Author profile: Ortiz Mellet, Carmen
Institutional data
| Name | Ortiz Mellet, Carmen |
| Department | Química Orgánica |
| Knowledge area | Química Orgánica |
| Professional category | Catedrática de Universidad |
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No. publications
90
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No. visits
10319
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12127
| Publications |
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PhD Thesis
 Estrategias de glicosidación con sp2-iminoazúcares. Síntesis de miméticos de manooligosacáridos multivalentes y estudio de sus interacciones con lectinas de tipo-C mediante técnicas espectroscópicas, computacionales y biofísicas
(2022-12-02)
Los iminoazúcares, análogos de carbohidratos en los que se ha sustituido el oxígeno endocíclico por un átomo de nitrógeno, ... |
PhD Thesis
Nuevas estrategias para el estudio y tratamiento de enfermedades neurodegenerativas, la regulación del sistema inmune y el transporte de ácidos nucleicos basadas en carbohidratos
(2022-06-17)
En esta tesis se abordan diferentes aspectos de la química supramolecuar de los carbohidratos con el objetivo general de ... |
Article
 Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the ... |
Article
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022-01-01)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ... |
Article
Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
(Wiley, 2022-01-01)
A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ... |
Article
Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics
(American Chemical Society, 2022-01-01)
A simple and efficient method for the stereoselective synthesis of nojirimycin α-C-glycoside derivatives has been developed ... |
PhD Thesis
Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros
(2021-01-29)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ... |
Article
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(MDPI, 2021-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ... |
Article
Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy
(Frontiers, 2021-01-01)
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ... |
Article
Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a ... |
Article
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021-01-01)
Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ... |
Article
A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors
(Royal Society of Chemistry, 2021-01-01)
A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ... |
Article
Cyclodextrin-Based Functional Glyconanomaterials
(MDPI, 2020-12-01)
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ... |
Article
Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis
(MDPI, 2020-01-01)
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ... |
Article
Carbohydrate supramolecular chemistry: beyond the multivalent effect
(Royal Society of Chemistry, 2020-01-01)
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ... |
Article
Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
(Royal Society of Chemistry, 2020-01-01)
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ... |
Article
Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis
(American Chemical Society, 2020-01-01)
The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ... |
PhD Thesis
Control de las propiedades supramoleculares de ciclodextrinas mediante la incorporación de “clips” aromáticos. Aplicación al transporte de material génico.
(2019-06-28)
Las ciclodextrinas son ciclooligosacáridos naturales formados por unidades de D-glucopiranosa unidas mediante enlaces ... |
Article
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
(The Society, 2019-06-19)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ... |
Article
Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions
(Frontiers Media, 2019-01-01)
The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ... |
Article
Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators
(Royal Society of Chemistry, 2019-01-01)
Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ... |
Article
Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids
(MDPI, 2019-01-01)
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ... |
Article
Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips
(Taylor & Francis, 2019-01-01)
The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ... |
Article
Pharmacological Chaperones for the Treatment of α-Mannosidosis
(American Chemical Society, 2019-01-01)
α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ... |
Article
Novel Therapies for Orphan Diseases
(American Chemical Society, 2019-01-01)
"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ... |
Article
Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
(Molecular Diversity Preservation International, 2018-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ... |
PhD Thesis
Glicobióticos: desarrollo de caramelos con propiedades funcionales
(2017-07-17)
La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ... |
Patent
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales
(Oficina Española de Patentes y Marcas , 2017-01-20)
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende ... |
Article
The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study
(2017-01-01)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ... |
Article
Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
(2017-01-01)
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its ... |
Article
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
(Elsevier, 2017-01-01)
The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ... |
Article
A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin
(John Wiley & Sons, 2017-01-01)
The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ... |
Article
Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
(American Chemical Society, 2017-01-01)
Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ... |
Article
Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells
(Frontiers Media, 2017-01-01)
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ... |
Article
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
(Future Medicine Ltd., 2017-01-01)
Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ... |
Article
Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose
(American Chemical Society, 2017-01-01)
Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ... |
| PhD Thesis |
Article
Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry
(Royal Society of Chemistry, 2016-01-01)
For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ... |
Article
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
(Royal Society of Chemistry, 2016-01-01)
Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ... |
Article
Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
(Royal Society of Chemistry, 2016-01-01)
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ... |
Master's Final Project
Iminoazúcares sp2 en inmunoterapias contra el cáncer
(2016-01-01)
En la actualidad, los tratamientos más utilizados para combatir el cáncer se basan en el uso de quimioterapia, radioterapia ... |
Article
Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes
(Royal Society of Chemistry, 2016-01-01)
The synthesis of the first examples of multivalent C-glycosides based on C60-fullerene or β-cyclodextrin cores by way of ... |
Article
Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
(Royal Society of Chemistry, 2016-01-01)
Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ... |
Article
Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
(Royal Society of Chemistry, 2016-01-01)
The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ... |
Article
