NameOrtiz Mellet, Carmen
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryCatedrática de Universidad
E-mailRequest
           
  • No. publications

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Article
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Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity

Ortega Caballero, Fernando; Santana Armas, Maria L.; Tros de Ilarduya, Conchita; Di Giorgio, Christophe; Tripier, Raphael; Le Bris, Nathalie; Ollier, Cedric; Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Méndez Ardoy, Alejandro (Royal Society of Chemistry, 2024)
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...
PhD Thesis
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Ciclodextrinas y glicomiméticos sensibles a estímulos: aplicaciones al transporte de ácidos nucleicos y a la regulación de glicosidasas

Rivero Barbarroja, Gonzalo; García Fernández, José Manuel; Ortiz Mellet, Carmen (2024)
En las últimas décadas se ha experimentado un avance notable en el diseño y preparación sistemas capaces de participar en ...
Article
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties

Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)
The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
Article
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Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives

Rivero Barbarroja, Gonzalo; Fernández Clavero, C.; García Iriepa, C.; Marcelo, G.; Padilla Pérez, María del Carmen; Neva, T.; Benito, J. M.; Maisonneuve, S.; Ortiz Mellet, Carmen; Xie, J.; García Fernández, J. M.; Mendicuti, F. (American Chemical Society, 2023)
β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling ...
Article
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Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma

González Cuesta, Manuel; Lai, Alan Chuan Ying; Chi, Po Yu; Hsu, I. Ling; Liu, Nien Tzu; Wu, Ko Chien; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2023)
Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
PhD Thesis
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Estrategias de glicosidación con sp2-iminoazúcares. Síntesis de miméticos de manooligosacáridos multivalentes y estudio de sus interacciones con lectinas de tipo-C mediante técnicas espectroscópicas, computacionales y biofísicas

Herrera González, Irene; Ortiz Mellet, Carmen; García Fernández, José Manuel (2022)
Los iminoazúcares, análogos de carbohidratos en los que se ha sustituido el oxígeno endocíclico por un átomo de nitrógeno, ...
PhD Thesis
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Nuevas estrategias para el estudio y tratamiento de enfermedades neurodegenerativas, la regulación del sistema inmune y el transporte de ácidos nucleicos basadas en carbohidratos

González Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (2022)
En esta tesis se abordan diferentes aspectos de la química supramolecuar de los carbohidratos con el objetivo general de ...
Article
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
Article
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A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells

de la Torre, Cristina; Játiva, Pablo; Posadas, Inmaculada; Manzanares, Darío; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ...
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Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ

Gómez Jaramillo, Laura; Cano Cano, Fátima; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; García Fernández, José Manuel; Alcalá, Martín; Álvarez Gallego, Fabiola; Iturregui, Marta; González Montelongo, M. Carmen; Campos Caro, Antonio; Arroba, Ana I.; Aguilar Diosdado, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the ...
Article
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Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations

Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan Manuel; Jiménez Blanco, José Luis; Santana Armas, María Luisa; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2022)
A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
Article
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Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics

Herrera González, Irene; González Cuesta, Manuel; García Moreno, M. Isabel; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2022)
A simple and efficient method for the stereoselective synthesis of nojirimycin α-C-glycoside derivatives has been developed ...
PhD Thesis
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Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros

Carbajo Gordillo, Ana Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis (2021)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ...
Article
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Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties

Sánchez Fernández, Elena Matilde; García Hernández, Raquel; Gamarro, Francisco; Arroba, Ana I.; Aguilar Diosdado, Manuel; Padrón, José M.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a ...
Article
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Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy

Cano Cano, Fátima; Alcalde Estévez, Elena; Gómez Jaramillo, Laura; Iturregui, Marta; Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen; Campos Caro, Antonio; López Tinoco, Cristina (Frontiers, 2021)
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ...
Article
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Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery

Carbajo Gordillo, Ana Isabel; González Cuesta, Manuel; Jiménez Blanco, José Luis; Benito, Juan M.; Santana, María L.; Carmona, Thais; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2021)
Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...
Article
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors

Lumbroso, Alexandre; Berthonneau, Clément; Beaudet, Isabelle; Quintard, Jean Paul; Planchat, Aurélien; García Moreno, M. Isabel; Ortiz Mellet, Carmen; Le Grognec, Erwan (Royal Society of Chemistry, 2021)
A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...
Article
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Cyclodextrin-Based Functional Glyconanomaterials

