1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Haarr, Marianne B.; López López, Óscar; Pejov, Ljupcho; Fernández-Bolaños Guzmán, José María; Lindbäck,  Emil; Sydnes, Magne O.

doi:10.1021/acsomega.0c02466

Artículo

dc.creator	Haarr, Marianne B.	es
dc.creator	López López, Óscar	es
dc.creator	Pejov, Ljupcho	es
dc.creator	Fernández-Bolaños Guzmán, José María	es
dc.creator	Lindbäck, Emil	es
dc.creator	Sydnes, Magne O.	es
dc.date.accessioned	2020-12-15T09:54:03Z
dc.date.available	2020-12-15T09:54:03Z
dc.date.issued	2020
dc.identifier.citation	Haarr, M.B., López López, Ó., Pejov, L., Fernández-Bolaños Guzmán, J.M., Lindbäck, . y Sydnes, M.O. (2020). 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors. ACS Omega, 5 (29), 18507-18514.
dc.identifier.issn	2470-1343	es
dc.identifier.uri	https://hdl.handle.net/11441/103222
dc.description.abstract	The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).	es
dc.description.sponsorship	España, Dirección General de Investigación (CTQ2016-78703-P)	es
dc.description.sponsorship	Junta de Andalucía (FQM134)	es
dc.format	application/pdf	es
dc.format.extent	7 p.	es
dc.language.iso	eng	es
dc.publisher	American Chemical Society	es
dc.relation.ispartof	ACS Omega, 5 (29), 18507-18514.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Química orgánica	es
dc.relation.projectID	CTQ2016-78703-P	es
dc.relation.projectID	FQM134	es
dc.relation.publisherversion	http://dx.doi.org/10.1021/acsomega.0c02466	es
dc.identifier.doi	10.1021/acsomega.0c02466	es
dc.journaltitle	ACS Omega	es
dc.publication.volumen	5	es
dc.publication.issue	29	es
dc.publication.initialPage	18507	es
dc.publication.endPage	18514	es

Ficheros	Tamaño	Formato	Ver	Descripción
pubao0c02466.pdf	1.017Mb	[PDF]	Ver/Abrir

Este registro aparece en las siguientes colecciones

Artículos (Química Orgánica)

Mostrar el registro sencillo del ítem

Excepto si se señala otra cosa, la licencia del ítem se describe como: Attribution-NonCommercial-NoDerivatives 4.0 Internacional