Artículo
Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
Autor/es | Bullón de la Fuente, Beatriz
Miguel Rodríguez, Manuel de Bullon, Pedro Román Malo, Lourdes Victoria |
Director | |
Departamento | Universidad de Sevilla. Departamento de Estomatología Universidad de Sevilla. Citología e Histología Normal y Patológica |
Fecha de publicación | 2019 |
Fecha de depósito | 2019-09-06 |
Publicado en |
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Resumen | Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival ... Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis were treated, and gingival biopsies were obtained. A histological study revealed dense fibrous tissue, basal lamina disruption, and epithelial cell migration into the connective tissue. Fibroblasts were cultured from the father and daughter and compared with those from a healthy control patient. The results of the biochemical analysis showed increased collagen synthesis, reduced antioxidant CoQ10 content, and high levels of lipid peroxidation. Additionally, fibroblasts culture incubation with the oxidant H2O2 increased collagen levels that have been reduced by the addition of the antioxidant CoQ10. We conclude that some fibroblasts metabolic alterations play a significant role in initiating and maintaining persistent fibrotic tissue. Oxidative stress influences the fibroblasts collagen production and could play a particular role in the pathogenesis of hereditary gingival fibromatosis. |
Cita | Bullón Fernández, B., Miguel Rodríguez, M.d., Bullon, P. y Román Malo, L.V. (2019). Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis. Diseases, 7 (2), 1-8. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Fibroblasts Collagen.pdf | 1.666Mb | [PDF] | Ver/ | Fibroblasts Collagen |