Artículo
Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
Autor/es | Carbajo Gordillo, Ana Isabel
Rodríguez Lavado, Julio Jiménez Blanco, José Luis ![]() ![]() ![]() ![]() ![]() ![]() ![]() Benito Hernández, Juan Manuel Di Giorgio, Christophe Vélaz, Itziar Tros de Ilarduya, Concepción Ortiz Mellet, Carmen ![]() ![]() ![]() ![]() ![]() ![]() ![]() García Fernández, José Manuel |
Departamento | Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2019-06-19 |
Fecha de depósito | 2019-09-17 |
Publicado en |
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Resumen | An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ... An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo. |
Identificador del proyecto | SAF2016-76083-R
![]() CTQ2015-64425-C2-1-R ![]() CTQ2015-64425-C2-2-R ![]() RTI2018-097609-B-C21 ![]() RTI2018-097609-B-C22 ![]() FQM2012-1467 ![]() |
Cita | Carbajo-Gordillo, A.I., Rodríguez Lavado, J., Jiménez Blanco, J.L., Benito Hernández, J.M., Di Giorgio, C., Vélaz, I.,...,García Fernández, J.M. (2019). Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties. Chemical Communications, 55 (57), 8227-8230. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Trehalose based siamese twin.pdf | 3.647Mb | ![]() | Ver/ | |