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
(Elsevier, 2016-01-01)
Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ... |
Article
Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry
(Elsevier, 2016-01-01)
Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ... |
PhD Thesis
Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos
(2015-11-27)
En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ... |
Article
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
(Nature Publishing Group, 2015-01-01)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ... |
Article
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015-01-01)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ... |
Article
Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides
(Royal Society of Chemistry, 2015-01-01)
We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ... |
Article
Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery
(Royal Society of Chemistry, 2015-01-01)
Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ... |
Article
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
(Royal Society of Chemistry, 2015-01-01)
The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ... |
Article
Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
(Elsevier, 2015-01-01)
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ... |
Article
Antileishmanial activity of sp2-iminosugar derivatives
(Royal Society of Chemistry, 2015-01-01)
A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ... |
Article
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015-01-01)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ... |
Article
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
(Royal Society of Chemistry, 2015-01-01)
Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ... |
PhD Thesis
 Preparación de nanosistemas por autoensamblaje de ciclodextrinas y calixarenos. Aplicaciones al transporte y a la liberación controlada de genes y fármacos
(2014-11-07)
En esta Tesis hemos diseñado entidades moleculares basadas en derivados de beta-ciclodextrina y calix[4]areno capaces de ... |
Article
Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
(American Chemical Society, 2014-01-01)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ... |
Article
Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers
(Royal Society of Chemistry, 2014-01-01)
Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a ... |
Article
Structural basis of pharmacological chaperoning for human β-galactosidase
(Elsevier, 2014-01-01)
GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ... |
Article
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
(Royal Society of Chemistry, 2014-01-01)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ... |
PhD Thesis
Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1
(2013-12-13)
Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ... |
Article
Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions
(Royal Society of Chemistry (Great Britain), 2013-01-01)
Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ... |
Article
Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies
(Royal Society of Chemistry (Great Britain), 2013-01-01)
Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ... |
Article
Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo
(Elsevier, 2013-01-01)
Aim Development and evaluation of a new targeted gene delivery system by first preforming self-assembled nanocomplexes ... |
Article
New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells
(Public Library of Science, 2013-01-01)
sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ... |
Article
Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
(Elsevier, 2013-01-01)
In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ... |
Article
A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis
(Cell Press, 2013-01-01)
Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ... |
Patent
Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas.
(Oficina Española de Patentes y Marcas , 2011-12-23)
Derivados sp2 imnoazúcar como inhibidores de las ?-glicosidasas.Derivados glicosilados de fórmula I, donde los significados ... |
Article
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
(Royal Society of Chemistry (Great Britain), 2011-01-01)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ... |
Article
Pharmacological chaperone therapy for Gaucher disease: A patent review
(Taylor & Francis, 2011-01-01)
Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ... |
Article
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011-01-01)
Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ... |
PhD Thesis
Plataformas multifuncionales basadas en ciclodextrinas: diseño de antitoxinas del ántrax y vectores de genes
(2010-02-12)
El trabajo desarrollado en esta Tesis aprovecha precisamente la faceta como plataforma nanométrica de las CDs. En ella se ... |
Article
(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties
(Beilstein-Institut, 2010-01-01)
Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ... |
Article
Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
(Elsevier, 2010-01-01)
It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ... |
Patent
Nuevos derivados de ciclodextrinas selectivamente fucionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos.
(Oficina Española de Patentes y Marcas , 2008-04-01)
Nuevos derivados de coclodextrinas selectivamnet funcionalizados en su cara secundaria, procedimiento de preparación y ... |
Article
Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
(MDPI AG, 2008-01-01)
Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ... |
PhD Thesis
Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato
(2007-03-23)
Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ... |
Article
Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides
(2007-01-01)
The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ... |
| PhD Thesis |
Book
Aspectos fisiológicos de la remolacha azucarera de siembra otoñal
(Junta de Andalucía, Consejería de Agricultura y Pesca, 2005-01-01)
Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ... |
| PhD Thesis |
| PhD Thesis |
PhD Thesis
Nuevos métodos de síntesis y purificación de dianhídridos de fructosa
(2004-10-29)
En el presente trabajo se han diseñado nuevos procesos de dimerización de la D-fructosa con objeto de favorecer la formación ... |
Article
Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors
(2004-01-01)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ... |
PhD Thesis
Diseño y síntesis de receptores derivados de carbohidratos: Ciclodextrinas multivalentes, podandos y ciclotrehalinas. Evaluación de su capacidad de complejación y reconocimiento por lectinas
(2001-10-26)
Las células presentan en su superficie oligosacáridos ramificados unidos de modo covalente a lípidos (glicolípidos) o ... |
PhD Thesis
Síntesis de pseudooligosacáridos con puentes de tipo carbamida y de glicomiméticos relacionados con las polihidroxiindolizidinas. Estudios de inhibición enzimática
(1998-10-16)
Existen sustancias naturales que presentan una gran analogía estructural con los carbohidratos y actúan como inhibidores ... |
PhD Thesis
Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos
(1996-01-01)
El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ... |
PhD Thesis
Reacción de isotiocianatos derivados de carbohidratos con compuestos α-aminocarbonilicos. Síntesis de glucosilaminotiazoles
(1984-01-01)
Se ha estudiado la reacción entre diversos isotiocianatos derivados de carbohidratos y compuestos alfa-aminocarbonílicos ... |
Article
sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
(Elsevier, 219)
Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ... |