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Diversity of Escherichia coli Strains Producing Extended-Spectrum B-Lactamases in Spain: Second Nationwide Study

Opened Access Diversity of Escherichia coli Strains Producing Extended-Spectrum B-Lactamases in Spain: Second Nationwide Study

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Autor: Díaz, Miguel A.
Hernández-Bello, José R.
Rodríguez-Baño, Jesús
Martínez-Martínez, Luis
Calvo, Jorge
Blanco, Jorge
Pascual Hernández, Álvaro
Departamento: Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Microbiología
Fecha: 2010-08
Publicado en: Journal of Clinical Microbiology 48 (8), 2840–2845
Tipo de documento: Artículo
Resumen: The prevalence of extended-spectrum -lactamase (ESBL)-producing Escherichia coli (ESBLEC) in Spain increased 8-fold from 2000 to 2006. ESBL type, clonal relationship, antimicrobial susceptibility, and clinical data about infections caused by ESBLEC are evaluated in a second nationwide study developed in 2006. From 1008 clinical isolates obtained over 2 months from 44 hospitals, 254 were used for further analysis. ESBL production was evaluated by synergy testing, PCR, and sequencing. Antimicrobial activity was evaluated by microdilution. The clonal relationship was evaluated by repetitive extragenic palindromic-PCR (REP-PCR). The O25b subtype and the new afa operon FM955459 were determined by triplex PCR in isolates producing CTX-M-15. Multilocus sequence typing was performed on these isolates. A total of 72% of all ESBLs were of the CTX-M type, 26.8% were of the SHV type, and 1.2% were of the TEM type. The most prevalent ESBLs were CTX-M-14 (119 isolates), SHV-12 (68 isolate...
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Tamaño: 493.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/35183

DOI: 10.1128/JCM.02147-09

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