NameLópez Barneo, José
DepartmentFisiología Médica y Biofísica
Knowledge areaFisiología
Professional categoryProfesor Emérito
E-mailRequest
           
  • No. publications

    116

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Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model

Villadiego Luque, Francisco Javier; Muñoz-Manchado, Ana B.; Sobrino Cabello, Verónica; Bonilla-Henao, Victoria; Suárez-Luna, Nela; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; López Barneo, José; Toledo Aral, Juan José (MDPI, 2023)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ...
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Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

Villadiego Luque, Francisco Javier; García-Arriaza, Juan; Ramírez Lorca, Reposo; García Swinburn, Roberto; Cabello Rivera, Daniel; Rosales Nieves, Alicia E.; Muñoz Cabello, Ana María; López Barneo, José; Toledo Aral, Juan José (Nature Publishing Group, 2023)
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in ...
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Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice

Jiménez Gómez, Blanca; Ortega Sáenz, Patricia; Gao Chen, Lin; González Rodríguez, Patricia; García-Flores, Paula; Chandel, Navdeep; López Barneo, José (NATURE PUBLISHING GROUP, 2023)
The hypoxic ventilatory response (HVR) is a life-saving reflex, triggered by the activation of chemoreceptor glomus cells ...
PhD Thesis
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Participación de la mitocondria en la biología de los progenitores neurales y la sensibilidad al oxígeno en los quimiorreceptores arteriales

Cabello Rivera, Daniel; López Barneo, José; Muñoz Cabello, Ana María (2022)
Las mitocondrias son orgánulos que asumen tareas muy diversas y de gran relevancia para la célula eucariota y la homeostasis ...
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Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors

Cabello Rivera, Daniel; Ortega Sáenz, Patricia; Gao Chen, Lin; Muñoz Cabello, Ana María; Bonilla-Henao, Victoria; Schumacker, Paul T.; López Barneo, José (National Academy of Sciences, 2022)
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with ...
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Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice

McElroy, Gregory S.; Chakrabarty, Ram P.; D’Alessandro, Karis B.; Vasan, Karthik; Tan, Jerica; Stoolman, Joshua S.; Gao Chen, Lin; López Barneo, José; Navdeep S. (Nature Publishing Group, 2022)
Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. ...
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Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

Chen, Xuyong; Sunkel, Benjamin; Wang, Meng; Kang, Siwen; Wang, Tingting; Gnanaprakasam, J N Rashida; Muñoz Cabello, Ana María; López Barneo, José; Wang, Ruoning (American Association for the Advancement of Science, 2022)
Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, ...
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Editorial: Hypoxia and Cardiorespiratory Control

Okada, Yasumasa; Paton, Julian F.R.; López Barneo, José; Wilson, Richard J.A.; Marina, Nephtali; Pokorski, Mieczyslaw (Frontiers Media, 2021)
To maintain adequate oxygen levels in the body, which is essential for a healthy life, the respiratory and cardiovascular ...
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Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?

Villadiego Luque, Francisco Javier; Ramírez Lorca, Reposo; Cala, Fernando; Labandeira-García, José L.; Esteban, Mariano; Toledo Aral, Juan José; López Barneo, José (Oxford University Press (OUP), 2021)
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Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices

Gao Chen, Lin; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Cell Press, 2021)
Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. ...
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Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency

Al Khazal, Fatimah; Seungwoo, Kang; Holte, Molly Nelson; Choi, Doo-Sup; Singh, Ravinder; Ortega Sáenz, Patricia; López Barneo, José; Maher III, James L. (Federation amer soc exp biol, 2021)
Mutations in any of the genes encoding the four subunits of succinate dehydrogenase (SDH), a mitochondrial membrane-bound ...
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Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1

March Diaz, Rosana; Lara Ureña, Nieves; Romero Molina, Carmen; Heras Garvin, Antonio; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Springer, 2021)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
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Lactate sensing mechanisms in arterial chemoreceptor cells

Torres-Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José (2021)
Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative ...
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Neurotransmitter Modulation of Carotid Body Germinal Niche

