Artículo
Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases
Autor/es | Ortiz Cerda, Tamara Andrea
Argüelles Arias, Federico Begines Ruiz, Belén García Montes, Josefa María Pereira Yáñez, Alejandra Victoriano Rojas, Montserrat Vázquez Román, María Victoria Pérez Bernal, Juan Luis Callejón Fernández, Raquel María Miguel Rodríguez, Manuel de Alcudia Cruz, Ana |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica Universidad de Sevilla. Departamento de Química Analítica Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal |
Fecha de publicación | 2021-05 |
Fecha de depósito | 2021-06-28 |
Publicado en |
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Resumen | The best conservation method for native Chilean berries has been investigated in combination with an implemented large-scale extract of maqui berry, rich in total polyphenols and anthocyanin to be tested in intestinal ... The best conservation method for native Chilean berries has been investigated in combination with an implemented large-scale extract of maqui berry, rich in total polyphenols and anthocyanin to be tested in intestinal epithelial and immune cells. The methanolic extract was obtained from lyophilized and analyzed maqui berries using Folin–Ciocalteu to quantify the total polyphenol content, as well as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and oxygen radical absorbance capacity (ORAC) to measure the antioxidant capacity. Determination of maqui’s anthocyanins profile was performed by ultra-high-performance liquid chromatography (UHPLC-MS/MS). Viability, cytotoxicity, and percent oxidation in epithelial colon cells (HT-29) and macrophages cells (RAW 264.7) were evaluated. In conclusion, preservation studies confirmed that the maqui properties and composition in fresh or frozen conditions are preserved and a more efficient and convenient extraction methodology was achieved. In vitro studies of epithelial cells have shown that this extract has a powerful antioxidant strength exhibiting a dose-dependent behavior. When lipopolysaccharide (LPS)-macrophages were activated, noncytotoxic effects were observed, and a relationship between oxidative stress and inflammation response was demonstrated. The maqui extract along with 5-aminosalicylic acid (5-ASA) have a synergistic effect. All of the compiled data pointed out to the use of this extract as a potential nutraceutical agent with physiological benefits for the treatment of inflammatory bowel disease (IBD). |
Identificador del proyecto | 2018/00000802-CTS949
PID2019-109371GB-I00 2017/FQM-135 |
Cita | Ortiz Cerda, T.A., Argüelles Arias, F., Begines Ruiz, B., García Montes, J.M., Pereira Yáñez, A., Victoriano Rojas, M.,...,Alcudia Cruz, A. (2021). Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases. Antioxidants, 10 (6), 843. |
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