Data

NameOrtiz Mellet, Carmen
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryCatedrática de Universidad
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  Statistics

  • Items

    58

  • Visits

    7001

  • Downloads

    7887

  Publications

 

PhD Thesis
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Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros

Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Carbajo Gordillo, Ana Isabel (2021-01-29)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ...
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Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy

Cano Cano, Fátima; Alcalde Estévez, Elena; Gómez Jaramillo, Laura; Iturregui, Marta; Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen; Campos Caro, Antonio; López Tinoco, Cristina (Frontiers, 2021-01-01)
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Cyclodextrin-Based Functional Glyconanomaterials

Rivero Barbarroja, Gonzalo; Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI, 2020-12-01)
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
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Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

Manzanares, Darío; Pérez Carrión, Mª Dolores; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (MDPI, 2020-01-01)
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ...
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Carbohydrate supramolecular chemistry: beyond the multivalent effect

González Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2020-01-01)
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ...
PhD Thesis
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Control de las propiedades supramoleculares de ciclodextrinas mediante la incorporación de “clips” aromáticos. Aplicación al transporte de material génico.

Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; Neva Rodríguez, Tania (2019-06-28)
Las ciclodextrinas son ciclooligosacáridos naturales formados por unidades de D-glucopiranosa unidas mediante enlaces ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Carbajo-Gordillo, Ana I.; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
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Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions

Neva, Tania; Carmona, Thais; Benito, Juan M.; Przybylski, Cédric; Ortiz Mellet, Carmen; Mendicuti, Francisco; García Fernández, José Manuel (Frontiers Media, 2019-01-01)
The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ...
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

Sánchez Fernández, Elena Matilde; García Moreno, M. Isabel; García Hernández, Raquel; Padrón, José M.; García Fernández, José Manuel; Gamarro, Francisco; Ortiz Mellet, Carmen (MDPI, 2019-01-01)
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ...
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Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019-01-01)
Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
PhD Thesis
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Glicobióticos: desarrollo de caramelos con propiedades funcionales

Ortiz Mellet, Carmen; García Fernández, José Manuel; Atencio Genes, Loyda Esther (2017-07-17)
La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ...
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Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease

García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017-01-01)
Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
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Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

Varan, Gamze; Ortiz Mellet, Carmen; Benito, Juan M.; Bilensoy, Erem (2017-01-01)
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its ...
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A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin

Mazzaglia, Antonio; Micali, Norberto; Villari, Valentina; Zagami, Roberto; Pennisi, R.M.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Sciortino, M.T.; Scolaro, L.M. (John Wiley & Sons, 2017-01-01)
The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ...
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Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells

Gallego-Yerga, Laura; Posadas, Inmaculada; Torre, Cristina de la; Ruiz-Almansa, Jesús; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel; Ceña, Valentín (Frontiers Media, 2017-01-01)
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ...
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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

García Moreno, M. Isabel; Ortega Caballero, Fernando; Rísquez Cuadro, Rocio; García Fernández, José Manuel; Ortiz Mellet, Carmen (2017-01-01)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ...
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Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells

Martínez-Negro, M.; Caracciolo, G.; Palchetti, S.; Pozzi, D.; Capriotti, A.L.; Cavaliere, C.; Laganà, A; Ortiz Mellet, Carmen; Benito, Juan M.; García Fernández, José Manuel; Aicart, Emilio (Elsevier, 2017-01-01)
The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ...
PhD Thesis
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Glicoterapias contra el cáncer, la leishmania y enfermedades de depósito lisosomal

Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen; Gonçalves Pereira, Rita Alexandra (2016-05-06)
Master's Final Project
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Iminoazúcares sp2 en inmunoterapias contra el cáncer

Ortiz Mellet, Carmen; Sánchez Fernández, Elena Matilde; Guillén Poza, Pablo Adrián (2016-01-01)
En la actualidad, los tratamientos más utilizados para combatir el cáncer se basan en el uso de quimioterapia, radioterapia ...
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Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry

Przybylsk, Cédric; Benito, Juan M.; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016-01-01)
For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ...
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Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts

Navo, C.D.; Corzana, F.; Sánchez Fernández, Elena Matilde; Busto, J.H.; Avenoza, A.; Namba, E.; Higaki, Katsumi; Ortiz Mellet, Carmen; García Fernández, José Manuel; Peregrina, J.M. (Royal Society of Chemistry, 2016-01-01)
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ...
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Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities

Pflueger, Iris; Charrat, Coralie; Ortiz Mellet, Carmen; García Fernández, José Manuel; Di Giorgio, Christophe; Benito, Juan M. (Royal Society of Chemistry, 2016-01-01)
Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...
PhD Thesis
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Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos

Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Rodríguez Lavado, Julio (2015-11-27)
En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ...
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Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study

García Fernández, José Manuel; Gallego Yerga, Laura; Lomazzi, Michela; Franceschi, Valentina; Sansone, Francesco; Ortiz Mellet, Carmen; Donofrio, Gaetano; Casnati, Alessandro (Royal Society of Chemistry, 2015-01-01)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ...
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Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

Mata, Mario de la; Cotán, David; Oropesa Ávila, Manuel; Garrido Maraver, Juan; Cordero Morales, Mario David; Ortiz Mellet, Carmen; Ybot González, Patricia; García Fernández, José Manuel (Nature Publishing Group, 2015-01-01)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ...
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Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors

Fuente, Alex de la; Mena Barragán, Teresa; Farrar-Tobar, Ronald A.; Verdaguer, Xavier; García Fernández, José Manuel; Ortiz Mellet, Carmen; Riera, Antoni (Royal Society of Chemistry, 2015-01-01)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...
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Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides

Siriwardena, A.; Khanal, M.; Barras, Alexandre; Bande, O.; Mena Barragán, Teresa; Ortiz Mellet, Carmen; García Fernández, José Manuel; Boukheroub, R.; Szunerits, S. (Royal Society of Chemistry, 2015-01-01)
We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ...
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Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease

Castilla, Javier; Rísquez Cuadro, Rocio; Higaki, Katsumi; Nanba, Eiji; Ohno, Kousaku; Diaz, Yolanda; Ortiz Mellet, Carmen; García Fernández, José Manuel; Castillón, Sergio (Elsevier, 2015-01-01)
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ...
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Antileishmanial activity of sp2-iminosugar derivatives

Sánchez Fernández, Elena Matilde; Gómez Pérez, Veronica; García Hernández, Raquel; García Fernández, José Manuel; Plata, Gabriela B.; Padrón, José M.; Ortiz Mellet, Carmen; Catanys, Santiago; Gamarro, Francisco (Royal Society of Chemistry, 2015-01-01)
A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ...
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Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery

Méndez Ardoy, Alejandro; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; García Fernández, José Manuel (Royal Society of Chemistry, 2015-01-01)
Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ...
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Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles

Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015-01-01)
The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
PhD Thesis
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Preparación de nanosistemas por autoensamblaje de ciclodextrinas y calixarenos. Aplicaciones al transporte y a la liberación controlada de genes y fármacos

García Fernández, José Manuel; Ortiz Mellet, Carmen; Gallego Yerga, Laura (2014-11-07)
En esta Tesis hemos diseñado entidades moleculares basadas en derivados de beta-ciclodextrina y calix[4]areno capaces de ...
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Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities

Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014-01-01)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
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Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers

Gallego Yerga, Laura; Lomazzi, Michela; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel (Royal Society of Chemistry, 2014-01-01)
Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a ...
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Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators

Rodríguez Lavado, Julio; Sestito, Stefania E.; Cighetti, Roberto; Aguilar Moncayo, Eva M.; Oblak, Alja; Lainšček, Duško; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Jerala, Roman; Calabrese, Valentina; Peri, Francesco (American Chemical Society, 2014-01-01)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ...
PhD Thesis
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Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1

García Fernández, José Manuel; Ortiz Mellet, Carmen; Mena Barragán, Teresa (2013-12-13)
Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ...
Article
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New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells

Allan, Ghada; Ouadid-Ahidouch, Halima; Sánchez Fernández, Elena Matilde; Risquez Cuadrado, Rocío; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ahidouch, Ahmed (Public Library of Science, 2013-01-01)
sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ...
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Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions

Martínez, Álvaro; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013-01-01)
Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ...
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Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies

Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013-01-01)
Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ...
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Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo

Aranda, Cristina; Urbiola, Koldo; Méndez Ardoy, Alejandro; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ilarduya, C.T. (Elsevier, 2013-01-01)
Aim Development and evaluation of a new targeted gene delivery system by first preforming self-assembled nanocomplexes ...
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Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase

Aguilar Moncayo, Matilde; García Moreno, M. Isabel; Trapero, Ana; Egido Gabás, Meritxell; Llebaria, Amadeu; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry (Great Britain), 2011-01-01)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
PhD Thesis
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Plataformas multifuncionales basadas en ciclodextrinas: diseño de antitoxinas del ántrax y vectores de genes

