• Article
  

  Spanish National Registry of Major Osteoporotic Fractures (REFRA) seen at Fracture Liaison Services (FLS): objectives and quality standards 

  Montoya García, María José; Carbonell Abella, Cristina; Cancio Trujillo, José Manuel; Moro Álvarez, María Jesús; Izquierdo Avino, Rafael; Nogues, Xavier; Giner García, Mercedes (SPRINGER, 2022)

  Summary REFRA-FLS is a new registry in Spain aimed at identifying individuals over 50 years of age with a fragility ...

• Article
  

  Histopathological Features of Pendred Syndrome Thyroids Align with Differences in the Expression of Thyroid‑Specific Markers, Apical Iodide Transporters, and Ciliogenesis Process 

  Vázquez Román, María Victoria; Cameselle Teijeiro, J. M.; Fernández-Santos, José María; Ríos Moreno, M. J.; Loidi, L.; Ortiz Cerda, Tamara Andrea; Martín Lacave, Inés María (HUMANA PRESS INC, 2022)

  Pendred syndrome (PDS) is an autosomal recessive disorder caused by mutations in the gene that encodes pendrin. Pendred ...

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  Circulating Osteogenic Progenitor Cells Enhanced with Teriparatide or Denosumab Treatment 

  Giner García, Mercedes; Vázquez Gámez, María de los Ángeles; Miranda, María José; Bocio-Núñez, Jesús; Olmo-Montes, Francisco Jesús; Rico Corral, Miguel Ángel; Colmenero, Miguel Ángel; Montoya García, María José (MDPI, 2022)

  Circulating osteogenic precursor (COP) cells are peripheral blood cells with a capacity for osteogenesis. The objective ...

• Article
  

  An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis 

  García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Andrés León, Eduardo; Sánchez-Molina, Sara; Rodríguez-Núñez, Pablo; Morón, Francisco J.; Hajji, Nabil; Mackintosh, Carlos; Álava Casado, Enrique de (Public Library of Science, 2020)

  The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ...

• Article
  

  Osteoblastic cell behavior and gene expression related to bone metabolism on different titanium surfaces 

  Velasco-Ortega, Eugenio; Fos-Parra, Isabel; Cabanillas Balsera, Daniel; Gil, Javier; Ortiz García, Iván; Giner García, Mercedes; Bocio-Núñez, Jesús; Montoya García, María José; Jiménez Guerra, Álvaro (MDPI, 2023-02-09)

  The surface topography of titanium dental implants has a great influence on osseointegration. In this work, we try to ...

• Article
  

  Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma 

  Marchetto, Aruna; Ohmura, Shunya; Orth, Martin F.; Knott, Maximilian M.L.; Colombo, Maria V.; Romero Pérez, Laura (Nature Publishing Group, 2020)

  Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic ...

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  Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma 

  Rodríguez-Núñez, Pablo; Romero Pérez, Laura; Amaral, Ana T.; Puerto-Camacho, Pilar; Jordán, Carmen; Marcilla, David; Álava Casado, Enrique de; Díaz-Martín, Juan (Wiley, 2020)

  YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ...

• Article
  

  A Quantitative Digital Analysis of Tissue Immune Components Reveals an Immunosuppressive and Anergic Immune Response with Relevant Prognostic Significance in Glioblastoma 

  Idoate Gastearena, Miguel Ángel; López Janeiro, Álvaro; Lecumberri Aznarez, Arturo; Arana Iñiguez, Iñígo; Guillén Grima, Francisco (MDPI, 2022)

  Objectives: Immunostimulatory therapies using immune checkpoint blockers show clinical activity in a subset of glioblastoma ...

• Article
  

  Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial 

  Martín Broto, Javier; Hindi, Nadia; Grignani, Giovanni; Martínez Trufero, Javier; Redondo, Andrés; Valverde, Claudia; Encinas Tobajas, Víctor; Álava Casado, Enrique de; López Martín, José A. (BMJ Journals, 2020)

  Background: Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity ...

