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Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?

Opened Access Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?
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Autor: Miguel Rodríguez, Manuel de
Fernández-Santos, José María
Utrilla, José Carmelo
Carrillo Vico, Antonio
Borrero, J.
Conde Amiano, Esperanza
Guerrero Montavez, Juan Miguel
Martín-Lacave, Inés
Departamento: Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica
Universidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunología
Universidad de Sevilla. Departamento de Biología Celular
Fecha: 2005-07-01
Publicado en: Histology and Histopathology, 20 (3), 713-718.
Tipo de documento: Artículo
Resumen: Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the p...
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Cita: Miguel Rodríguez, M.d., Fernández-Santos, J.M., Utrilla, J.C., Carrillo Vico, A., Borrero, J., Conde Amiano, E.,...,Martín-Lacave, I. (2005). Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?. Histology and Histopathology, 20 (3), 713-718.
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URI: http://hdl.handle.net/11441/59852

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