Rivero Barbarroja, Gonzalo; Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI, 2020)
Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
Article
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Carbohydrate supramolecular chemistry: beyond the multivalent effect

González Cuesta, Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2020)
It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby ...
Article
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Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

Herrera González, Irene; Sánchez Fernández, Elena Matilde; Sau, Abhijit; Nativi, Cristina; Garciá Fernández, José M.; Galán, M. Carmen; Ortiz Mellet, Carmen (American Chemical Society, 2020)
The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ...
Article
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

Bermejo, Iris A; Navo, Claudio D.; Castro López, Jorge; Guerreiro, Ana; Jiménez Moreno, Ester; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; Corzana, Francisco (Royal Society of Chemistry, 2020)
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ...
Article
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Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

Manzanares, Darío; Pérez Carrión, Mª Dolores; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (MDPI, 2020)
Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ...
PhD Thesis
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Control de las propiedades supramoleculares de ciclodextrinas mediante la incorporación de “clips” aromáticos. Aplicación al transporte de material génico.

Neva Rodríguez, Tania; Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen (2019)
Las ciclodextrinas son ciclooligosacáridos naturales formados por unidades de D-glucopiranosa unidas mediante enlaces ...
Article
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Carbajo Gordillo, Ana Isabel; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019)
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
Patent. Invention
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Procedimiento de preparación de caramelos con elevado contenido en oligosacáridos prebióticos

García Fernández, José Manuel; Atencio Genes, Loyda Ester; Ortiz Mellet, Carmen; Jérôme, François; Oliveira Vigier, Karine De; Audemar, Maïte; Gálvez Peralta, Julio Juan (Oficina Española de Patentes y Marcas (OEPM), 2019)
Procedimiento de preparación de caramelos con elevado contenido en oligosacáridos prebióticos. La presente invención ...
Article
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Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions

Neva, Tania; Carmona, Thais; Benito, Juan M.; Przybylski, Cédric; Ortiz Mellet, Carmen; Mendicuti, Francisco; García Fernández, José Manuel (Frontiers Media, 2019)
The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ...
Article
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Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

González Cuesta, Manuel; Goyard, David; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Renaudet, Olivier; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2019)
Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide ...
Article
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Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips

Neva, Tania; Ortiz Mellet, Carmen; Fernández, José M. García; Benito, Juan M. (Taylor & Francis, 2019)
The judicious combination of shaping and recognition elements in cage-type architectures represents a powerful strategy ...
Article
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Novel Therapies for Orphan Diseases

García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)
"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ...
Article
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Pharmacological Chaperones for the Treatment of α-Mannosidosis

Rísquez Cuadro, Rocío; Matsumoto, Reimi; Ortega Caballero, Fernando; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)
α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ...
Article
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

Sánchez Fernández, Elena Matilde; García Moreno, M. Isabel; García Hernández, Raquel; Padrón, José M.; García Fernández, José Manuel; Gamarro, Francisco; Ortiz Mellet, Carmen (MDPI, 2019)
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ...
Article
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
PhD Thesis
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Glicobióticos: desarrollo de caramelos con propiedades funcionales

Atencio Genes, Loyda Esther; Ortiz Mellet, Carmen; García Fernández, José Manuel (2017)
La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ...
Patent. Invention
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Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales

García Fernández, José Manuel; Sánchez Alcázar, José Antonio; De La Mata Fernández, Mario; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2017)
Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende ...
Article
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A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin

Mazzaglia, Antonio; Micali, Norberto; Villari, Valentina; Zagami, Roberto; Pennisi, R.M.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Sciortino, M.T.; Scolaro, L.M. (John Wiley & Sons, 2017)
The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ...
Article
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Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection

Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)
Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
Article
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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

García Moreno, M. Isabel; Ortega Caballero, Fernando; Rísquez Cuadro, Rocio; García Fernández, José Manuel; Ortiz Mellet, Carmen (2017)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ...
Article
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Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells

Martínez-Negro, M.; Caracciolo, G.; Palchetti, S.; Pozzi, D.; Capriotti, A.L.; Cavaliere, C.; Laganà, A; Ortiz Mellet, Carmen; Benito, Juan M.; García Fernández, José Manuel; Aicart, Emilio (Elsevier, 2017)
The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ...
Article
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Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells

