Data

NameGarcía Moreno, M. Isabel
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryProfesora Titular de Universidad
E-mailRequest
         

  Statistics

  • Items

    8

  • Visits

    742

  • Downloads

    801

  Publications

 

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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieters, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (MDPI, 2021-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

Sánchez Fernández, Elena Matilde; García Moreno, M. Isabel; García Hernández, Raquel; Padrón, José M.; García Fernández, José Manuel; Gamarro, Francisco; Ortiz Mellet, Carmen (MDPI, 2019-01-01)
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018-01-01)
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease

García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017-01-01)
Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

García Moreno, M. Isabel; Ortega Caballero, Fernando; Rísquez Cuadro, Rocio; García Fernández, José Manuel; Ortiz Mellet, Carmen (2017-01-01)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ...
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Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase

Aguilar Moncayo, Matilde; García Moreno, M. Isabel; Trapero, Ana; Egido Gabás, Meritxell; Llebaria, Amadeu; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry (Great Britain), 2011-01-01)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin ...
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Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)

García Moreno, M. Isabel; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI AG, 2008-01-01)
Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon ...
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Spacer-mediated synthesis of bis-spiroketal disaccharides: Nonsymmetrical furanose-pyranose difructose dianhydrides

Louis, Farida F.; García Moreno, M. Isabel; Balbuena Oliva, Patricia; Ortiz Mellet, Carmen; García Fernández, José Manuel (2007-01-01)
The stereochemical outcome of the dimerization reaction of D-fructose, leading to tricyclic bis-spiroketal systems, can ...