• Article
  

  Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors 

  Pignata, Laura; Palumbo, Orazio; Cerrato, Flavia; Acurzio, Basilia; Álava Casado, Enrique de; Roma, Josep; Verde, Gaetano (MDPI, 2020)

  The embryonal renal cancer Wilms tumor (WT) accounts for 7% of all children’s malignancies. Its most frequent molecular ...

• Article
  

  An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma 

  Shulman, David S.; Whittle, Sarah B.; Surdez, Didier; Bailey, Kelly M.; Álava Casado, Enrique de; Yustein, Jason T.; Grohar, Patrick J. (Nature Research, 2022-09-17)

  The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized ...

• Article
  

  Evidence for Oxidative Pathways in the Pathogenesis of PD Are Antioxidants Candidate Drugs to Ameliorate Disease Progression 

  Leathem, Alexander; Ortiz Cerda, Tamara Andrea; Dennis, Joanne M.; Witting, Paul K. (MDPI, 2022-06-22)

  Parkinson’s disease (PD) is a progressive neurodegenerative disorder that arises due to a complex and variable interplay ...

• Article
  

  Best Practice Framework of Fracture Liaison Services in Spain and their coordination with Primary Care 

  Naranjo, A.; Ojeda, S.; Giner García, Mercedes; Balcells-Oliver, M.; Canals, L.; Cancio, J. M.; Montoya García, María José; Prieto-Alhambra, D. (2020)

  Summary The coordination of Fracture Liaison Services (FLS) with Primary Care (PC) is necessary for the continuity of care ...

• Article
  

  RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis 

  Sánchez Molina, Sara; Figuerola Bou, Elisabet; Blanco, Enrique; Sánchez Jiménez, María; Táboas, Pablo; Gómez, Soledad; Álava Casado, Enrique de (American Association for the Advancement of Science, 2020)

  Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal ...

• Article
  

  Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions 

  Puerto-Camacho, Pilar; Díaz-Martín, Juan; Olmedo Pelayo, Joaquín; Bolado Carrancio, Alfonso; Salguero-Aranda, Carmen; Jordán-Pérez, Carmen; Álava Casado, Enrique de (MDPI ; MDPI AG, 2022)

  Abstract: Endoglin (ENG) is a mesenchymal stem cell (MSC) marker typically expressed by active endothelium. This transmembrane ...

• Article
  

  Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology 

  Remon, J.; García-Campelo, R.; Álava Casado, Enrique de; Vera, R.; Rodríguez-Peralto, J. L.; Rodríguez-Lescure, Á (Springer, 2020)

  The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing ...

• Article
  

  Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials 

  Hontecillas Prieto, Lourdes; Flores Campos, Rocío; Silver, Andrew; Álava Casado, Enrique de; Hajji, Nabil; García-Domínguez, Daniel J. (Frontiers Media S.A., 2020)

  Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ...

• Article
  

  A mobile app using therapeutic exercise and education for self-management in patients with hand rheumatoid arthritis: a randomized controlled trial protocol 

  Rodríguez Sánchez Laulhé, P.; Luque Romero, Luis Gabriel; Blanquero, Jesús; Suero Pineda, Alejandro; Biscarri Carbonero, Angela; Barrero García, Francisco José; Heredia Rizo, Alberto Marcos (BMC, 2020)

  Background: Therapeutic exercise is a safe and cost-effective approach to alleviate hand rheumatoid arthritis (RA)- related ...

• Article
  

  Clinical performance evaluation of the Idylla (TM) EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cáncer 

  Delgado-García, Mercedes; Weynand, Birgit; Gómez-Izquierdo, Lourdes; Hernández, María José; Blanco, Ángela María; Varela, Mar; Álava Casado, Enrique de; Biscuola, Michele (BMC, 2020)

  Background: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18-21 is recommended in all patients ...

• Article
  

  Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma 

  Navarro, Natalia; Molist, Carla; Sansa Girona, Júlia; Zarzosa, Patricia; Gallo-Oller, Gabriel; Pons, Guillem; Álava Casado, Enrique de; Roma, Josep (Springer, 2022-10-11)

  The majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological ...

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