Gallego-Yerga, Laura; Posadas, Inmaculada; Torre, Cristina de la; Ruiz-Almansa, Jesús; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel; Ceña, Valentín (Frontiers Media, 2017)
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ...
Article
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Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

Varan, Gamze; Ortiz Mellet, Carmen; Benito, Juan M.; Bilensoy, Erem (2017)
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its ...
Article
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Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease

García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017)
Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
Article
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Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose

Audemar, Maité; Atencio Genes, Loyda Esther; Ortiz Mellet, Carmen; Jérôme, F.; García Fernández, José Manuel; Oliveira Vigier, Karine De (American Chemical Society, 2017)
Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ...
PhD Thesis
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Glicoterapias contra el cáncer, la leishmania y enfermedades de depósito lisosomal

Gonçalves Pereira, Rita Alexandra; Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen (2016)
Article
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Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry

Przybylsk, Cédric; Benito, Juan M.; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)
For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ...
Article
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Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry

Przybylski, Cédric; Benito, Juan Manuel; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2016)
Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ...
Article
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Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts

Navo, C.D.; Corzana, F.; Sánchez Fernández, Elena Matilde; Busto, J.H.; Avenoza, A.; Namba, E.; Higaki, Katsumi; Ortiz Mellet, Carmen; García Fernández, José Manuel; Peregrina, J.M. (Royal Society of Chemistry, 2016)
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ...
Article
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases

Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2016)
Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
Article
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Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes

Stauffert, Fabien; Bodlenner, Anne; Nguyet Trinh, Thi Minh; García Moreno, M. Isabel; Ortiz Mellet, Carmen; Nierengarten, Jean François; Compain, Philippe (Royal Society of Chemistry, 2016)
The synthesis of the first examples of multivalent C-glycosides based on C60-fullerene or β-cyclodextrin cores by way of ...
Article
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Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme

Fuente, Alex de la; Rísquez Cuadro, Rocio; Verdaguer, Xavier; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen; Riera, Antoni (Elsevier, 2016)
Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
Article
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Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities

Pflueger, Iris; Charrat, Coralie; Ortiz Mellet, Carmen; García Fernández, José Manuel; Di Giorgio, Christophe; Benito, Juan M. (Royal Society of Chemistry, 2016)
Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...
Article
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Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles

Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Blanco Fernández, L.; Carmona, Thais; Marcelo, G.; Martínez Negro, María; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)
The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ...
Master's Final Project
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Iminoazúcares sp2 en inmunoterapias contra el cáncer

Guillén Poza, Pablo Adrián; Ortiz Mellet, Carmen; Sánchez Fernández, Elena Matilde (2016)
En la actualidad, los tratamientos más utilizados para combatir el cáncer se basan en el uso de quimioterapia, radioterapia ...
PhD Thesis
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Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos

Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen (2015)
En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ...
Patent. Invention
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Utilización de derivados bicíclicos de 1-desoxigalactonojirimicina en la preparación de un medicamento para el tratamiento de enfermedades relacionadas con beta-enzimas galactosidasas lisosómicas mutantes humanas

García Fernández, José Manuel; Ortiz Mellet, Carmen; Elji, Nanba; Katsumi , Higaki; Yoshiyuki, Suzuki (Oficina Española de Patentes y Marcas (OEPM), 2015)
La presente invención se refiere a un uso de un compuesto de fórmula (I) o una de sus sales, donde R representa una cadena ...
Article
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Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles

Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015)
The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
Article
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Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease

Castilla, Javier; Rísquez Cuadro, Rocio; Higaki, Katsumi; Nanba, Eiji; Ohno, Kousaku; Diaz, Yolanda; Ortiz Mellet, Carmen; García Fernández, José Manuel; Castillón, Sergio (Elsevier, 2015)
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ...
Article
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Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery

Méndez Ardoy, Alejandro; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; García Fernández, José Manuel (Royal Society of Chemistry, 2015)
Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ...
Article
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Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study

García Fernández, José Manuel; Gallego Yerga, Laura; Lomazzi, Michela; Franceschi, Valentina; Sansone, Francesco; Ortiz Mellet, Carmen; Donofrio, Gaetano; Casnati, Alessandro (Royal Society of Chemistry, 2015)
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ...
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Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

Mata, Mario de la; Cotán, David; Oropesa Ávila, Manuel; Garrido Maraver, Juan; Cordero Morales, Mario David; Ortiz Mellet, Carmen; Ybot González, Patricia; García Fernández, José Manuel (Nature Publishing Group, 2015)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity ...
Article
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Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles

