Article
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
Author/s | Pascual Hernández, Álvaro
![]() ![]() ![]() ![]() ![]() ![]() ![]() Rodríguez Martínez, José Manuel ![]() ![]() ![]() ![]() ![]() ![]() ![]() González Velasco, Carmen García Luque, Isabel ![]() ![]() ![]() ![]() ![]() ![]() Cano, María Elicier Martínez Martínez, Luis |
Department | Universidad de Sevilla. Departamento de Microbiología |
Date | 2007-06-01 |
Published in |
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Abstract | The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant ... The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance. |
Project ID. | SAF2005-04704
![]() PI060580 ![]() REIPI RD06/0008 ![]() |
Citation | Pascual Hernández, Á., Rodríguez Martínez, J.M., González Velasco, C., García Luque, I., Cano, M.E. y Martínez Martínez, L. (2007). Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1. Antimicrobial Agents and Chemotherapy, 51 (6), 2236-2239. |
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