Author profile: Pascual Hernández, Álvaro
Institutional data
| Name | Pascual Hernández, Álvaro |
| Department | Microbiología |
| Knowledge area | Microbiología |
| Professional category | Catedrático de Universidad (V) |
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No. publications
112
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| Publications |
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PhD Thesis
 Strategies to potentiate bactericidal antimicrobial activity based on the suppression of bacterial stress response systems
(2023-05-25)
One of the major threats to human health is the emergence of antimicrobial resistance. Since the discovery of antimicrobials, ... |
PhD Thesis
 Actividad de biocidas frente a aislados de Klebsiella pneumoniae productor de carbapenemasa
(2022-10-27)
La diseminación de clones epidémicos de Klebsiella pneumoniae productor de carbapenemasa (Kp-PC) es un problema de salud ... |
PhD Thesis
Heterorresistencia a fosfomicina en Escherichia coli: bases moleculares y efecto en su potencial terapéutico
(2022-03-15)
En las últimas décadas, el aumento progresivo de la resistencia a los antimicrobianos se ha convertido en un problema ... |
Article
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial
(Jama Nerwork Open, 2022-01-01)
Importance The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant ... |
Article
Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents
(American Society for Microbiology, 2022-01-01)
Escherichia coli ST131 clade C is an important driver for fluoroquinolone resistance (FQ-R). We conducted a prospective ... |
Article
The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection
(Nature Publishing Group, 2022-01-01)
Since their discovery, toxin-antitoxin (TA) systems have captivated the attention of many scientists. Recent studies have ... |
Article
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ... |
Article
Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19
(Nature Publishing Group, 2022-01-01)
The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we ... |
Article
Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software
(Frontiers Media S.A., 2022-01-01)
In this study, we evaluate the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry ... |
Article
CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3
(Frontiers Media S.A., 2022-01-01)
Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the ... |
Article
Phenotypic and Genomic Comparison of Klebsiella pneumoniae Lytic Phages: vB_KpnM-VAC66 and vB_KpnM-VAC13
(MDPI, 2021-12-31)
Klebsiella pneumoniae is a human pathogen that worsens the prognosis of many immuno compromised patients. Here, we annotated ... |
Article
In vitro activity of cefiderocol and comparators against isolates of Gram-negative bacterial pathogens from a range of infection sources: SIDERO‑WT‑2014−2018 studies in Spain
(Science Direct, 2021-07-15)
Objectives: The incidence of antimicrobial resistance in Europe is rising. Cefiderocol is approved in Eu- rope for treatment ... |
Article
Synergistic Quinolone Sensitization by Targeting the recA SOS Response Gene and Oxidative Stress
(American Society for Microbiology, 2021-03-18)
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, ... |
Article
CON: carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant enterobacterales
(2021-02-24)
Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone resistant ... |
Article
Reporting antimicrobial susceptibilities and resistance phenotypes in Staphylococcus spp.: a nationwide proficiency study
(Oxford University Press, 2021-02-08)
Objectives To evaluate the proficiency of microbiology laboratories in Spain in antimicrobial susceptibility testing (AST) ... |
Article
Propensity score and desirability of outcome ranking analysis of ertapenem for treatment of nonsevere bacteremic urinary tract infections due to extended-spectrum-beta-lactamase-producing enterobacterales in kidney transplant recipients
(American Society Microbiology, 2021-01-01)
There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase ... |
Article
Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnMVAC13 against clinical isolates of klebsiella pneumoniae
(American Society Microbiology, 2021-01-01)
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different strategies (resistance and ... |
Article
Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients
(Willey-Blackwell, 2021-01-01)
Background Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for ... |
Article
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
(Frontiers Media, 2021-01-01)
Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment ... |
Article
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
(American Society for Microbiology, 2021-01-01)
The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ... |
Article
Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients
(Elsevier, 2021-01-01)