Sobrino, Verónica; Platero-Luengo, Aida; Annese, Valentina; Navarro Guerrero, Elena; González Rodríguez, Patricia; López Barneo, José; Pardal Redondo, Ricardo (MDPI AG, 2020)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters ...
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Cellular adaptation to oxygen deficiency beyond the Nobel award

López Barneo, José; Simon, M. Celeste (Willey, 2020)
Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the ...
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Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α

Ortega Sáenz, Patricia; Moreno Domínguez, Alejandro; Gao Chen, Lin; López Barneo, José (Frontiers Research Foundation, 2020)
Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ...
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Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons

Enterría-Morales, Daniel; López-González del Rey, Natalia; Blesa, Javier; López-López, Ivette; Gallet, Sarah; Prévot, Vincent; López Barneo, José; D'Anglemont De Tassigny, Xavier (Oxford University Press, 2020)
Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has been tested in preclinical ...
PhD Thesis
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Interneuronas estriatales productoras de GDNF: características moleculares y rol en la neuroprotección catecolaminérgica

Enterría Morales, Daniel; D'Anglemont De Tassigny, Xavier; López Barneo, José (2019)
Patent. Invention
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Composiciones capaces de modular la estimulación de GDNF endógeno para el tratamiento de enfermedades neurodegenerativas

López Barneo, José; Dánglemont de Tassigny, Xavier; Enterría Morales, Daniel; López López, Ivette (Organización Mundial de la Propiedad Intelectual (OMPI), 2019)
Compuestos y composiciones capaces de modular la estimulación de GDNF endógeno mediante la activación de los genes GPR83, ...
PhD Thesis
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Activación de las células glómicas por hipoxia y lactato: el cuerpo carotídeo como sensor metabólico.

Torres Torrelo, Hortensia; López Barneo, José; Ortega Sáenz, Patricia (2019)
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Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation

Cabello Rivera, Daniel; Sarmiento Soto, Helia; López Barneo, José; Muñoz Cabello, Ana María (Frontiers Research Foundation, 2019)
Neurogenesis in developing and adult mammalian brain is a tightly regulated process that relies on neural stem cell (NSC) ...
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HIF-2a is essential for carotid body development and function

Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells

Gao Chen, Lin; Bonilla Henao, Victoria; García-Flores, Paula; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Wiley, 2017)
Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...
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Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency

Romero Moya, Damià; Santos Ocaña, Carlos; Castaño, Julio; Garrabou, Gloria; Rodríguez Gómez, José Antonio; Ruiz Bonilla, Vanesa; Bueno, Clara; González Rodríguez, Patricia; Giorgetti, Alessandra; Perdiguero, Eusebio; Prieto, Cristina; Moren Núñez, Constanza; Fernández Ayala, Daniel J.; Victoria Cascajo, María; Velasco, Iván; Canals, Josep María; Montero, Raquel; Yubero, Delia; Jou, Cristina; López Barneo, José; Cardellac, Francesc; Muñoz Cánoves, Pura; Artuch, Rafael; Navas, Plácido; Menéndez, Pablo (Wiley-Blackwell, 2017)
Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain ...
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Redox signaling in acute oxygen sensing

Gao Chen, Lin; González Rodríguez, Patricia; Ortega Sáenz, Patricia; López Barneo, José (Elsevier, 2017)
Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions

Lukovic, Dunja; Díez Lloret, Andrea; Stojkovic, Petra; Rodríguez Martínez, Daniel; Rodríguez Jiménez, Francisco Javier; González Rodríguez, P.; López Barneo, José; Moreno Manzano, Victoria; Stojkovic, Miodrag; Bhattacharya, Shomi S.; Erceg, Slaven (Wiley, 2017)
Neural differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can produce a ...
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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017)
Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
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Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion

Ortega Sáenz, Patricia; Macías Gutiérrez, David; Levitsky, Konstantin L.; Rodríguez Gómez, José Antonio; González Rodríguez, Patricia; Bonilla Henao, Victoria; Arias-Mayenco, Ignacio; López Barneo, José (2016)
Biotin is a water-soluble vitamin required for the function of carboxylases as well asfor the regulation of gene expression. ...
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Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.

