Artículo
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
Autor/es | Haarr, Marianne B.
López López, Óscar Pejov, Ljupcho Fernández-Bolaños Guzmán, José María Lindbäck, Emil Sydnes, Magne O. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-12-15 |
Publicado en |
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Resumen | The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM). |
Identificador del proyecto | CTQ2016-78703-P
FQM134 |
Cita | Haarr, M.B., López López, Ó., Pejov, L., Fernández-Bolaños Guzmán, J.M., Lindbäck, . y Sydnes, M.O. (2020). 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors. ACS Omega, 5 (29), 18507-18514. |
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