Author profile: Moreno Vargas, Antonio José
Institutional data
| Name | Moreno Vargas, Antonio José |
| Department | Química Orgánica |
| Knowledge area | Química Orgánica |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
24
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No. visits
2453
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No. downloads
1975
| Publications |
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PhD Thesis
 Synthesis of new nampt inhibitors as potential anti-cancer drugs. An approach to antibody-drug conjugates
(2023-01-27)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the biosynthesis of Nicotinamide Adenine ... |
Article
 Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
(Elsevier, 2023-01-01)
Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ... |
Article
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
(Elsevier, 2022-01-01)
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ... |
Article
Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ... |
PhD Thesis
Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas
(2021-07-16)
Los iminoazúcares constituyen la categoría más importante de inhibidores de glicosidasas, sin embargo, su escasa selectividad ... |
PhD Thesis
Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos
(2020-05-24)
En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre ... |
Article
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
(Wiley-Blackwell, 2020-01-01)
An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ... |
Article
Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes
(Elsevier, 2020-01-01)
Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest ... |
| PhD Thesis |
Article
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
(Royal Society of Chemistry, 2019-01-01)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification ... |
Article
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
(Elsevier, 2019-01-01)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ... |
Article
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018-01-01)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ... |
PhD Thesis
Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer
(2017-05-23)
En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ... |
Article
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017-01-01)
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ... |
Article
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015-01-01)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. ... |
Article
Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
(Royal Society of Chemistry: Open Access, 2015-01-01)
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic ... |
Article
Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
(Arkat USA, 2014-01-01)
A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ... |
Article
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
(Thieme Publishing; Georg Thieme Verlag, 2011-01-01)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ... |
Article
Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011-01-01)
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented. |
Article
Total asymmetric synthesis of monosaccharides and analogues
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011-01-01)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid ... |
Article
Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds
(Schweizerische Chemische Gesellschaft, 2011-01-01)
We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest. |
Article
Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases
(2010-01-01)
The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ... |
PhD Thesis
Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas
(2009-03-27)
Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ... |
Article
Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars
(Georg Thieme Verlag, 2006-01-01)
The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology starting ... |
