NameMoreno Vargas, Antonio José
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryCatedrático de Universidad
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PhD Thesis
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Synthesis of new nampt inhibitors as potential anti-cancer drugs. An approach to antibody-drug conjugates

Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Fratta, Simone; Fratta, Simone (2023-01-27)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the biosynthesis of Nicotinamide Adenine ...
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Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer

Fratta, Simone; Fratta, Simone; Biniecka, Paulina; Biniecka, Paulina; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Nahimana, Aimable; Duchosal, Michel A.; Duchosal, Michel A.; Piacente, Francesco; Piacente, Francesco; Bruzzone, Santina; Bruzzone, Santina; Caffa, Irene; Caffa, Irene; Nencioni, Alessio; Nencioni, Alessio; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Elsevier, 2023-01-01)
Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars

Pingitore, Valeria; Pingitore, Valeria; Martínez Bailén, Macarena; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Mészáros, Zuzana; Kulik, Natalia; Kulik, Natalia; Slámová, Kristýna; Slámová, Kristýna; Křen, Vladimír; Křen, Vladimír; Bojarová, Pavla; Bojarová, Pavla; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José (Elsevier, 2022-01-01)
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines

Elías Rodríguez, María del Pilar; Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...
PhD Thesis
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Reacciones Clic y evaluación in situ para la identificación de inhibidores de glicosidasas

Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Pingitore, Valeria; Pingitore, Valeria (2021-07-16)
Los iminoazúcares constituyen la categoría más importante de inhibidores de glicosidasas, sin embargo, su escasa selectividad ...
PhD Thesis
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Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos

Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Gil de Montes Rojas, Enrique; Gil de Montes Rojas, Enrique (2020-05-24)
En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre ...
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Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

Gil de Montes, Enrique; Gil de Montes, Enrique; Istrate, Alena; Istrate, Alena; Navo, Claudio D.; Navo, Claudio D.; Jiménez Moreno, Ester; Jiménez Moreno, Ester; Hoyt, Emily A.; Hoyt, Emily A.; Corzana, Francisco; Corzana, Francisco; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Jiménez Osés, Gonzalo; Jiménez Osés, Gonzalo; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Bernardes, Gonçalo J.L.; Bernardes, Gonçalo J.L. (Wiley-Blackwell, 2020-01-01)
An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ...
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Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes

Martín, Victoria I.; Martín, Victoria I.; López-Cornejo, María del Pilar; López-Cornejo, María del Pilar; López López, Manuel; López López, Manuel; Blanco Arévalo, Daniel; Blanco Arévalo, Daniel; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Angulo, Manuel; Angulo, Manuel; Laschewsky, André; Laschewsky, André; Moyá Morán, María Luisa; Moyá Morán, María Luisa (Elsevier, 2020-01-01)
Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest ...
PhD Thesis
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Diseño y síntesis de derivados mono- y multivalentes de 1,4-iminociclitoles: estudio de sus propiedades como inhibidores de glicosidasas.

Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Martínez Bailen, Macarena; Martínez Bailen, Macarena (2019-04-05)
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Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Gil de Montes Rojas, Enrique; Gil de Montes Rojas, Enrique; Jiménez Moreno, Ester; Jiménez Moreno, Ester; Oliveira, Bruno L.; Oliveira, Bruno L.; Navo, Claudio D.; Navo, Claudio D.; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José (Royal Society of Chemistry, 2019-01-01)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification ...
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Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars

Martínez Bailén, Macarena; Martínez Bailén, Macarena; Jiménez Ortega, Elena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Sanz Aparicio, Julia; Talens Perales, David; Talens Perales, David; Polaina, Julio; Polaina, Julio; Matassini, Camilla; Matassini, Camilla; Cardona, Francesca; Cardona, Francesca; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José (Elsevier, 2019-01-01)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...
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Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry

Elías Rodríguez, María del Pilar; Elías Rodríguez, María del Pilar; Pingitore, Valeria; Pingitore, Valeria; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Ide, Daisuke; Ide, Daisuke; Miyawaki, Shota; Miyawaki, Shota; Kato, Atsushi; Kato, Atsushi; Álvarez González, Eleuterio; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (American Chemical Society, 2018-01-01)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...
PhD Thesis
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Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer

Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Elías Rodríguez, María del Pilar; Elías Rodríguez, María del Pilar (2017-05-23)
En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ...
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Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases

Mirabella, Stefania; Mirabella, Stefania; D'Adamio, Giampiero; D'Adamio, Giampiero; Matassini, Camilla; Matassini, Camilla; Goti, Andrea; Goti, Andrea; Delgado, Sandra; Delgado, Sandra; Gimeno, Ana; Gimeno, Ana; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Šesták, Sergej; Šesták, Sergej; Jiménez Barbero, Jesús; Jiménez Barbero, Jesús; Cardona, Francesca; Cardona, Francesca (Wiley-Blackwell, 2017-01-01)
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...
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Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

Matassini, Camilla; Matassini, Camilla; Mirabella, Stefania; Mirabella, Stefania; Goti, Andrea; Goti, Andrea; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Cardona, Francesca; Cardona, Francesca (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015-01-01)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. ...
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Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Matassini, Camilla; Matassini, Camilla; Marradi, M.; Marradi, M.; Cardona, F.; Cardona, F.; Parmeggiani, C.; Parmeggiani, C.; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Penadés, S.; Penadés, S.; Goti, A.; Goti, A. (Royal Society of Chemistry: Open Access, 2015-01-01)
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic ...
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Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

Elías Rodríguez, María del Pilar; Elías Rodríguez, María del Pilar; Moreno Clavijo, Elena; Moreno Clavijo, Elena; Carrión Jiménez, Sebastián; Carrión Jiménez, Sebastián; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Caffa, I.; Caffa, I.; Montecucco, F.; Montecucco, F.; Cea, M.; Cea, M.; Nencioni, A.; Nencioni, A.; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Arkat USA, 2014-01-01)
A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...
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Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Coste, G.; Coste, G.; Horlacher, T.; Horlacher, T.; Molina Sanz, Lidia; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Seeberger, P.H.; Seeberger, P.H.; Gerber-Lemaire, S.; Gerber-Lemaire, S. (Thieme Publishing; Georg Thieme Verlag, 2011-01-01)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...
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Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors

Moreno Clavijo, Elena; Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Molina Sanz, Lidia; Molina Sanz, Lidia; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011-01-01)
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
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Total asymmetric synthesis of monosaccharides and analogues

Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Moreno Clavijo, Elena; Moreno Clavijo, Elena (Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011-01-01)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid ...
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Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds

Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Clavijo, Elena; Moreno Clavijo, Elena; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Schweizerische Chemische Gesellschaft, 2011-01-01)
We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest.
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Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases

Moreno Clavijo, Elena; Moreno Clavijo, Elena; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Álvarez González, Eleuterio; Álvarez González, Eleuterio; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (2010-01-01)
The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ...
PhD Thesis
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Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas

Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Molina Sanz, Lidia; Molina Sanz, Lidia (2009-03-27)
Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ...
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Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars

Molina, Lidia; Molina, Lidia; Moreno Vargas, Antonio José; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Robina Ramírez, Inmaculada (Georg Thieme Verlag, 2006-01-01)
The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology starting ...