Article
Redox signaling in acute oxygen sensing
Author/s | Gao Chen, Lin
![]() ![]() ![]() ![]() ![]() ![]() ![]() González Rodríguez, Patricia ![]() ![]() ![]() ![]() ![]() Ortega Sáenz, Patricia ![]() ![]() ![]() ![]() ![]() ![]() ![]() López Barneo, José ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Publication Date | 2017-04-26 |
Deposit Date | 2024-05-22 |
Published in |
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Abstract | Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ... Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular mechanisms underlying O2 sensing by glomus cells have, however, remained elusive. Here we discuss recent data demonstrating that ablation of mitochondrial Ndufs2 gene selectively abolishes sensitivity of glomus cells to hypoxia, maintaining responsiveness to hypercapnia or hypoglycemia. These data suggest that reactive oxygen species and NADH generated in mitochondrial complex I during hypoxia are signaling molecules that modulate membrane K+ channels. We propose that the structural substrates for acute O2 sensing in CB glomus cells are “O2-sensing microdomains” formed by mitochondria and neighboring K+ channels in the plasma membrane. |
Funding agencies | Fundación Botín European Research Council (ERC) Ministerio de Economia, Industria y Competitividad (MINECO). España |
Project ID. | PRJ201502629
![]() SAF2012-39343 ![]() PIE 13/0004 ![]() |
Citation | Gao Chen, L., González Rodríguez, P., Ortega Sáenz, P. y López Barneo, J. (2017). Redox signaling in acute oxygen sensing. Redox Biology, 12, 908-915. https://doi.org/10.1016/j.redox.2017.04.033. |
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