Perfil del autor: Gómez Herreros, Fernando
Datos institucionales
Nombre | Gómez Herreros, Fernando |
Departamento | Genética |
Área de conocimiento | Genética |
Categoría profesional | Profesor Contratado Doctor |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
15
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Nº visitas
1666
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Nº descargas
1623
Publicaciones |
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Artículo
TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023)
DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 ... |
Artículo
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
(Cell Press, 2023)
To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To ... |
Tesis Doctoral
Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
(2023)
Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de doble ... |
Artículo
Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
(Oxford University Press, 2020)
DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome ... |
Artículo
FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress
(Rockefeller University Press, 2019)
FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are ... |
Artículo
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
(Frontiers Media, 2019)
DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death ... |
Artículo
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)
DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome ... |
Artículo
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
(Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA ... |
Artículo
Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections
(American Society for Microbiology, 2015)
Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, ... |
Artículo
Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology Inc., 2013)
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Artículo
TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
(Public Library of Science, 2013)
Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ... |
Artículo
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
(Oxford University Press, 2012)
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume ... |
Artículo
One step back before moving forward: regulation of transcription elongation by arrest and backtracking
(Wiley-Blackwell, 2012)
RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. ... |
Artículo
Yeast Genetic Analysis Reveals the Involvement of Chromatin Reassembly Factors in Repressing HIV-1 Basal Transcription
(Public Library of Science, 2009)
Rebound of HIV viremia after interruption of anti-retroviral therapy is due to the small population of CD4+ T cells that ... |
Artículo
A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region
(2006)
The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in ... |