, María Livia; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Núñez Abades, Pedro Antonio (Elsevier, 2016)
It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration ...
PhD Thesis
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Estudio de la viabilidad y diferenciación de las células madre mesenquimales de tejido adiposo en condiciones de estrés oxidativo y envejecimiento. Posibilidad de su uso terapéutico e influencia del factor de elongación 2

Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Guzmán Chozas, Matías; Guillen Sans, Remedios (2016)
The present thesis is a compilation of several experiments about the use of adiposederived mesenchymal stem cells (ADSCs) ...
Final Degree Project
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Efecto de la suplementación nutricional sobre algunos marcadores utilizados en las consultas antienvejecimiento

Tejero Vargas, Francisco Javier; Ayala Gómez, Antonio (2016)
Hoy en día las personas se preocupan más por su salud, prevenir las enfermedades y controlar el envejecimiento. El ...
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Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus

Sánchez Hidalgo, Ana C.; Muñoz Pinto, Mario Faustino; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Stowell, Rianne; Ayala Gómez, Antonio; Machado, Alberto; Venero Recio, José Luis; Martínez de Pablos, Rocío (Elsevier, 2016)
The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and ...
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Treatment with mesenchymal stem cells in an animal model of parkinson´s disease

Naranjo, José Ángel; Ayala Gómez, Antonio; Cano Rodríguez, María Mercedes; Argüelles Castilla, Sandro; Ruiz, Victoria; Muñoz Pinto, Mario Faustino (Federation of Anti-Aging Medicine Societies, 2015)
PhD Thesis
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Efecto del tratamiento con metformina en el sistema dopaminérgico nigroestriado: posible implicación en la enfermedad de parkinson.

Ismaiel, Afrah Abdul; Martínez de Pablos, Rocío; Cano Rodríguez, María Mercedes; Espinosa Oliva, Ana María; Ayala Gómez, Antonio (2014)
La enfermedad de Parkinson (EP) es un desorden relacionado con la edad caracterizado por la degeneración progresiva de las ...
Article
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A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

Chui, D. H.; Marcellino, Massimiliano; Marotta, Francesco; Sweed, H.; Solimene, U.; Vignali, A. I.; Ayala Gómez, Antonio; Zerbinati, Nicola (JCDR, 2014)
Introduction: The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown ...
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Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

Ayala Gómez, Antonio; Muñoz Pinto, Mario Faustino; Argüelles Castilla, Sandro (Hindawi Publishing Corporation, 2014)
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids ...
Article
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Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions

Argüelles Castilla, Sandro; Camandola, Simonetta; Cutler, Roy G.; Ayala Gómez, Antonio (Elsevier, 2013)
Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) ...
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Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress

Argüelles Castilla, Sandro; Camandola, Simonetta; Hutchison, Emmette R.; Cutler, Roy G.; Ayala Gómez, Antonio (Eslsevier, 2013)
Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls ...
Article
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Folic acid supplementation: some practical aspects

Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala Gómez, Antonio; Argüelles Castilla, Sandro (Federation of Anti-Aging Medicine Societies, 2012)
Since 1956, when Harman first postulated the free radical theory of aging, numerous studies have been carried out to test ...
Article
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In vitro and in Vivo Protection by Melatonin Against the Decline of Elongation Factor-2 Caused by Lipid Peroxidation: Preservation of Protein Synthesis

Argüelles Castilla, Sandro; Muñoz Pinto, Mario Faustino; Cano Rodríguez, María Mercedes; Machado Quintana, Alberto; Ayala Gómez, Antonio (Wiley-Blackwell, 2012)
As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of ...
Chapter of Book
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Assessment of the General Oxidant Status of Individuals in Non-Invasive Samples

Argüelles Castilla, Sandro; Cano Rodríguez, María Mercedes; Muñoz Pinto, Mario Faustino; Ayala, Rafael; Ismaiel, Afrah; Ayala Gómez, Antonio (IntechOpen, 2012)
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Potential use of adipose tissue stem cells in the control of aging

Muñoz Pinto, Mario Faustino; Zurita Díaz, Francisco; Argüelles Castilla, Sandro; Vázquez, Rocío; Serres, José; Guzmán Chozas, Matías; Guillén Sanz, Remedios; Rodríguez Gómez, José Antonio; Cortés, José Luis; Muñoz Franco, Jaime; Pintor Toro, José Antonio; Cano Rodríguez, María Mercedes; Ayala Gómez, Antonio (Federation of Anti-Aging Medicine Societies, 2012)
Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we ...
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Mitochondrial toxins and neurodegenerative diseases

Ayala Gómez, Antonio; Venero Recio, José Luis; Cano, Josefina; Machado, Alberto (IMR Press, 2007)
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in ...
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Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study

Abilés, Jimena; Pérez de la Cruz, Antonio Jesús; Castaño, José García; Rodríguez Elvira, Manuel; Aguayo, Eduardo; Moreno Torres, Rosario; Llopis, Juan Emilio; Aranda, Pilar; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Machado Quintana, Alberto; Planells, Elena María (Springer Science + Business Media, 2006)
Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species ...
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Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex

Martínez de Pablos, Rocío; Fernández Villarán, Ruth; Argüelles Castilla, Sandro; Herrera Carmona, Antonio José; Venero Recio, José Luis; Ayala Gómez, Antonio (Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because ...
PhD Thesis
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Estudio de los efectos producidos por la administración crónica de manganeso: implicación de la ingesta de hierro

Sánchez Hidalgo, Mary Cruz; Cano García, Josefina; Ayala Gómez, Antonio; Machado Quintana, Alberto (2005)
En la tesis titulada "Estudio de los efectos producidos por la administración crónica de manganeso: implicación de la ...
PhD Thesis
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Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging

Piwien Pilipuk, Graciela; Ayala Gómez, Antonio; Machado de la Quintana, Alberto; Galigniana, Mario D. (American Society for Biochemistry and Molecular Biology, 2002)
Acute and chronic treatments of mice with the gluta- thione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired ...
PhD Thesis
PhD Thesis
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Sintesis de proteinas y envejecimiento: papel de los radicales libres

Bougria, Mohammed; Machado Quintana, Alberto; Ayala Gómez, Antonio; Parrado Rubio, Juan (1997)
El principal objetivo de este trabajo es estudiar el mecanismo por el cual la síntesis de proteínas disminuye durante el ...
Article
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Effect of oxidative stress, produced by cumene hydroperoxide, on the various steps of protein synthesis. Modifications of elongation factor-2

Ayala Gómez, Antonio; Parrado Rubio, Juan; Bougria, Mohammed; Machado Quintana, Alberto (American Society for Biochemistry and Molecular Biology, 1996)
We have studied the effect of oxidative stress on protein synthesis in rat liver. Cumene hydroperoxide (CH) was used as ...
PhD Thesis
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Estudio de la regulación a largo plazo de las enzimas productoras de NADPH implicación del requerimiento de NADPH

Ayala Gómez, Antonio; Machado Quintana, Alberto (1986)
El NADPH es uno de los principales productos finales de los procesos metabólicos, siendo al mismo tiempo sustrato de importantes reacciones metabólicas y de destoxificación.|