Artículo
RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate
Autor/es | García Mauriño, Sofía M.
Rivero Rodríguez, Francisco Velázquez Cruz, Alejandro Hernández Vellisca, Marian Díaz Quintana, Antonio Jesús Rosa Acosta, Miguel Ángel de la Díaz Moreno, Irene |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular Universidad de Sevilla. Departamento de Biología Vegetal y Ecología |
Fecha de publicación | 2017 |
Fecha de depósito | 2017-11-14 |
Publicado en |
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Resumen | mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay ... mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3′ untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Ministerio de Educación, Cultura y Deporte (MECD). España |
Identificador del proyecto | BFU2015-71017-P
FPU013/04373 FPU016/01513 |
Cita | García Mauriño, S.M., Rivero Rodríguez, F., Velázquez Cruz, A., Hernández Vellisca, M., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2017). RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate. Frontiers in Molecular Biosciences, 4 (71), 1-8. |
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