Artículos (Fisiología Médica y Biofísica)
Recent Submissions
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Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses
(Public Library of Science, 2011-04-29)Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during ...
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Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons
(Elsevier, 2008-02-15)Gene transfer methods for efficient co-expression of exogenous proteins in neurons are crucial tools towards the understanding ...
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Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses
(Lippincott, Williams & Wilkins, 2013-08-07)Neurexins are synaptic plasma membrane proteins encoded by three genes (NRXN1, -2, -3) with alternative promoters. Mutations ...
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A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function
(Elsevier, 2015-09-03)Neuroligins (NLs) are cell-adhesion proteins that regulate synapse formation and function. Neuroligin 1 (NL1) promotes the ...
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Molecular and Cellular Mechanisms of Synaptopathies
(Wiley Open Access, 2017-04-30)Synapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to ...
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Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
(Society for Neuroscience, 2018-01-24)Proteolytic processing of synaptic adhesion components can accommodate the function of synapses to activity-dependent ...
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A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity
(Cell Press, 2023-05-13)Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical ...
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Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
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The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
(Frontiers Media, 2018-03-21)Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ...
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Valor pronóstico de la bioimpedancia eléctrica medida con el dispositivo IVOL en la insuficiencia cardiaca aguda
(Elsevier, 2024)Introducción y objetivos: La evaluación actual de la insuficiencia cardiaca (IC) aguda no permite predecir adecuadamente ...
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Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells
(2016-08-07)Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the ...
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An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
(Wiley, 2024)Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...
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Redox signaling in acute oxygen sensing
(Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals LLC, 2017-09-08)The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction ...
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
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IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner
(Willey, 2022)Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates ...
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The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...
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Genetic divergence and demography of pudu deer (Pudu puda) in five provinces of southern Chile, analyzed through latitudinal and longitudinal ranges
(Pensoft Publishers, 2022)Pudu deer (Pudu puda) is endemic to the temperate rainforests of Chile. Genetic studies at different geographic scales for ...
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Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
(2016-12)Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
(Wiley, 2017-09)Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...