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dc.creatorGarcía Mauriño, Sofía M.es
dc.creatorRivero Rodríguez, Franciscoes
dc.creatorVelázquez Cruz, Alejandroes
dc.creatorHernández Vellisca, Marianes
dc.creatorDíaz Quintana, Antonio Jesúses
dc.creatorRosa Acosta, Miguel Ángel de laes
dc.creatorDíaz Moreno, Irenees
dc.date.accessioned2017-11-14T16:50:07Z
dc.date.available2017-11-14T16:50:07Z
dc.date.issued2017
dc.identifier.citationGarcía Mauriño, S.M., Rivero Rodríguez, F., Velázquez Cruz, A., Hernández Vellisca, M., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2017). RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate. Frontiers in Molecular Biosciences, 4 (71), 1-8.
dc.identifier.issn2296-889Xes
dc.identifier.urihttp://hdl.handle.net/11441/66027
dc.description.abstractmRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3′ untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches.es
dc.description.sponsorshipEspaña, Ministerio de Economía y Competitividad BFU2015-71017-Pes
dc.description.sponsorshipEspaña, Ministerio de Educación, Cultura y Deporte FPU013/04373, FPU016/01513es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Molecular Biosciences, 4 (71), 1-8.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmRNA fatees
dc.subjectpost-transcriptional regulationes
dc.subjectRNA binding proteinses
dc.subjectstabilityes
dc.subjecttranslationes
dc.titleRNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fatees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Vegetal y Ecologíaes
dc.relation.projectIDBFU2015-71017-Pes
dc.relation.projectIDFPU013/04373es
dc.relation.projectIDFPU016/01513es
dc.relation.publisherversionhttp://dx.doi.org/ 10.3389/fmolb.2017.00071es
dc.identifier.doi10.3389/fmolb.2017.00071es
idus.format.extent9 p.es
dc.journaltitleFrontiers in Molecular Bioscienceses
dc.publication.volumen4es
dc.publication.issue71es
dc.publication.initialPage1es
dc.publication.endPage8es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). España
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (MECD). España

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional