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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

 

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Opened Access TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
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Author: Gómez Herreros, Fernando
Zagnoli Vieira, Guido
Ntai, Ioanna
Martínez Macías, María Isabel
Anderson, Rhona M.
Herrero Ruíz, Andrés
Caldecott, Keith W.
Department: Universidad de Sevilla. Departamento de Genética
Date: 2017
Published in: Nature Communications, 8 (233), 1-8.
Document type: Article
Abstract: DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiestera...
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Cite: Gómez Herreros, F., Zagnoli Vieira, G., Ntai, I., Martínez Macías, M.I., Anderson, R.M., Herrero Ruíz, A. y Caldecott, .W. (2017). TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nature Communications, 8 (233), 1-8.
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URI: http://hdl.handle.net/11441/63912

DOI: 10.1038/s41467-017-00307-y

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