Author profile: Luna Varo, Rosa María
Institutional data
| Name | Luna Varo, Rosa María |
| Department | Genética |
| Knowledge area | Genética |
| Professional category | Profesora Titular de Universidad |
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Statistics
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No. publications
19
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No. visits
2803
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No. downloads
2742
| Publications |
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PhD Thesis
 Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs
(2023-04-12)
Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del ... |
Article
 DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023-01-01)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches ... |
PhD Thesis
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
(2021-10-28)
La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ... |
Article
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019-01-01)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ... |
Article
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019-01-01)
Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ... |
PhD Thesis
Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma
(2017-09-13)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ... |
Article
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017-01-01)
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ... |
Article
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
(Public Library of Science, 2016-01-01)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ... |
Article
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014-01-01)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ... |
Article
R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity
(Public Library of Science, 2013-01-01)
To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ... |
Article
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011-01-01)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ... |
Article
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011-01-01)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ... |
Article
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011-01-01)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ... |
Article
Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009-01-01)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ... |
Article
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008-01-01)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ... |
Article
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants
(American Society for Microbiology, 2006-01-01)
THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ... |
Article
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006-01-01)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ... |
Article
Nab2p and the Thp1p-Sac3p Complex Functionally Interact at the Interface between Transcription and mRNA Metabolism
(Elsevier, 2003-01-01)
THP1 is a conserved eukaryotic gene whose null mutations confer, in yeast, transcription and genetic instability phenotypes ... |
PhD Thesis
Estudio sobre la función del gen tas14, inducible por estres salino y ácido abscisico en Lycopersicon esculentum
(1995-01-01)
La salinidad, presencia de altas concentraciones de sales en los suelos, constituye un problema creciente en la agricultura: ... |