Article
Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii
Author/s | García Quintanilla, Meritxell de Jesús
Caro Vega, José Manuel Pulido, Marina R. Moreno Martínez, P. Pachón Díaz, Jerónimo McConnell, Michael J. |
Department | Universidad de Sevilla. Departamento de Microbiología Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2016-08 |
Deposit Date | 2024-06-24 |
Published in |
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Abstract | LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of ... LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of PF-5081090 at 32 mg/liter increased susceptibility to rifampin, vancomycin, azithromycin, imipenem, and amikacin but had no effect on susceptibility to ciprofloxacin and tigecycline. Potentiating existing antibiotics with LpxC inhibitors may represent an alternative treatment strategy for multidrug-resistant A. baumannii. |
Citation | García Quintanilla, M.d.J., Caro Vega, J.M., Pulido, M.R., Moreno Martínez, P., Pachón Díaz, J. y McConnell, M.J. (2016). Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. Antimicrob Agents and Chemotherapy, 60 (8), 5076-5079. https://doi.org/10.1128/AAC.00407-16. |
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