idUS - Author profile: Jiménez Blanco, José Luis

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Name	Jiménez Blanco, José Luis
Department	Química Orgánica
Knowledge area	Química Orgánica
Professional category	Profesor Titular de Universidad
E-mail	Request

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18
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Publications
Article Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan M.; Jiménez Blanco, José Luis; Santana Armas, María L.; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José M. (Wiley, 2022-01-01) A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
PhD Thesis Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Carbajo Gordillo, Ana Isabel (2021-01-29) La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico ...
Article Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery Carbajo Gordillo, Ana Isabel; González Cuesta, Manuel; Jiménez Blanco, José Luis; Benito, Juan M.; Santana, María L.; Carmona, Thais; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2021-01-01) Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...
Article Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis Manzanares, Darío; Pérez Carrión, Mª Dolores; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (MDPI, 2020-01-01) Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ...
Article Nanoparticle-delivered HIV peptides to dendritic cells a promising approach to generate a therapeutic vaccine Martín Moreno, Alba; Jiménez Blanco, José Luis; Mosher, Jamie; Swanson, Douglas R.; García Fernández, José Manuel; Sharma, Ajit; Ceña, Valentín; Muñoz Fernández, María Angeles (Multidisciplinary Digital Publishing Institute (MDPI), 2020-01-01) Finding a functional cure for HIV-1 infection will markedly decrease the social and economic burden of this disease. In ...
Article Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties Carbajo Gordillo, Ana Isabel; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19) An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
PhD Thesis Evaluación de la eficiencia de diversos alcoholes alifáticos empleados durante la molienda del cemento portland. Alejandre Sánchez, Francisco Javier; Jiménez Blanco, José Luis; García Soria, María del Valle (2017-09-29) El cemento es uno de los materiales de construcción más empleados en el mundo. Es un conglomerante hidráulico con excelentes ...
Article Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017-01-01) Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
Article Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules Massaro, M.; Riela, S.; Baiamonte, C.; Jiménez Blanco, José Luis; Giordano, C.; Lo Meo, P; Milioto, S.; Noto, R. (Royal Society of Chemistry, 2016-01-01) A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized ...
Article Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Blanco Fernández, L.; Carmona, Thais; Marcelo, G.; Martínez Negro, María; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016-01-01) The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ...
PhD Thesis Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Rodríguez Lavado, Julio (2015-11-27) En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ...
Article Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015-01-01) The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
Article Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators Rodríguez Lavado, Julio; Sestito, Stefania E.; Cighetti, Roberto; Aguilar Moncayo, Eva M.; Oblak, Alja; Lainšček, Duško; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Jerala, Roman; Calabrese, Valentina; Peri, Francesco (American Chemical Society, 2014-01-01) An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ...
Article Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014-01-01) Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
Article Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013-01-01) Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ...
Article (Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Ortiz Mellet, Carmen; García Fernández, José Manuel (Beilstein-Institut, 2010-01-01) Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. ...
Article Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors Jiménez Blanco, José Luis; Rubio, Enrique M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (2004-01-01) Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ...
PhD Thesis Tiocarbamatos y tioureas de carbohidratos: síntesis de 1,3-O,N-heterociclos enantiopuros, receptores quirales y glicomiméticos Fuentes Mota, José; Ortiz Mellet, Carmen; Jiménez Blanco, José Luis (1996-01-01) El medio biológico es esencialmente quiral. No sólo las biomeléculas, sino también muchos fármacos tienen componentes ...