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Artículo
Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs
(Wolters Kluwer Health, 2010)
Oxidative therapy is a relatively new anticancer strategy based on the induction of high levels of oxidative stress, achieved by increasing intracellular reactive oxygen species (ROS) and/or by depleting the ...
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Artículo
Clonal patterns in phaeochromocytomas and MEN-2A adrenal medullary hyperplasias: histological and kinetic correlates
(John Wiley & Sons, 2000-06-26)
The relationship among histological features, cell kinetics, and clonality has not been studied in adrenal medullary hyperplasias (AMHs) and phaeochromocytomas (PCCs). Thirty-four PCCs (23 sporadic and 11 MEN-2A (multiple ...
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Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells
(Elsevier, 2017)
Amitriptyline, a tricyclic antidepressant, has been proposed as an antitumoral drug in oxidative therapy. Its pro-apoptotic effects, mediated by high reactive oxygen species generation, have been already described. In ...
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Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis
(NATURE PUBLISHING GROUP, 2013)
Apoptotic microtubule network (AMN) is organized during apoptosis, forming a cortical structure beneath plasma membrane, which has an important role in preserving cell morphology and plasma membrane permeability. The aim ...
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cDNA Sequence and Genomic Structure of the Rat Ret Proto-Oncogene
(Informa Healthcare, 2000-06-01)
The RET proto-oncogene, a member of the Receptor Tyrosine Kinase family, plays a crucial role during the development of the excretory system and the enteric nervous system, as demonstrated by in vivo animal studies and by ...
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Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
(MDPI, 2019)
Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival ...
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Kinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of down-regulated apoptosis in tumor progression
(Springer, 2000-05)
The cell kinetic of prostatic intraepithelial neoplasia (PIN) is poorly understood. Herein we report the kinetic pattern of PIN, both not associated (primary) and associated (secondary) with coexistent invasive carcinoma ...
Artículo
Coenzyme Q(10) Therapy
(KARGER, 2014)
For a number of years, coenzyme Q 10 (CoQ 10 ) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively ...
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Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases
(MDPI, 2021-05)
The best conservation method for native Chilean berries has been investigated in combination with an implemented large-scale extract of maqui berry, rich in total polyphenols and anthocyanin to be tested in intestinal ...