• PhD Thesis
  

  Búsqueda de nuevos sustratos de SCF-bTrCP implicados en tumorigénesis 

  Herrero Ruiz, Joaquín (2015-02-10)

  Esta Tesis se centra en la búsqueda de nuevos sustratos de SCFbTrCP, una ligasa de ubicuitina esencial en la regulación ...

• Article
  

  Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute-responsive change in cell morphology 

  Michel, Annika Marisa; Borrero de Acuña, José Manuel; Molinari, Gabriella; Unal, Can Murat; Will, Sabine; Derksen, Elisabeth (WILEY, 2022)

  Infections by the pathogenic gut bacterium Clostridioides difficile cause severe diarrhoeas up to a toxic megacolon and ...

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  Excretion and viability of SARS‑CoV‑2 in feces and its association with the clinical outcome of COVID‑19 

  Cerrada Romero, Cristina; Berastegui-Cabrera, Judith; Camacho-Martínez, Pedro; Goikoetxea Aguirre, Josune; Pérez Palacios, Patricia; Santibáñez, Sonia; Pascual Hernández, Álvaro; Pachón Díaz, Jerónimo; Cordero Matia, María Elisa; Sánchez Céspedes, Javier (Nature Publishing Group, 2022)

  The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we ...

• Article
  

  The Rhizobial Type 3 Secretion System: The Dr. Jekyll and Mr. Hyde in the Rhizobium–Legume Symbiosis 

  Jiménez Guerrero, Irene; Medina Morillas, Carlos; Vinardell González, José María; Ollero Márquez, Francisco Javier; López Baena, Francisco Javier (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Rhizobia are soil bacteria that can establish a symbiotic association with legumes. As a result, plant nodules are formed ...

• Article
  

  Differential expression of the three independent CaM genes coding for an identical protein: Potential relevance of distinct mRNA stability by different codon usage 

  Munk, Mads; Villalobo Polo, Eduardo; Villalobo, Antonio; Berchtold, Martin W. (Elsevier, 2022)

  The Ca2+-sensor protein calmodulin (CaM) is a major regulator of multiple cell functions. A unique and puzzling feature ...

• Article
  

  CON: carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant enterobacterales 

  Rodríguez-Baño, Jesús; Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro (2021-02-24)

  Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone resistant ...

• Article
  

  Prevalence and risk factors for multidrug-resistant organisms colonization in long-term care facilities around the world: a review 

  Rodríguez-Villodres, Ángel; Martín-Gandul, Cecilia; Peñalva, Germán; Guisado-Gil, Ana Belén; Crespo-Rivas, Juan Carlos; Pachón-Ibáñez, María Eugenia; Lepe Jiménez, José Antonio; Cisneros, José Miguel (MDPI, 2021-06-07)

  Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant ...

• Article
  

  SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome 

  Salto-Alejandre, Sonsoles; Berastegui-Cabrera, Judith; Camacho-Martínez, Pedro; Infante-Domínguez, Carmen; Carretero-Ledesma, Marta; Crespo-Rivas, Juan Carlos; Lepe Jiménez, José Antonio; Cisneros, José Miguel; Pachón Díaz, Jerónimo; Cordero Matia, María Elisa; Sánchez-Céspedes, Javier; Barón-Franco, Bosco; Bernabeu Wittel, Máximo; López Cortés, Luis Fernando; Nieto Martín, María Dolores; Romero Rodríguez, María de las Nieves; Ampuero Herrojo, Javier (NATURE PUBLISHING GROUP, 2021)

  The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict ...

• Article
  

  SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Salmonella Type III Secretion Effector SlrP 

  Bullones Bolaños, Andrea Simone; Araujo Garrido, Juan Luis; Fernández García, Jesús; Romero Portillo, Francisco; Bernal Bayard, Joaquín; Ramos Morales, Francisco (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  SlrP is a protein with E3 ubiquitin ligase activity that is translocated by Salmonella enterica serovar Typhimurium into ...

• Article
  

  Consumption of Tritordeum Bread Reduces Immunogenic Gluten Intake without Altering the Gut Microbiota 

  Haro, Carmen; Guzmán López, M. H.; Marín Sanz, M.; Sánchez León, Susana; Vaquero, Luis; Pastor, Jorge; Comino Montilla, Isabel María; Sousa Martín, Carolina; Vivas, Santiago; Landa, Blanca B.; Barro, Francisco (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Gluten proteins are responsible for the wheat breadmaking quality. However, gluten is also related to human pathologies ...