Benito Hernández, Juan Manuel; García Fernández, José Manuel; Ortiz Mellet, Carmen; Díaz Moscoso, Alejandro (2010-02-12)
El trabajo desarrollado en esta Tesis aprovecha precisamente la faceta como plataforma nanométrica de las CDs. En ella se ...
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(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Ortiz Mellet, Carmen; García Fernández, José Manuel (Beilstein-Institut, 2010-01-01)
Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ...
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Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)

García Moreno, M. Isabel; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI AG, 2008-01-01)
Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
PhD Thesis
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Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato

García Fernández, José Manuel; Ortiz Mellet, Carmen; Bootello Iglesias, Purificación (2007-03-23)
Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ...
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Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides

Louis, Farida F.; García Moreno, M. Isabel; Balbuena Oliva, Patricia; Ortiz Mellet, Carmen; García Fernández, José Manuel (2007-01-01)
The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...
PhD Thesis
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Receptores derivados de carbohidratos para estudios de interacciones suprmoleculares

Ortiz Mellet, Carmen; García Fernández, José Manuel; Rodríguez Lucena, David (2006-12-01)
PhD Thesis
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Síntesis de ciclodextrinas multivalentes y evaluación de sus propiedades como sistemas transportadores de fármacos

Ortiz Mellet, Carmen; García Fernández, José Manuel; Gómez García, Marta (2005-01-01)
PhD Thesis
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Síntesis de glicomiméticos con nitrógeno pseudoamídico en el anillo y estudio de su actividad como inhibidores de glicosidasas

García Fernández, José Manuel; Ortiz Mellet, Carmen; Díaz Pérez, Paula (2005-01-01)
Book
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Aspectos fisiológicos de la remolacha azucarera de siembra otoñal

Echevarría Ruiz de Vargas, Cristina; Morillo-Velarde Pérez-Barquero, Rodrigo; Echevarría Ruiz de Vargas, Cristina; Feria Bourrellier, Ana Belén; Jiménez Segovia, Eduardo Terencio; Gordo, Luis F.; Morillo-Velarde Pérez-Barquero, Rodrigo; Martínez, Juan José; García-Mauriño Ruiz-Berdejo, Sofía; Monreal Hermoso, José Antonio; Bermejo, José Luís; Caballero, Rocío; Carmona, Lourdes; Torre Casas, Ángel de la; Cires Segura, Alfonso de; Álvarez Morales, Rosario; León Morillo, María Aránzazu; Gozález, María Cruz; Cejudo Fernández, Francisco Javier; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Junta de Andalucía, Consejería de Agricultura y Pesca, 2005-01-01)
Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ...
PhD Thesis
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Nuevos métodos de síntesis y purificación de dianhídridos de fructosa

Ortiz Mellet, Carmen; García Fernández, María; Rubio Castillo, Enrique Miguel (2004-10-29)
En el presente trabajo se han diseñado nuevos procesos de dimerización de la D-fructosa con objeto de favorecer la formación ...
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Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors

Jiménez Blanco, José Luis; Rubio, Enrique M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (2004-01-01)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ...
PhD Thesis
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Diseño y síntesis de receptores derivados de carbohidratos: Ciclodextrinas multivalentes, podandos y ciclotrehalinas. Evaluación de su capacidad de complejación y reconocimiento por lectinas

Ortiz Mellet, Carmen; García Fernández, José Manuel; Benito Hernández, Juan Manuel (2001-10-26)
Las células presentan en su superficie oligosacáridos ramificados unidos de modo covalente a lípidos (glicolípidos) o ...
PhD Thesis
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Síntesis de pseudooligosacáridos con puentes de tipo carbamida y de glicomiméticos relacionados con las polihidroxiindolizidinas. Estudios de inhibición enzimática

Fuentes Mota, José; Ortiz Mellet, Carmen; García Fernández, José Manuel; ; Díaz Pérez, Víctor Manuel (1998-10-16)
Existen sustancias naturales que presentan una gran analogía estructural con los carbohidratos y actúan como inhibidores ...
PhD Thesis
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Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos

Fuentes Mota, José; Ortiz Mellet, Carmen; Jiménez Blanco, José Luis (1996-01-01)
El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ...
PhD Thesis
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Reacción de isotiocianatos derivados de carbohidratos con compuestos α-aminocarbonilicos. Síntesis de glucosilaminotiazoles

; Fuentes Mota, José; Pradera Adrián, María Ángeles; Ortiz Mellet, Carmen (1984-01-01)
Se ha estudiado la reacción entre diversos isotiocianatos derivados de carbohidratos y compuestos alfa-aminocarbonílicos ...