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Spanish Multicenter Study of the Epidemiology and Mechanisms of Amoxicillin-Clavulanate Resistance in Escherichia coli

Opened Access Spanish Multicenter Study of the Epidemiology and Mechanisms of Amoxicillin-Clavulanate Resistance in Escherichia coli

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Autor: Ortega, Adriana
Oteo, Jesús
Aranzamendi-Zaldumbide, Maitane
Bartolomé, Rosa M.
Bou, Germán
Cercenado, Emilia
Conejo Gonzalo, Mª Carmen
González-López, Juan José
Marín, Mercedes
Martínez-Martínez, Luis
Marino, María
Ferran, Navarro
Oliver, Antonio
Pascual Hernández, Álvaro
Rivera, Alba
Rodríguez-Baño, Jesús
Weber, Irene
Aracil, Belén
Campos, José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Universidad de Sevilla. Departamento de Medicina
Fecha: 2012-07
Publicado en: Antimicrobial Agents and Chemotherapy, 56(7), 3576-3581
Tipo de documento: Artículo
Resumen: We conducted a prospective multicenter study in Spain to characterize the mechanisms of resistance to amoxicillin-clavu-lanate (AMC) in Escherichia coli. Up to 44 AMC-resistant E. coli isolates (MIC>32/16 g/ml) were collected at each of theseven participant hospitals. Resistance mechanisms were characterized by PCR and sequencing. Molecular epidemiology was studied by pulsed-field gel electrophoresis (PFGE) and by multilocus sequence typing. Overall AMC resistance was 9.3%. The resistance mechanisms detected in the 257 AMC-resistant isolates were OXA-1 production (26.1%), hyperpro-duction of penicillinase (22.6%), production of plasmidic AmpC (19.5%), hyperproduction of chromosomic AmpC(18.3%), and production of inhibitor-resistant TEM (IRT) (17.5%). The IRTs identified were TEM-40 (33.3%), TEM-30(28.9%), TEM-33 (11.1%), TEM-32 (4.4%), TEM-34 (4.4%), TEM-35 (2.2%), TEM-54 (2.2%), TEM-76 (2.2%), TEM-79(2.2%), and the new TEM-185 (8.8%). By PFGE, a high degree of genetic diversity was o...
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Tamaño: 482.0Kb
Formato: PDF

URI: http://hdl.handle.net/11441/40585

DOI: http://dx.doi.org/10.1128/AAC.06393-11

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