Article
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
Author/s | Haarr, Marianne B.
López López, Óscar ![]() ![]() ![]() ![]() ![]() ![]() ![]() Pejov, Ljupcho Fernández-Bolaños Guzmán, José María ![]() ![]() ![]() ![]() ![]() ![]() ![]() Lindbäck, Emil Sydnes, Magne O. |
Department | Universidad de Sevilla. Departamento de Química orgánica |
Publication Date | 2020 |
Deposit Date | 2020-12-15 |
Published in |
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Abstract | The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM). |
Project ID. | CTQ2016-78703-P
![]() FQM134 ![]() |
Citation | Haarr, M.B., López López, Ó., Pejov, L., Fernández-Bolaños Guzmán, J.M., Lindbäck, . y Sydnes, M.O. (2020). 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors. ACS Omega, 5 (29), 18507-18514. |
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