Listar Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) por título
Mostrando ítems 65-84 de 181
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Histone depletion prevents telomere fusions in pre-senescent cells
(Public Library of Science, 2018-06-07)Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
(Public Library of Science, 2013)DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
(Wiley-Blackwell, 2020)Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...
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Homologous Recombination: To Fork and Beyond
(MDPI, 2018)Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the ...
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Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
(Frontiers Media S.A., 2019-05-16)Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ...
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Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...
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Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
(Springer Verlag, 2011)The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well as the urinary and ...
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Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs
(Elsevier, 2016)Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells ...
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Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid b toxicity
(BioMed Central, 2011)Background: Amyloid beta (Ab) is the main agent responsible for the advent and progression of Alzheimer’s disease. This ...
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Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation
(Elsevier, 2017)The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic ...
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Learning and memory disabilities in IUGR babies: Functional and molecular analysis in a rat model
(John Wiley and Sons Inc., 2017)Introduction: Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve its inherent growth potential, ...
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Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine ...
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Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
(Nature Publishing Group, 2017)Linker histone H1 is an important structural component of chromatin that stabilizes the nucleosome and compacts the ...
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Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
(Company of Biologists, 2017)Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. ...