Article
Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin
Author/s | Cruz Gallardo, Isabel
Díaz Moreno, Irene ![]() ![]() ![]() ![]() ![]() ![]() ![]() Díaz Quintana, Antonio Jesús ![]() ![]() ![]() ![]() ![]() ![]() ![]() Velázquez Campoy, Adrián Curd, Rachel D. Rangachari, Caveri Bridsall, Berry Ramos, Andrés Holder, Anthony A. Rosa Acosta, Miguel Ángel de la ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Publication Date | 2013 |
Deposit Date | 2018-02-12 |
Published in |
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Abstract | Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface ... Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugs |
Project ID. | P08-CVI-3876
![]() BIO198 ![]() SAF2011- 26611 ![]() 15354/PI/10 ![]() BFU2010-19451 ![]() U117574558 ![]() U117532067 ![]() |
Citation | Cruz Gallardo, I., Díaz Moreno, I., Díaz Quintana, A.J., Velázquez Campoy, A., Curd, R.D., Rangachari, C.,...,Rosa Acosta, M.Á.d.l. (2013). Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin. Journal of Biological Chemistry, 288 (29), 20896-20907. |
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