Khanal, Manakamana; Larsonneur, Fanny; Raks, Victoriia; Barras, Alexandre; Baumann, Jean-Sébastien; Martin, Fernando Ariel; Martin, Fernando Ariel; Boukherroub, Rabah; Ghigo, Jean Marc; Ortiz Mellet, Carmen; Zaitsev, Vladimir; Garcia Fernandez, Jose M.; Beloin, Christophe; Siriwardena, Aloysius; Szunerits, Sabine (Royal Society of Chemistry, 2015)
Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ...
Article
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Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides

Siriwardena, A.; Khanal, M.; Barras, Alexandre; Bande, O.; Mena Barragán, Teresa; Ortiz Mellet, Carmen; García Fernández, José Manuel; Boukheroub, R.; Szunerits, S. (Royal Society of Chemistry, 2015)
We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ...
Article
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Antileishmanial activity of sp2-iminosugar derivatives

Sánchez Fernández, Elena Matilde; Gómez Pérez, Veronica; García Hernández, Raquel; García Fernández, José Manuel; Plata, Gabriela B.; Padrón, José M.; Ortiz Mellet, Carmen; Catanys, Santiago; Gamarro, Francisco (Royal Society of Chemistry, 2015)
A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ...
Article
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Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors

Fuente, Alex de la; Mena Barragán, Teresa; Farrar-Tobar, Ronald A.; Verdaguer, Xavier; García Fernández, José Manuel; Ortiz Mellet, Carmen; Riera, Antoni (Royal Society of Chemistry, 2015)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic ...
PhD Thesis
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Preparación de nanosistemas por autoensamblaje de ciclodextrinas y calixarenos. Aplicaciones al transporte y a la liberación controlada de genes y fármacos

Gallego Yerga, Laura; García Fernández, José Manuel; Ortiz Mellet, Carmen (2014)
En esta Tesis hemos diseñado entidades moleculares basadas en derivados de beta-ciclodextrina y calix[4]areno capaces de ...
Patent. Invention
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Uso de un compuesto de fórmula (i) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de gaucher, composición farmacéutica, un compuesto de fórmula (ib) y procedimiento de obtención.

Alfonso Palacin, Pilar; Moya García, Aurelio; Pino Ángeles, Almudena; Sánchez Jiménez, Francisca; Pocovi Mieras, Miguel; Giraldo Castellano, Pilar; García Moreno, Mª Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel (Oficina Española de Patentes y Marcas (OEPM), 2014)
Uso de un compuesto de fórmula (I) para la fabricación de un medicamento destinado al tratamiento de la enfermedad de ...
Article
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Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers

Gallego Yerga, Laura; Lomazzi, Michela; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel (Royal Society of Chemistry, 2014)
Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a ...
Article
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Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators

Rodríguez Lavado, Julio; Sestito, Stefania E.; Cighetti, Roberto; Aguilar Moncayo, Eva M.; Oblak, Alja; Lainšček, Duško; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Jerala, Roman; Calabrese, Valentina; Peri, Francesco (American Chemical Society, 2014)
An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ...
Article
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Structural basis of pharmacological chaperoning for human β-galactosidase

Suzuki, Hironori; Ohto, Umeharu; Higaki, Katsumi; Mena Barragán, Teresa; Aguilar Moncayo, Matilde; Ortiz Mellet, Carmen; Nanba, Eiji; García Fernández, José Manuel; Suzuki, Yoshiyuki; Shimizu, Toshiyuki (Elsevier, 2014)
GM1 gangliosidosis and Morquio B disease are autosomal recessive diseases caused by the defect in the lysosomal β-galactosidase ...
Article
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Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities

Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014)
Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
PhD Thesis
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Síntesis de iminoazúcares sp2 y evaluación de su actividad como chaperonas farmacológicas para el tratamiento de las enfermedades de Gaucher, Fabry y gangliosidosis GM1

Mena Barragán, Teresa; García Fernández, José Manuel; Ortiz Mellet, Carmen (2013)
Las enfermedades de depósito lisosomal (Lysosomal Storage Disorders, LSDs), entre las que se encuentran la enfermedad de ...
Article
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A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis

Takai, Tomoko; Higaki, Katsumi; Aguilar Moncayo, Matilde; Mena Barragán, Teresa; Hirano, Yuki; Yura, Kei; García Moreno, M. Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel; Suzuki, Yoshiyuki (Cell Press, 2013)
Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
Article
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Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies

Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)
Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ...
Article
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Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions

Martínez, Álvaro; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)
Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ...
Article
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New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells

Allan, Ghada; Ouadid-Ahidouch, Halima; Sánchez Fernández, Elena Matilde; Risquez Cuadrado, Rocío; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ahidouch, Ahmed (Public Library of Science, 2013)
sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on ...
Article
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Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo

Aranda, Cristina; Urbiola, Koldo; Méndez Ardoy, Alejandro; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ilarduya, C.T. (Elsevier, 2013)
Aim Development and evaluation of a new targeted gene delivery system by first preforming self-assembled nanocomplexes ...
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Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens

Peinado, M.J.; Echávarri, A; Ruiz, R.; Suárez Pereira, E.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Rubio, L. A. (Elsevier, 2013)
In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ...
Patent. Invention
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Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas.

Garcia Fernandez, Jose M.; Risquez-Cuadro, Rocio; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2011)
Derivados sp2 imnoazúcar como inhibidores de las ?-glicosidasas.Derivados glicosilados de fórmula I, donde los significados ...
Article
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Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery

Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011)
Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
Patent. Invention
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Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares

Ortiz Mellet, Carmen; Méndez Ardoy, Alejandro; Gómez García, Marta; Sevillano Trapero, Natalia; Girón González, María Dolores; Salto González, Rafael; Santoyo González, Francisco; García Fernández, José Manuel (Oficina Española de Patentes y Marcas (OEPM), 2011)
Ciclooligosacáridos anfifílicos policatiónicos y su uso como transportadores moleculares. La presente invención se refiere ...
Patent. Invention
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Compuestos potenciadores de la actividad de glicosidasas mutantes

García Fernández, José Manuel; Ortiz Mellet, Carmen; García Moreno, María Isabel; Aguilar Moncayo, Matilde; Suzuki, Yoshiyuki; Ohno, Kousaku (Oficina Española de Patentes y Marcas (OEPM), 2011)
Compuestos potenciadores de la actividad de glicosida sas mutantes, con actividad inhibidoras de enzimas gli cosidasas y ...
Article
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Pharmacological chaperone therapy for Gaucher disease: A patent review

Benito, Juan Manuel; García Fernández, José Manuel; Ortiz Mellet, Carmen (Taylor & Francis, 2011)
Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ...
Article
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Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase

Aguilar Moncayo, Matilde; García Moreno, M. Isabel; Trapero, Ana; Egido Gabás, Meritxell; Llebaria, Amadeu; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry (Great Britain), 2011)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
Article
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Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues

Brumshtein, Boris; Aguilar Moncayo, Matilde; Benito, Juan Manuel; García Fernández, José Manuel; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H.; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2011)
Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...
PhD Thesis
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Plataformas multifuncionales basadas en ciclodextrinas: diseño de antitoxinas del ántrax y vectores de genes

Díaz Moscoso, Alejandro; Benito Hernández, Juan Manuel; García Fernández, José Manuel; Ortiz Mellet, Carmen (2010)
El trabajo desarrollado en esta Tesis aprovecha precisamente la faceta como plataforma nanométrica de las CDs. En ella se ...
Article
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(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Ortiz Mellet, Carmen; García Fernández, José Manuel (Beilstein-Institut, 2010)
Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ...
Article
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Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)

Díaz Moscoso, Alejandro; Vercauteren, Dries; Rejman, Joanna; Benito, Juan M.; Ortiz Mellet, Carmen; De Smedt, Stefaan C.; Fernández, José M. García (Elsevier, 2010)
It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ...
Patent. Invention
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Nuevos caramelos con elevado contenido en oligosacáridos prebióticos, procedimiento de preparación y utilización

Rubio Castillo, Enrique Miguel; Gómez García, Marta; Ortiz Mellet, Carmen; Garcia Fernandez, Jose Manuel; Zarzuelo Zurita, Antonio; Gálvez Peralta, Julio Juan; Duval, Raphael (Organización Mundial de la Propiedad Intelectual (OMPI), 2009)
La presente invención se refiere a la transformación de azúcares alimentarios que contienen D-fructosa, en caramelos ...
Patent. Invention
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Nuevos derivados de ciclodextrinas selectivamente fucionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos.