Enterría Morales, Daniel; López López, Ivette; López Barneo, José; D’Anglemont de Tassigny, Xavier (2016)
Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival ...
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Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors

Navarro Guerrero, Elena; Platero-Luengo, Aida; Linares Clemente, Pedro; Cases, Ildefonso; López Barneo, José; Pardal Redondo, Ricardo (WILEY, 2016)
Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is ...
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Carotid body oxygen sensing and adaptation to hipoxia

López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
PhD Thesis
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Mecanismos moleculares de la sensibilidad aguda al oxígeno en los quimiorreceptores arteriales: función del complejo I mitocondrial

Fernández-Agüera Rodríguez, María del Carmen; López Barneo, José; Gao Chen, Lin (2015)
El oxígeno (O2) es una molécula esencial para la vida de los animales debido a su metabolismo celular aeróbico, ya que la ...
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Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival

D'Anglemont De Tassigny, Xavier; Sirerol-Piquer, M Salomé; Gómez-Pinedo, Ulises; Pardal Redondo, Ricardo; Bonilla, Sonia; Capilla González, Vivian; López Barneo, José (Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory ...
PhD Thesis
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Mecanismos Moleculares de Formación de Tumores en Modelos Genéticos Animales con Defectos Mitocondriales por Deleción del Gen SdhD

Millán Uclés, África; López Barneo, José; Piruat Palomo, José Ignacio (2015)
La disfunción mitocondrial está ampliamente vinculada con la tumorogénesis. Una de las características principales de las ...
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Glucose sensing by carotid body glomus cells: potential implications in disease

Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014)
The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
PhD Thesis
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Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico

Platero-Luengo, Aida; López Barneo, José; Pardal Redondo, Ricardo (2014)
The goal of this doctoral thesis is to achieve a better understanding of the biology and behavior of the recently discovered ...
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An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia

Platero-Luengo, Aida; González-Granero, Susana; Durán Romero, Rocío; Díaz Castro, Blanca; Piruat Palomo, José Ignacio; García-Verdugo, José Manuel; Pardal Redondo, Ricardo; López Barneo, José (CELL PRESS, 2014)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ ...
Article
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Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response

Olmeda, Bárbara; Umstead, Todd M.; Silveyra, Patricia; Pascual Bravo, Alberto; López Barneo, José; Phelps, David S.; Floros, Joanna; Pérez Gil, Jesús (Elsevier, 2014)
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein ...
Article
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Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

Macías, David; Fernández‐Agüera Rodríguez, Mari Carmen; Bonilla Henao, Victoria; López Barneo, José (Wiley, 2014)
Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of ...
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Díaz Castro, Blanca; García Flores, Gloria Paula; Báez Palomo, Alicia; Millán Uclés, África; Pérez Simón, José Antonio; Piruat Palomo, José Ignacio; López Barneo, José (2014)
Patent. Invention
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Procedimiento para detectar el precipitado de x-gal u otros precipitados opacos mediante microscopia confocal

Levitsky, Konstantin L.; Toledo Aral, Juan José; López Barneo, José (Oficina Española de Patentes y Marcas , 2013)
La presente solicitud de patente se refiere a un procedimiento para la obtención de imágenes confocales de la tinción ...
Article
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Age-mediated transcriptomic changes in adult mouse substantia nigra

Gao Chen, Lin; Hidalgo-Figueroa, María; Escudero Cuadrado, Luis María; Díaz Martín, Juan; López Barneo, José; Pascual Bravo, Alberto (2013)
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease ...
Article
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Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections

Levitski, Konstantín; Villadiego Luque, Francisco Javier; López Barneo, José; Toledo Aral, Juan José (2013)
Chapter of Book
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Carotid Body Transplants as a Therapy for Parkinson’s Disease

Villadiego Luque, Francisco Javier; Muñoz Manchado, Ana Belén; Méndez Ferrer, Simón; Toledo Aral, Juan José; López Barneo, José (The Royal Society of Chemistry, 2013)
Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, ...
Article
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia

