Artículo
Dysregulation of the Hippo Pathway Signaling in Aging and Cancer
Autor/es | Yeung, Yiu To
Guerrero Castilla, Angelica Cano Rodríguez, María Mercedes Muñoz Pinto, Mario Faustino Ayala Gómez, Antonio Argüelles Castilla, Sandro |
Departamento | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2019 |
Fecha de depósito | 2024-01-26 |
Publicado en |
|
Resumen | Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy. In the near future, researchers will have to put even more effort into fighting these new ... Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy. In the near future, researchers will have to put even more effort into fighting these new challenges, one of which will be prevention of cancer while continuing to improve the aging process through this increased life expectancy. In the last few decades, relevance of the Hippo pathway on cancer has become an important study since it is a major regulator of organ size control and proliferation. However, its deregulation can induce tumors throughout the body by regulating cell proliferation, disrupting cell polarity, releasing YAP and TAZ from the Scribble complexes and facilitating survival gene expression via activation of TEAD transcription factors. This pathway is also involved in some of the most important mechanisms that control the aging processes, such as the AMP-activated protein kinase and sirtuin pathways, along with autophagy and oxidative stress response/antioxidant defense. This could be the link between two tightly connected processes that could open a broader range of targeted molecular therapies to fight aging and cancer. Therefore, available knowledge of the processes involved in the Hippo pathway during aging and cancer must necessarily be well understood. |
Agencias financiadoras | Universidad de Sevilla |
Identificador del proyecto | USE-14793-G |
Cita | Yeung, Y.T., Guerrero Castilla, A., Cano Rodríguez, M.M., Muñoz Pinto, M.F., Ayala Gómez, A. y Argüelles Castilla, S. (2019). Dysregulation of the Hippo Pathway Signaling in Aging and Cancer. Pharmacological Research, 143, 151-165. https://doi.org/10.1016/j.phrs.2019.03.018. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Dysregulation of the Hippo.pdf | 1.230Mb | [PDF] | Ver/ | |