Balbuena Oliva, Patricia; Garcia Fernandez, Jose Manuel; Duval, Raphael; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2008)
Nuevos derivados de coclodextrinas selectivamnet funcionalizados en su cara secundaria, procedimiento de preparación y ...
Article
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Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)

García Moreno, M. Isabel; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI AG, 2008)
Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
PhD Thesis
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Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato

Bootello Iglesias, Purificación; García Fernández, José Manuel; Ortiz Mellet, Carmen (2007)
Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ...
Article
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Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides

Louis, Farida F.; García Moreno, M. Isabel; Balbuena Oliva, Patricia; Ortiz Mellet, Carmen; García Fernández, José Manuel (2007)
The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...
PhD Thesis
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Receptores derivados de carbohidratos para estudios de interacciones supramoleculares

Rodríguez Lucena, David; Ortiz Mellet, Carmen; García Fernández, José Manuel (2006)
PhD Thesis
Book
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Aspectos fisiológicos de la remolacha azucarera de siembra otoñal

Echevarría Ruiz de Vargas, Cristina; Feria Bourrellier, Ana Belén; Jiménez Segovia, Eduardo Terencio; Gordo, Luis F.; Morillo-Velarde Pérez-Barquero, Rodrigo; Martínez, Juan José; García-Mauriño Ruiz-Berdejo, Sofía; Monreal Hermoso, José Antonio; Bermejo, José Luís; Caballero, Rocío; Carmona, Lourdes; Torre Casas, Ángel de la; Cires Segura, Alfonso de; Álvarez Morales, Rosario; León Morillo, María Aránzazu; Gozález, María Cruz; Cejudo Fernández, Francisco Javier; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Echevarría Ruiz de Vargas, Cristina; Morillo-Velarde Pérez-Barquero, Rodrigo (Junta de Andalucía, Consejería de Agricultura y Pesca, 2005)
Conceptos generales del metabolismo; crecimiento y desarrollo; actividades enzimáticas; niveles de adenilatos; efecto del ...
PhD Thesis
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Síntesis de ciclodextrinas multivalentes y evaluación de sus propiedades como sistemas transportadores de fármacos

Gómez García, Marta; Ortiz Mellet, Carmen; García Fernández, José Manuel (2005)
PhD Thesis
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Nuevos métodos de síntesis y purificación de dianhídridos de fructosa

Rubio Castillo, Enrique Miguel; Ortiz Mellet, Carmen; García Fernández, María (2004)
En el presente trabajo se han diseñado nuevos procesos de dimerización de la D-fructosa con objeto de favorecer la formación ...
Article
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Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors

Jiménez Blanco, José Luis; Rubio, Enrique M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (2004)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ...
PhD Thesis
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Diseño y síntesis de receptores derivados de carbohidratos: Ciclodextrinas multivalentes, podandos y ciclotrehalinas. Evaluación de su capacidad de complejación y reconocimiento por lectinas

Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (2001)
Las células presentan en su superficie oligosacáridos ramificados unidos de modo covalente a lípidos (glicolípidos) o ...
PhD Thesis
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Síntesis de pseudooligosacáridos con puentes de tipo carbamida y de glicomiméticos relacionados con las polihidroxiindolizidinas. Estudios de inhibición enzimática

Díaz Pérez, Víctor Manuel; Fuentes Mota, José; Ortiz Mellet, Carmen; García Fernández, José Manuel;  (1998)
Existen sustancias naturales que presentan una gran analogía estructural con los carbohidratos y actúan como inhibidores ...
PhD Thesis
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Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos

Jiménez Blanco, José Luis; Fuentes Mota, José; Ortiz Mellet, Carmen (1996)
El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ...
PhD Thesis
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Reacción de isotiocianatos derivados de carbohidratos con compuestos α-aminocarbonilicos. Síntesis de glucosilaminotiazoles

Ortiz Mellet, Carmen; ; Fuentes Mota, José; Pradera Adrián, María Ángeles (1984)
Se ha estudiado la reacción entre diversos isotiocianatos derivados de carbohidratos y compuestos alfa-aminocarbonílicos ...
Article
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sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo

Schaeffer, Evelyne; Sánchez Fernández, Elena Matilde; Gonçalves-Pereira, Rita; Flacher, Vincent; Lamon, Delphine; Duval, Monique; Fauny, Jean Daniel; García Fernández, José Manuel; Mueller, Christopher G.; Ortiz Mellet, Carmen (Elsevier, 219)
Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ...