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dc.creatorMiguel Rodríguez, Manuel dees
dc.creatorFernández-Santos, José Maríaes
dc.creatorUtrilla Alcolea, José Carmeloes
dc.creatorCarrillo Vico, Antonioes
dc.creatorBorrero, J.es
dc.creatorConde Amiano, Esperanzaes
dc.creatorGuerrero Montávez, Juan Migueles
dc.creatorMartín Lacave, Inés Maríaes
dc.date.accessioned2017-05-16T07:52:51Z
dc.date.available2017-05-16T07:52:51Z
dc.date.issued2005-07-01
dc.identifier.citationMiguel Rodríguez, M.d., Fernández-Santos, J.M., Utrilla, J.C., Carrillo Vico, A., Borrero, J., Conde Amiano, E.,..., Martín Lacave, I.M.(2005). Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?. Histology and Histopathology, 20 (3), 713-718.
dc.identifier.issn02133911es
dc.identifier.urihttp://hdl.handle.net/11441/59852
dc.description.abstractThyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the possibility that C-cells present TRH-Rs for the autocrine control of its own TRH production. Our results showed consistent expression for both receptors, TRH-R1 and TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC C13 follicular cells. Our data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relation.ispartofHistology and Histopathology, 20 (3), 713-718.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRat thyroides
dc.subjectFollicular cellses
dc.titleThyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?es
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Citología e Histología Normal y Patológicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
idus.format.extent6es
dc.journaltitleHistology and Histopathologyes
dc.publication.volumen20es
dc.publication.issue3es
dc.publication.initialPage713es
dc.publication.endPage718es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional