Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?
|Author/s||Miguel Rodríguez, Manuel de
Fernández-Santos, José María
Utrilla Alcolea, José Carmelo
Carrillo Vico, Antonio
Conde Amiano, Esperanza
Guerrero Montávez, Juan Miguel
Martín Lacave, Inés María
|Department||Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica
Universidad de Sevilla. Departamento de Bioquímica Médica Molecular e Inmunología
Universidad de Sevilla. Departamento de Biología Celular
|Abstract||Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of ...
Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the possibility that C-cells present TRH-Rs for the autocrine control of its own TRH production. Our results showed consistent expression for both receptors, TRH-R1 and TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC C13 follicular cells. Our data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling.
|Citation||Miguel Rodríguez, M.d., Fernández-Santos, J.M., Utrilla, J.C., Carrillo Vico, A., Borrero, J., Conde Amiano, E.,..., Martín Lacave, I.M.(2005). Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?. Histology and Histopathology, 20 (3), 713-718.|
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