Artículo
Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
Autor/es | Gómez Jaramillo, Laura
Cano Cano, Fátima Sánchez Fernández, Elena Matilde ![]() ![]() ![]() ![]() ![]() ![]() Ortiz Mellet, Carmen ![]() ![]() ![]() ![]() ![]() ![]() ![]() García Fernández, José Manuel Alcalá, Martín Álvarez Gallego, Fabiola Iturregui, Marta González Montelongo, M. Carmen Campos Caro, Antonio Arroba, Ana I. Aguilar Diosdado, Manuel |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-09-02 |
Publicado en |
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Resumen | Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJ is able to abolish inflammation ... Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJ is able to abolish inflammation via the induction of autophagy flux and provokes the inhibition of inflammasome complex in ex vivo and in vitro models, using adult kidney explants from BB rats. The contribution of (Ss)-DS-ONJ to reducing inflammatory events is mediated by the inhibition of classical stress kinase pathways and the blocking of inflammasome complex activation. The (Ss)-DS-ONJ treatment is able to inhibit the epithelial-to-mesenchymal transition (EMT) progression, but only when the IL18 levels are reduced by the treatment. These findings suggest that (Ss)-DS-ONJ could be a novel, and multifactorial treatment for DN. |
Agencias financiadoras | Junta de Andalucía Ministerio de Ciencia, Innovación y Universidades (MICINN). España |
Identificador del proyecto | PI-0012-2019
![]() PI20-01330 ![]() PI-0036-2020 ![]() P20_00166 ![]() RTI2018- 097609-B-C21 ![]() PID2021-124247OB-C21 ![]() |
Cita | Gómez Jaramillo, L., Cano Cano, F., Sánchez Fernández, E.M., Ortiz Mellet, C., García Fernández, J.M., Alcalá, M.,...,Aguilar Diosdado, M. (2022). Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ. International Journal of Molecular Sciences, 23 (15), 8450. |
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Unravelling the Inflammatory.pdf | 4.448Mb | ![]() | Ver/ | |