Artículo
Virulence Profiles of Bacteremic Extended-Spectrum β-Lactamase-Producing Escherichia coli: Association with Epidemiological and Clinical Features
Autor/es | Rodríguez-Baño, Jesús
Mingorance, Jesús Fernández Romero, Natalia Serrano, Lara López Cerero, Lorena Pascual Hernández, Álvaro ESBL-REIPI group |
Departamento | Universidad de Sevilla. Departamento de Microbiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2012 |
Fecha de depósito | 2017-04-10 |
Publicado en |
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Resumen | There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC). A prospective multicenter ... There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC). A prospective multicenter Spanish cohort including 191 cases of BSI due to ESBLEC was studied. Phylogroups and 25 VF genes were investigated by PCR. ESBLEC were classified into clusters according to their virulence profiles. The association of phylogropus, VF, and clusters with epidemiological features were studied using multivariate analysis. Overall, 57.6%, 26.7%, and 15.7% of isolates belonged to A/B1, D and B2 phylogroups, respectively. By multivariate analysis (adjusted OR [95% CI]), virulence cluster C2 was independently associated with urinary tract source (5.05 [0.96-25.48]); cluster C4 with sources other than urinary of biliary tract (2.89 [1.05-7.93]), and cluster C5 with BSI in non-predisposed patients (2.80 [0.99-7.93]). Isolates producing CTX-M-9 group ESBLs and from phylogroup D predominated among cluster C2 and C5, while CTX-M-1 group of ESBL and phylogroup B2 predominantes among C4 isolates. These results suggest that host factors and previous antimicrobial use were more important than phylogroup or specific VF in the occurrence of BSI due to ESBLEC. However, some associations between virulence clusters and some specific epidemiological features were found |
Identificador del proyecto | REIPI RD06/0008
070190 10/02021 10/01955 10/00795 0048/2008 CTS-5259 |
Cita | Rodríguez Baño, J., Mingorance, J., Fernández Romero, N., Serrano, L., López Cerero, L., Pascual Hernández, Á. y ESBL-REIPI group, (2012). Virulence Profiles of Bacteremic Extended-Spectrum β-Lactamase-Producing Escherichia coli: Association with Epidemiological and Clinical Features. Plos One, 7 (9), e44238-1-e44238-9. |
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Virulence profiles.pdf | 257.2Kb | [PDF] | Ver/ | |