• Article
  

  Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences 

  Álvarez-Marín, Rocío; Lepe Jiménez, José Antonio; Gasch-Blasi, Oriol; Rodríguez Martínez, José Manuel; Calvo-Montes, Jorge; Lara-Contreras, Rosario; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Jiménez-Mejías, Manuel E. (Elsevier, 2021)

  Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ...

• Article
  

  The Rhizobium tropici CIAT 899 NodD2 protein promotes symbiosis and extends rhizobial nodulation range by constitutive nodulation factor synthesis 

  Ayala García, Paula; Jiménez Guerrero, Irene; Jacott, Catherine N.; López Baena, Francisco Javier; Ollero Márquez, Francisco Javier; Cerro Sánchez, Pablo del; Pérez Montaño, Francisco de Asís (Oxford University Press, 2022)

  In the symbiotic associations between rhizobia and legumes, the NodD regulators orchestrate the transcription of the specifc ...

• Article
  

  The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria 

  González-Magaña, Amaia; Altuna, Jon; Queralt-Martín, María; Largo, Eneko; Velázquez, Carmen; Montánchez, Itxaso; Bernal Guzmán, Patricia; Alcaraz, Antonio; Albesa-Jové, David (Nature Publishing Group, 2022)

  The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and ...

• Article
  

  Shared use of mineral supplement in extensive farming and its potential for infection transmission at the wildlife-livestock interface 

  Martínez-Guijosa, Jordi; López-Alonso, Adrián; Gortázar, Christian; Acevedo, Pelayo; Torres Sánchez, María José; Vicente, Joaquín (Springer, 2021)

  Recently, the survival of Mycobacterium bovis on livestock mineral blocks has been confrmed, but little is known about its ...

• Article
  

  Propensity score and desirability of outcome ranking analysis of ertapenem for treatment of nonsevere bacteremic urinary tract infections due to extended-spectrum-beta-lactamase-producing enterobacterales in kidney transplant recipients 

  Gutiérrez Gutiérrez, Belén; Pérez-Nadales, Elena; Pérez-Galera, Salvador; Cordero Matia, María Elisa; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (American Society Microbiology, 2021)

  There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase ...

• Article
  

  Proof‑of‑concept study to quantify changes in intestinal loads of KPC-producing Klebsiella pneumoniae in colonised patients following selective digestive decontamination with oral gentamicin 

  Pérez Nadales, Elena; Natera, Alejandra M.; Recio Rufián, Manuel; Guzmán Puche, Julia; Cano, Ángela; Frutos Adame, Azahara; Castón, Juan José; Elías-López, Cristina; López Cerero, Lorena; Torre-Cisneros, Julian (Elsevier, 2022)

  Objectives To monitor quantitatively the extent of intestinal colonisation by KPC-producing Klebsiella pneumoniae (KPC-Kp) ...

• Article
  

  Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnMVAC13 against clinical isolates of klebsiella pneumoniae 

  Pacios, Olga; Fernández-García, Laura; Bleriot, Inés; Blasco, Lucía; González-Bardanca, Mónica; Pascual Hernández, Álvaro; Tomasa, María (American Society Microbiology, 2021)

  Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different strategies (resistance and ...

• Article
  

  The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection 

  Bleriot, Inés; Blasco, Lucía; Palacios, Olga; Fernández García, Laura; Ambroa, Antón; López, María; Pascual Hernández, Álvaro; Tomás, María (Nature Publishing Group, 2022)

  Since their discovery, toxin-antitoxin (TA) systems have captivated the attention of many scientists. Recent studies have ...

• Article
  

  Standardization of inducer-activated broad host range expression modules: debugging and refactoring an alkane-responsive AlkS/PalkB device 

  Arce Rodríguez, Alejandro; Benedetti, Ilaria; Borrero de Acuña, José Manuel; Silva Rocha, Rafael; Lorenzo, Víctor de (Oxford University Press, 2021-09-17)

  Although inducible heterologous expression systems have been available since the birth of recombinant DNA technology, the ...

• Article
  

  Multicenter Performance Evaluation of MALDI-TOF MS for Rapid Detection of Carbapenemase Activity in Enterobacterales: The Future of Networking Data Analysis With Online Software 

  Gato, Eva; Anantharajah, Ahalieyah; Arroyo, Manuel J.; Artacho, María José; Caballero, Juan de Dios; Candela, Ana; Pascual Hernández, Álvaro; Oviaño, María (Frontiers Media S.A., 2022)

  In this study, we evaluate the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry ...

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