Artículo
Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
Autor/es | Carbajo Gordillo, Ana Isabel
González Cuesta, Manuel Jiménez Blanco, José Luis Benito, Juan M. Santana, María L. Carmona, Thais Ortiz Mellet, Carmen García Fernández, José Manuel |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-04-19 |
Publicado en |
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Resumen | Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic scaffold allows engineering patchy molecular nanoparticles leveraging directional interactions ... Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic scaffold allows engineering patchy molecular nanoparticles leveraging directional interactions that emulate those controlling self-assembling processes in viral capsids. The resulting trilobular amphiphilic derivatives, featuring a Mickey Mouse architecture, can electrostatically interact with plasmid DNA (pDNA) and further engage in hydrophobic contacts to promote condensation into transfectious nanocomplexes. Notably, the topology and internal structure of the cyclooligosaccharide/pDNA co-assemblies can be molded by fine-tuning the valency and characteristics of the cationic and lipophilic patches, which strongly impacts the transfection efficacy in vitro and in vivo. Outstanding organ selectivities can then be programmed with no need of incorporating a biorecognizable motif in the formulation. The results provide a versatile strategy for the construction of fully synthetic and perfectly monodisperse nonviral gene delivery systems uniquely suited for optimization schemes by making cyclooligosaccharide patchiness the focus. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Agencia Estatal de Investigación. España Universidad de Alcalá de Henares European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | RTI2018-097609-B-C21
RTI2018-097609-B-C22 PID2019-105858RB-I00 CCG19/CC-033 |
Cita | Carbajo-Gordillo, A.I., González Cuesta, M., Jiménez Blanco, J.L., Benito, J.M., Santana, M.L., Carmona, T.,...,García Fernández, J.M. (2021). Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery. Chemistry - A European Journal, 27 (36), 9429-9438. |
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Chemistry A European J - 2021 - ... | 2.372Mb | [PDF] | Ver/ | |