Objectives: This study aimed to determine rates and risk factors of extended-spectrum b-lactamaseproducing Enterobacteriaceae ... |
Article
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
(Frontiers Media, 2021-01-01)
Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ... |
Article
Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
(Elsevier, 2021-01-01)
Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ... |
Article
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ): protocol for a randomised, pragmatic trial
(BMJ Publishing Group, 2021-01-01)
Introduction: Alternatives to carbapenems are needed in the treatment of third-generation cephalosporin-resistant ... |
PhD Thesis
Caracterización epidemiológica y clínica de la infección y colonización por Escherichia coli perteneciente al complejo clonal O25b/ST131
(2020-10-20)
Introducción. Escherichia coli secuenciotipo 131 (ST131) es un clon que combina capacidad de propagación exitosa, resistencia ... |
Article
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
(MDPI, 2020-09-02)
Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a ... |
Article
In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
(Nature Research, 2020-04-28)
The emergence of multidrug resistant (MDR) pathogenic bacteria is jeopardizing the value of antimicrobials, which had ... |
Article
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
(Multidisciplinary Digital Publishing Institute (MDPI), 2020-01-01)
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ... |
Article
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
(Oxford, 2020-01-01)
BACKGROUND: Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli ... |
Article
Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae
(2020-01-01)
Klebsiella pneumoniae is the clinically most important species within the genus Klebsiella and, as a result of the continuous ... |
| PhD Thesis |
Article
Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence
(Biomed Central, 2018-11-15)
Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the ... |
PhD Thesis
Bases moleculares de la resistencia a fosfomicina e implicación de las subpoblaciones con sensibilidad disminuida en su actividad in vitro.
(2018-01-18)
El interés global que existe actualmente, en recuperar antibióticos antiguos para el tratamiento de infecciones causadas ... |
Article
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
(Elsevier, 2018-01-01)
Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ... |
Article
Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.
(Frontiers Media, 2018-01-01)
Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of ... |
Article
Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain
(Springer, 2018-01-01)
Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated ... |
| PhD Thesis |
PhD Thesis
 Impacto de la concentración mínima inhibitoria (cmi) y de los puntos de corte clínicos (clsi y eucast) de las combinaciones betalactámicos / inhibidores de betalactamasas en el pronóstico de bacteriemias por enterobacteriaceae
(2017-09-27)
Los puntos de corte clínicos se utilizan para predecir la eficacia terapéutica de un antibiótico cuando se utiliza a la ... |
PhD Thesis
Prevalencia de Escherichia Coli o25b: h4-st131 productor o no de betalactamasa de espectro extendido (BLEE) en Sevilla
(2017-09-14)
Hasta finales de los años 90 K. pneumoniae era la principal enterobacteria implicada en la producción de estas enzimas, ... |
| PhD Thesis |
Article
EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study
(2017-02-07)
Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. ... |
Article
A multinational, preregistered cohort study of β-lactam/β-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-β-lactamase-producing enterobacteriaceae
(American Society for Microbiology, 2016-07-01)
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem ... |
Article
Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli
(American Society for Microbiology, 2016-07-01)
Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently ... |
Article
Modelling the epidemiology of Escherichia coli ST131 and the impact of interventions on the community and healthcare centres
(Cambridge University Press, 2016-01-01)
ST131 Escherichia coli is an emergent clonal group that has achieved successful worldwide spread through a combination of ... |
Article
Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010)
(2016-01-01)
Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by ... |
Article
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
(American Society for Microbiology, 2015-09-01)
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ... |
Article
Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem
(American Society for Microbiology, 2015-06-01)
The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by ... |
PhD Thesis
