Artículo
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
Autor/es | Matassini, Camilla
Mirabella, Stefania Goti, Andrea Robina Ramírez, Inmaculada Moreno Vargas, Antonio José Cardona, Francesca |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2015 |
Fecha de depósito | 2016-11-18 |
Publicado en |
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Resumen | The synthesis of new multivalent architectures based on a trihydroxypiperidine
α
-fucosidase inhibitor is reported herein. Tetrava-
lent and nonavalent dendrimers were obtained by means of the click chemistry approach ... The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne- catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperi- dine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases |
Cita | Matassini, C., Mirabella, S., Goti, A., Robina Ramírez, I., Moreno Vargas, A.J. y Cardona, F. (2015). Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar. Beilstein Journal of Organic Chemistry, 11, 2631-2640. |
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