Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por título
Mostrando ítems 147-165 de 165
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Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, ...
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TOPORS, a dual E3 ubiquitin and Sumo1 ligase, interacts with 26 S protease regulatory subunit 4, encoded by the PSMC1 gene
(Public Library of Science, 2016)The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of ...
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Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Transcriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa
(Nature Publishing Group, 2016)PRPF31-associated retinitis pigmentosa presents a fascinating enigma: some mutation carriers are blind, while others are ...
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TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling
(Frontiers Media, 2019)Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also ...
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UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
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Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018-07-03)Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is ...
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Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
(BioMed Central, 2017)Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. ...
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VID22 counteracts G-quadruplex-induced genome instability
(Oxford University Press, 2021)Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
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WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ...
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What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
(MDPI, 2021)Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...
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XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
(MDPI, 2022)Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...
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Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
(Cold Spring Harbor Laboratory Press, 2018)R loops are an important source of genome instability, largely due to their negative impact on replication progression. ...
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Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
(Oxford University Press, 2011)Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster ...
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Zn2+ chelation by serum albumin improves hexameric Zn2+ -insulin dissociation into monomers after exocytosis
(Public Library of Science, 2017)β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the ...