Tratamiento de bacteriemias por enterobacterias productoras de β-lactamasas de espectro extendido la combinación de β-lactámicosinhibidores de β-lactamasas como alternativa a los carbapenemes. Proyecto INCREMENT
(2015-03-27)
En los últimos años, la diseminación de las enterobacterias productoras de β-lactamasas de espectro extendido (E-BLEE) se ... |
Article
Fosfomycin versus meropenem in bacteraemic urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli (FOREST): study protocol for an investigator-driven randomised controlled trial
(BMJ Publishing Group, 2015-01-01)
Introduction Finding therapeutic alternatives to carbapenems in infections caused by extended-spectrum β-lactamase-producing ... |
PhD Thesis
Estudio clínico y epidemiológico de un brote nosocomial producido por klebsiella oxytoca productora de IMP-8
(2015-01-01)
Klebsiella oxytoca, al igual que K. pneumoniae, son dos patógenos humanos asociados a múltiples cuadros clínicos, pero ... |
PhD Thesis
Interacción de mecanismos plasmídicos y cromosómicos de resistencia a Quinolonas en Escherichia coli y su efecto en la resistencia, fitness y toxicidad celular
(2014-09-18)
Las fluoroquinolonas, junto a los beta-lactámicos, son los antimicrobianos de mayor uso clínico. Por tanto la aparición ... |
PhD Thesis
Estudio multicéntrico de bacteriemias por escherichia coli productor de betalactamasas de espectro extendido: factores de riesgo, características microbiológicas de impacto clínico
(2014-04-02)
Esta tesis es el resultado de un estudio de investigación multicéntrico en el que participaron 13 hospitales y un centro ... |
Article
Global dissemination of a multidrug resistant Escherichia coli clone
(National Academy of Sciences, 2014-04-01)
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a ... |
Article
Epidemiologic and Clinical Impact of Acinetobacter baumannii Colonization and Infection: A Reappraisal
(Lippincott Williams & Wilkins, 2014-01-01)
Acinetobacter baumannii is one of the most important antibiotic-resistant nosocomial bacteria. We investigated changes in ... |
Article
Contribution of Efflux Pumps, Porins, and B-Lactamases to Multidrug Resistance in Clinical Isolates of Acinetobacter baumannii
(American Society for Microbiology, 2013-11-01)
Weinvestigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones ... |
Article
Four main virotypes among extended-spectrum-β-lactamase-producing isolates of Escherichia coli O25b:H4-B2-ST131: bacterial, epidemiological, and clinical characteristics
(American Society for Microbiology, 2013-10-01)
A total of 1,021 extended-spectrum- -lactamase-producing Escherichia coli (ESBLEC) isolates obtained in 2006 during a ... |
Article
Impact of the MIC of Piperacillin-Tazobactam on the Outcome of Patients with Bacteremia Due to Extended-Spectrum-B-Lactamase- Producing Escherichia coli
(American Society for Microbiology, 2013-07-01)
We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to ... |
Article
Epidemiological and Clinical Complexity of Amoxicillin-Clavulanate- Resistant Escherichia coli
(American Society for Microbiology, 2013-07-01)
Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli ... |
Article
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum -Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model
(American Society for Microbiology, 2013-04-01)
Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems ... |
Article
Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study
(Public Library of Science (PLoS), 2013-01-01)
Introduction: Statins have pleiotropic effects that could influence the prevention and outcome of some infectious ... |
Article
Spanish Multicenter Study of the Epidemiology and Mechanisms of Amoxicillin-Clavulanate Resistance in Escherichia coli
(American Society for Microbiology, 2012-07-01)
We conducted a prospective multicenter study in Spain to characterize the mechanisms of resistance to amoxicillin-clavu-lanate ... |
Article
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost
(American Society for Microbiology, 2012-05-01)
To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a ... |
Article
Virulence Profiles of Bacteremic Extended-Spectrum β-Lactamase-Producing Escherichia coli: Association with Epidemiological and Clinical Features
(Public Library of Science, 2012-01-01)
There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused ... |
Article
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
(American Society for Microbiology, 2011-03-01)
This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ... |
Article
Klebsiella pneumoniae Strains Producing Extended-Spectrum B-Lactamases in Spain: Microbiological and Clinical Features
(American Society for Microbiology, 2011-03-01)
Extended-spectrum B-lactamases (ESBL) of the CTX-M, SHV, and TEM families were recognized in 76 (67%), 31 (27%), and 6 ... |
Article
Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6′)-Ib-cr
(American Society for Microbiology, 2011-01-01)
