dc.creator | Silva, Sonia | es |
dc.creator | Pérez de Camino Cantos, Dolores | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2018-11-21T15:34:29Z | |
dc.date.available | 2018-11-21T15:34:29Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Silva, S., Pérez de Camino Cantos, D. y Aguilera López, A. (2018). Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability. Proceedings of the National Academy of Science, 115 (43), 11024-11029. | |
dc.identifier.issn | 0027-8424 | es |
dc.identifier.issn | 1091-6490 | es |
dc.identifier.uri | https://hdl.handle.net/11441/80447 | |
dc.description.abstract | R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological as they are important drivers of genome instability and have been associated with human diseases. The mitochondrial degradosome is a functionally conserved complex from bacteria to human mitochondria. It is composed of the ATP-dependent RNA and DNA helicase SUV3 and the PNPase ribonuclease, playing a central role in mitochondrial RNA surveillance and degradation. Here we describe a new role for the mitochondrial degradosome in preventing the accumulation of pathological R loops in the mitochondrial DNA, in addition to preventing dsRNA accumulation. Our data indicate that, similar to the molecular mechanisms acting in the nucleus, RNA surveillance mechanisms in the mitochondria are crucial to maintain its genome integrity by counteracting pathological R-loop accumulation. | es |
dc.description.sponsorship | European Research Council ERC2014 AdG669898 TARLOOP | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad BFU2013-42918-P, BFU2016-75058-P | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Proceedings of the National Academy of Science, 115 (43), 11024-11029. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | R loops | es |
dc.subject | RNA metabolism | es |
dc.subject | Genome instability | es |
dc.subject | Mitochondrial degradosome | es |
dc.subject | Transcription–replication conflicts | es |
dc.title | Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | ERC2014 AdG669898 TARLOOP | es |
dc.relation.projectID | BFU2013-42918-P | es |
dc.relation.projectID | BFU2016-75058-P | es |
dc.relation.publisherversion | http://dx.doi.org/10.1073/pnas.1807258115 | es |
dc.identifier.doi | 10.1073/pnas.1807258115 | es |
idus.format.extent | 6 p. | es |
dc.journaltitle | Proceedings of the National Academy of Science | es |
dc.publication.volumen | 115 | es |
dc.publication.issue | 43 | es |
dc.publication.initialPage | 11024 | es |
dc.publication.endPage | 11029 | es |
dc.contributor.funder | European Research Council (ERC) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Biología | |