Artículo
Immunohistochemical profiling of the ultimobranchial remnants in the rat postnatal thyroid gland
Autor/es | Vázquez Román, María Victoria
Utrilla Alcolea, José Carmelo Fernández-Santos, José María Martín Lacave, Inés María |
Departamento | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2017-05-02 |
Fecha de depósito | 2024-01-12 |
Publicado en |
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Resumen | Ultimobranchial (UB) remnants are a constant presence in the thyroid throughout rat postnatal life; however, the difficulty in identifying the most immature forms from the surrounding thyroid tissue prompted us to search ... Ultimobranchial (UB) remnants are a constant presence in the thyroid throughout rat postnatal life; however, the difficulty in identifying the most immature forms from the surrounding thyroid tissue prompted us to search for a specific marker. With that objective, we applied a panel of antibodies reported to be specific for their human counterpart, solid cell nests (SCNs), using double immunohistochemistry and immunofluorescence. Our results demonstrated that cytokeratin 34βE12 and p63 are highly sensitive markers for the immunohistologic screening of UB-remnants, independently of their maturity or size. Furthermore, rat UB-follicles (UBFs) coincided with human SCNs in the immunohistochemical pattern exhibited by both antigens. In contrast, the pattern displayed for calcitonin and thyroglobulin differs considerably but confirm the hypothesis that rat UB-cells can differentiate into both types of thyroid endocrine cells. This hypothesis agrees with recent findings that thyroid C-cells share an endodermic origin with follicular cells in rodents. We suggest that the persistence of p63-positive undifferentiated cells in UB-remnants may constitute a reservoir of basal/stem cells that persist beyond embryogenesis from which, in certain unknown conditions, differentiated thyroid cells or even unusual tumors may arise. |
Cita | Vázquez Román, M.V., Utrilla Alcolea, J.C., Fernández-Santos, J.M. y Martín Lacave, I.M. (2017). Immunohistochemical profiling of the ultimobranchial remnants in the rat postnatal thyroid gland. Journal of Morphology, 278 (8), 1114-1124. https://doi.org/10.1002/jmor.20698. |
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