Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii

García Quintanilla, Meritxell de Jesús; Caro Vega, José Manuel; Pulido, Marina R.; Moreno Martínez, P.; Pachón Díaz, Jerónimo; McConnell, Michael J.

doi:10.1128/AAC.00407-16

Artículo

dc.creator	García Quintanilla, Meritxell de Jesús	es
dc.creator	Caro Vega, José Manuel	es
dc.creator	Pulido, Marina R.	es
dc.creator	Moreno Martínez, P.	es
dc.creator	Pachón Díaz, Jerónimo	es
dc.creator	McConnell, Michael J.	es
dc.date.accessioned	2024-06-24T09:42:21Z
dc.date.available	2024-06-24T09:42:21Z
dc.date.issued	2016-08
dc.identifier.citation	García Quintanilla, M.d.J., Caro Vega, J.M., Pulido, M.R., Moreno Martínez, P., Pachón Díaz, J. y McConnell, M.J. (2016). Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. Antimicrob Agents and Chemotherapy, 60 (8), 5076-5079. https://doi.org/10.1128/AAC.00407-16.
dc.identifier.issn	0066-4804	es
dc.identifier.issn	1098-6596	es
dc.identifier.uri	https://hdl.handle.net/11441/160799
dc.description.abstract	LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of PF-5081090 at 32 mg/liter increased susceptibility to rifampin, vancomycin, azithromycin, imipenem, and amikacin but had no effect on susceptibility to ciprofloxacin and tigecycline. Potentiating existing antibiotics with LpxC inhibitors may represent an alternative treatment strategy for multidrug-resistant A. baumannii.	es
dc.description.sponsorship	Consejeria de Empresa, Empleo y Comercio de la Junta de Andalucia PIE CTS2027	es
dc.description.sponsorship	ISCIII European Development Regional Fund, A Way to Achieve Europe	es
dc.description.sponsorship	Spanish Network for Research in Infectious Diseases (REIPI) REIPI RD06/0008/0000	es
dc.description.sponsorship	Subprograma Miguel Servet, Ministerio de Economia y Competitividad CP11/00314	es
dc.description.sponsorship	Subprograma Sara Borrel, Ministerio de Economia y Competitividad	es
dc.format	application/pdf	es
dc.format.extent	4	es
dc.language.iso	eng	es
dc.publisher	American Society for Microbiology	es
dc.relation.ispartof	Antimicrob Agents and Chemotherapy, 60 (8), 5076-5079.
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	LpxC inhibitors	es
dc.subject	Acinetobacter baumannii	es
dc.subject	Antibiotics	es
dc.title	Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Microbiología	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Medicina	es
dc.relation.publisherversion	https://journals.asm.org/doi/epub/10.1128/aac.00407-16	es
dc.identifier.doi	10.1128/AAC.00407-16	es
dc.contributor.group	Universidad de Sevilla. CTS210: Resistencia a Antimicrobianos	es
dc.contributor.group	Universidad de Sevilla. CTS204: Biotecnología Aplicada al Estudio de Enfermedades Infecciosas	es
dc.journaltitle	Antimicrob Agents and Chemotherapy	es
dc.publication.volumen	60	es
dc.publication.issue	8	es
dc.publication.initialPage	5076	es
dc.publication.endPage	5079	es

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