The accuracy of the MicroScan WalkAway, BD Phoenix, and Vitek-2 systems for susceptibility testing of quinolones and ... |
Article
Clinical Features of Infections and Colonization by Acinetobacter Genospecies 3
(American Society for Microbiology, 2010-12-01)
Two hundred twenty-one isolates of Acinetobacter baumannii and 15 of Acinetobacter genospecies 3 (AG3) were consecutively ... |
Article
Long-Term Control of Endemic Hospital-Wide Methicillin-Resistant Staphylococcus aureus (MRSA): The Impact of Targeted Active Surveillance for MRSA in Patients and Healthcare Workers
(Cambridge University Press, 2010-08-01)
To evaluate the long-term impact of successive interventions on rates of methicillin-resistant Staphylococcus aureus (MRSA) ... |
Article
Diversity of Escherichia coli Strains Producing Extended-Spectrum B-Lactamases in Spain: Second Nationwide Study
(American Society for Microbiology, 2010-08-01)
The prevalence of extended-spectrum -lactamase (ESBL)-producing Escherichia coli (ESBLEC) in Spain increased 8-fold from ... |
Article
Risk Factors and Prognosis of Nosocomial Bloodstream Infections Caused by Extended-Spectrum-B-Lactamase-Producing Escherichia coli
(American Society for Microbiology, 2010-05-01)
Extended-spectrum-B-lactamase (ESBL)-producing Escherichia coli (ESBLEC) is an increasing cause of community and nosocomial ... |
PhD Thesis
Bacteriemias por Escherichia coli productor de beta-lactamasas de espectro extendido epidemiología clínica y molecular
(2010-01-01)
Hasta hace poco las infecciones por Escherichia coli productor de BLEE eran infrecuentes, pero en los últimos años estamos ... |
Article
Genetic Variability among ampC Genes from Acinetobacter Genomic Species 3
(American Society for Microbiology, 2009-03-01)
As a part of a nationwide study in Spain, 15 clinical isolates of Acinetobacter genomic species 3 (AG3) were analyzed. The ... |
Article
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
(American Society for Microbiology, 2009-01-01)
We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ... |
Article
Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate
(American Society for Microbiology, 2008-08-01)
Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first ... |
Article
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
(American Society for Microbiology, 2008-01-01)
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ... |
Article
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
(American Society for Microbiology, 2007-06-01)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant ... |
PhD Thesis
Betalactamasas de espectro extendido en enterobacterias aisladas de muestras clínicas de hospitales españoles
(2007-02-06)
En 1985, se describió la primera betalactamasa de espectro extendido (BLEE). En España la primera BLEE fue descrita en ... |
| PhD Thesis |
Article
Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
(American Society for Microbiology, 2006-09-01)
The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 ... |
PhD Thesis
Resistencia a quinolonas mediada por plásmido en enterobacteriaceae
(2006-01-01)
En 1998, se describió por primera vez resistencia a quinolonas transmisible horizontalmente mediante un plásmido conjugativo. ... |
Article
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
(American Society for Microbiology, 2005-08-01)
Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ... |
Article
Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain
(American Society for Microbiology, 2005-05-01)
Clonal dissemination of extended-spectrum -lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae ... |
Article
Clinical features and epidemiology of acinetobacter baumanni colonization and infection in spanish hospitals
(SLACK, 2004-10-01)
OBJECTIVE: To investigate the clinical features and the epidemiology of Acinetobacter baumannii in Spanish hospitals. DESIGN: ... |
Article
Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and b-Lactams in Acinetobacter Genospecies 3
(American Society for Microbiology, 2004-04-01)
Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies ... |
Article
Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients
(American Society for Microbiology, 2004-03-01)
Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in nonhospitalize patients ... |
Article
Type 1 Integrons in Epidemiologically Unrelated Acinetobacter baumannii Isolates Collected at Spanish Hospitals
(American Society for Microbiology, 2004-01-01)
|
Article
Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance
(American Society for Microbiology, 2003-10-01)
To investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various ... |
Article
Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa
(American Society for Microbiology, 2003-07-01)
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters ... |
Article
Activities of ABT-773 against Listeria monocytogenes and coryneform bacteria of clinical interest
