Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
Autor/es | Luna Varo, Rosa María
Japón Rodríguez, Miguel Ángel Sáez, Carmen Domínguez Sánchez, María Salud Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) |
Fecha de publicación | 2011 |
Fecha de depósito | 2015-02-27 |
Publicado en |
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Resumen | One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts ... One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples. |
Cita | Luna Varo, R.M., Japón Rodríguez, M.Á., Sáez, C., Domínguez Sánchez, M.S. y Aguilera López, A. (2011). Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer, 77 (11) |
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