Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

Abstract

The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne- catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperi- dine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases