Data

NameLuna Varo, Rosa María
DepartmentGenética
Knowledge areaGenética
Professional categoryProfesora Titular de Universidad
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  Statistics

  • Items

    16

  • Visits

    2378

  • Downloads

    2069

  Publications

 

PhD Thesis
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DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity

Aguilera López, Andrés; Luna Varo, Rosa María; Marchena Cruz, Esther (2021-10-28)
La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops

Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019-01-01)
Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019-01-01)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
PhD Thesis
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Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma

Aguilera López, Andrés; Luna Varo, Rosa María; Salas Armenteros, Irene (2017-09-13)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ...
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Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability

Salas Armenteros, Irene; Pérez Calero, Carmen; Bayona Feliu, Aleix; Tumini, Emanuela; Luna Varo, Rosa María; Aguilera López, Andrés (Wiley-Blackwell, 2017-01-01)
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening

Gavaldá Martín, Sandra; Santos Pereira, José María; García Rubio, María Luisa; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2016-01-01)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ...
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A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions

Santos Pereira, José María; García Rubio, María Luisa; González Aguilera, Cristina; Luna Varo, Rosa María; Aguilera López, Andrés (Oxford University Press, 2014-01-01)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
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R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity

Gavaldá Martín, Sandra; Gallardo, Mercedes; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2013-01-01)
To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ...
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Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011-01-01)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011-01-01)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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Nab2 functions in the metabolism of RNA driven by polymerases II and III

González Aguilera, Cristina; Tous, Cristina; Babiano González, Reyes; Cruz Díaz, Jesús de la; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2011-01-01)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex

Luna Varo, Rosa María; González Aguilera, Cristina; Aguilera López, Andrés (Landes Bioscience, 2009-01-01)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability

González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008-01-01)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
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Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants

Jimeno González, Sonia; Luna Varo, Rosa María; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination

Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
PhD Thesis
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Estudio sobre la función del gen tas14, inducible por estres salino y ácido abscisico en Lycopersicon esculentum

Pintor Toro, José Antonio; Luna Varo, Rosa María (1995-01-01)
La salinidad, presencia de altas concentraciones de sales en los suelos, constituye un problema creciente en la agricultura: ...