Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por título
Mostrando ítems 138-157 de 165
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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity article
(Springer Nature [academic journals on nature.com, 2018)HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small ...
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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
(Frontiers Media S.A., 2020)Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of ...
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Thyroid hormones in diabetes, cancer, and aging
(Wiley, 2020)Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...
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Titanium Surface Characteristics Induce the Specific Reprogramming of Toll-like Receptor Signaling in Macrophages
(MDPI, 2022)Most of the research on titanium-based dental implants (Ti-discs) is focused on how they are able to stimulate the formation ...
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Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
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Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, ...
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TOPORS, a dual E3 ubiquitin and Sumo1 ligase, interacts with 26 S protease regulatory subunit 4, encoded by the PSMC1 gene
(Public Library of Science, 2016)The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of ...
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Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Transcriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa
(Nature Publishing Group, 2016)PRPF31-associated retinitis pigmentosa presents a fascinating enigma: some mutation carriers are blind, while others are ...
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TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling
(Frontiers Media, 2019)Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also ...
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UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
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Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018-07-03)Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is ...
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Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
(BioMed Central, 2017)Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. ...