(American Society for Microbiology, 2003-04-01)
The in vitro activities of ABT-773 were evaluated against 15 Listeria monocytogenes strains and 196 coryneform bacteria ... |
Article
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002-12-01)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) ... |
Article
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells
(American Society for Microbiology, 2002-12-01)
The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells ... |
PhD Thesis
Mecanismos de resistencia a Carbapenemas en cepas clínicas de Acinetobacter baumannii
(2001-04-25)
En los últimos años se ha producido un incremento significativo en el número de infecciones nosocomiales causadas por cepas ... |
Article
Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
(American Society for Microbiology, 2000-11-09)
The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. ... |
Article
Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles
(American Society for Microbiology, 2000-09-06)
Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, ... |
Article
Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae
(American Society for Microbiology, 1999-07-01)
Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less ... |
Article
Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells
(American Society for Microbiology, 1999-02-15)
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial ... |
Article
Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations
(American Society for Microbiology, 1999-02-01)
The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted ... |
Article
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
(American Society for Microbiology, 1999-01-01)
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) ... |
Article
In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria
(American Society for Microbiology, 1998-12-01)
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except ... |
Article
Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
(American Society for Microbiology, 1998-07-01)
The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of ... |
Article
Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells
(American Society for Microbiology, 1997-02-01)
The penetration of trovafloxacin into human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and ... |
Article
Antimicrobial susceptibility pattern of Corynebacterium striatum
(American Society for Microbiology, 1996-11-01)
The in vitro activities of 16 antimicrobial agents against 86 strains of Corynebacterium striatum were evaluated by ... |
PhD Thesis
Interacción de los macrólidos con la actividad de los leucocitos polimorfonucleares humanos
(1996-10-18)
Los antimicrobianos, además de su acción antibacteriana directa, pueden tener, en su interacción con las células fagocíticas, ... |
Article
Comparison of broth microdilution and E-test for susceptibility testing of Neisseria meningitidis
(American Society for Microbiology, 1996-01-01)
The susceptibilities of 54 clinical isolates of Neisseria meningitidis to penicillin, cefotaxime, ceftriaxone, cefepime, ... |
PhD Thesis
Penetración y actividad intracelular de cinco fluorquinolonas en leucocitos polimorfonucleares humanos
(1994-01-01)
La finalidad de este estudio ha sido determinar la capacidad de un grupo de quinolonas; fluorquinolonas, de penetrar en ... |
Article
Intracellular penetration and activity of BAY Y 3118 in human polymorphonuclear leukocytes
(American Society for Microbiology, 1994-01-01)
The penetration of a new quinolone (BAY Y 3118) into human polymorphonuclear leukocytes (PMNs) was evaluated by a fluorometric ... |
Article
Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes
(American Society for Microbiology, 1993-01-01)
The penetration of fluconazole into human polymorphonuclear leukocytes (PMNs) and tissue culture epithelial cells (McCoy) ... |
| PhD Thesis |
PhD Thesis
Efecto de inhibidores de betalactamasas en la actividad de los leucocitos polimorfonucleares humanos
(1992-02-11)
CONCLUSIONES 1. La exposición de S. aureus no productor de penicilinasa a concentraciones subinhibitorias de amoxicilina ... |
Article
Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells
(American Society for Microbiology, 1992-01-01)
The penetration of sparfloxacin into human neutrophils (PMN) and different tissue culture cells (HEp-2 and McCoy) was ... |
Article
Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells
(American Society for Microbiology, 1990-01-01)
The penetration of an optically active ofloxacin isomer [(-)-ofloxacin] into human neutrophils and different tissue culture ... |
PhD Thesis
Requerimientos opsónicos y adherencia a catéteres plásticos de estafilococo coagulasa negativo
(1985-06-04)
En las últimas décadas, las mayores innovaciones en el campo de la terapéutica se han centrado en el desarrollo de elementos ... |