idUS - Perfil del autor: García Moreno, M. Isabel

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Nombre	García Moreno, M. Isabel
Departamento	Química Orgánica
Área de conocimiento	Química Orgánica
Categoría profesional	Profesora Titular de Universidad
Correo electrónico	Solicitar

Nº publicaciones

15
Nº visitas

1357
Nº descargas

1627

Tipología

Orden

Publicaciones
Artículo sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022) The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
Artículo Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics Herrera González, Irene; González Cuesta, Manuel; García Moreno, M. Isabel; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2022) A simple and efficient method for the stereoselective synthesis of nojirimycin α-C-glycoside derivatives has been developed ...
Artículo Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021) A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
Artículo A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors Lumbroso, Alexandre; Berthonneau, Clément; Beaudet, Isabelle; Quintard, Jean Paul; Planchat, Aurélien; García Moreno, M. Isabel; Ortiz Mellet, Carmen; Le Grognec, Erwan (Royal Society of Chemistry, 2021) A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...
Artículo Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids Sánchez Fernández, Elena Matilde; García Moreno, M. Isabel; García Hernández, Raquel; Padrón, José M.; García Fernández, José Manuel; Gamarro, Francisco; Ortiz Mellet, Carmen (MDPI, 2019) The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ...
Artículo Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018) A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
Artículo The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study García Moreno, M. Isabel; Ortega Caballero, Fernando; Rísquez Cuadro, Rocio; García Fernández, José Manuel; Ortiz Mellet, Carmen (2017) The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ...
Artículo Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017) The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
Artículo Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017) Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
Artículo Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017) The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
Artículo Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes Stauffert, Fabien; Bodlenner, Anne; Nguyet Trinh, Thi Minh; García Moreno, M. Isabel; Ortiz Mellet, Carmen; Nierengarten, Jean François; Compain, Philippe (Royal Society of Chemistry, 2016) The synthesis of the first examples of multivalent C-glycosides based on C60-fullerene or β-cyclodextrin cores by way of ...
Artículo A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis Takai, Tomoko; Higaki, Katsumi; Aguilar Moncayo, Matilde; Mena Barragán, Teresa; Hirano, Yuki; Yura, Kei; García Moreno, M. Isabel; Ortiz Mellet, Carmen; García Fernández, José Manuel; Suzuki, Yoshiyuki (Cell Press, 2013) Lysosomal β-galactosidase (β-Gal) deficiency causes a group of disorders that include neuronopathic GM1 gangliosidosis and ...
Artículo Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase Aguilar Moncayo, Matilde; García Moreno, M. Isabel; Trapero, Ana; Egido Gabás, Meritxell; Llebaria, Amadeu; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry (Great Britain), 2011) A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
Artículo Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs) García Moreno, M. Isabel; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI AG, 2008) Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
Artículo Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides Louis, Farida F.; García Moreno, M. Isabel; Balbuena Oliva, Patricia; Ortiz Mellet, Carmen; García Fernández, José Manuel (2007) The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...