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Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase

 

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Opened Access Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
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Author: Aguilar Moncayo, Matilde
García Moreno, M. Isabel
Trapero, Ana
Egido Gabás, Meritxell
Llebaria, Amadeu
García Fernández, José Manuel
Ortiz Mellet, Carmen
Department: Universidad de Sevilla. Departamento de Química orgánica
Date: 2011
Published in: Organic and Biomolecular Chemistry, 9, 3698-3713.
Document type: Article
Abstract: A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin and galactonojirimycin is reported. The synthetic strategy takes advantage of the ability of endocyclic pseudoamide-type atom...
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Cite: Aguilar Moncayo, M., García Moreno, M.I., Trapero, A., Egido Gabás, M., Llebaria, A., García Fernández, J.M. y Ortiz Mellet, C. (2011). Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase. Organic and Biomolecular Chemistry, 9, 3698-3713.
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URI: http://hdl.handle.net/11441/67289

DOI: 10.1039/C1OB05234A

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