Romero-Ruiz, Antonio; Bautista, Lucía; Navarro, Virginia; Heras Garvín, Antonio; Castellano Orozco, Antonio Gonzalo; López Barneo, José; Pascual, Alberto (American Society for Biochemistry and Molecular Biology, 2012)
Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...
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Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction

Díaz Castro, Blanca; Pintado, Carmelo Oscar; García Flores, Gloria Paula; López Barneo, José; Piruat Palomo, José Ignacio (2012)
The SDHD gene (subunit D of succinate dehydrogenase) has been shown to be involved in the generation of paragangliomas and ...
PhD Thesis
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Generación y análisis del ratón mutante condicional en la subunidad D del complejo II mitocondrial: efecto sobre el sistema nervioso central y el periférico

Díaz Castro, Blanca; López Barneo, José; Piruat Palomo, José Ignacio (2012)
SDHD es un gen supresor de tumores en humanos. Este gen codifica para una (SDHD) de las cuatro proteínas que forman parte ...
Article
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T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal

Rodríguez Gómez, José Antonio; Levitski, Konstantín; López Barneo, José (2012)
Article
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GDNF Is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after Injury of the nigrostriatal pathway

Hidalgo-Figueroa, María; Bonilla Jiménez, Sonia; Gutiérrez, Francisco; Pascual Bravo, Alberto; López Barneo, José (2012)
Glial cell line-derived neurotrophic factor (GDNF) is absolutely required for survival of dopaminergic (DA) nigrostriatal ...
PhD Thesis
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Participación de hemoproteínas en la función uimiosensora de células neurosecretoras

Marcos Almaraz, María Teresa; López Barneo, José; Pascual Bravo, Alberto (2011)
En los mamíferos existe un sistema homeostático de tejidos con células sensibles a las variaciones en los niveles sanguíneos ...
Chapter of Book
Chapter of Book
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Neuroprotection in Parkinson’s Disease

Pascual Bravo, Alberto; Villadiego Luque, Francisco Javier; Hidalgo-Figueroa, María; Méndez Ferrer, Simón; Gómez Díaz, Raquel; Toledo Aral, Juan José; López Barneo, José (Royal Society of Chemistry, 2011)
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Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α

Abreu Rodríguez, Irene; Sánchez Silva, Rocío; Martins, Ana Paula; Soveral, Graça; Toledo Aral, Juan José; López Barneo, José; Echevarría Irusta, Miriam (2011)
Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported ...
Article
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The carotid body, a neurogenic niche in the adult peripheral nervous system

Pardal Redondo, Ricardo; Ortega Sáenz, Patricia; Durán, Rocío; Platero-Luengo, Aida; López Barneo, José (Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...
Chapter of Book
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Clinical applications of cell therapy

López Barneo, José (Edikamed, 2010)
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First aid kit for hypoxic survival: sensors and strategies

López Barneo, José; Nurse, C.A.; Nilsson, G.E.; Buck, L.T.; Gassmann, M.; Bogdanova, A. Yu. (University of Chicago Press, 2010)
Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral ...
Article
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Carotid body chemosensory responses in mice deficient of TASK channels

Ortega Sáenz, Patricia; Levitski, Konstantín; Marcos Almaraz, María Teresa; Bonilla Henao, Victoria; Pascual Bravo, Alberto; López Barneo, José (2010)
Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) ...
Patent. Invention
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Células madre derivadas del cuerpo carotideo y usos de las mismas

Durán, Rocío; López Barneo, José; Pardal, Ricardo; Ortega Sáenz, Patricia (Oficina Española de Patentes y Marcas , 2009)
Células madre derivadas del cuerpo carotídeo y usos de las mismas caracterizadas porque son positivas para el marcador ...
PhD Thesis
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Hipoxia en cardiomiocitos; regulación de la expresión de la subunidad b1 del canal maxi-k y participación en el precondicionamiento cardíaco

Bautista Borrego, Lucía; Castellano Orozco, Antonio Gonzalo; López Barneo, José (2009)
The presence of maxi-K channels has been reported in the mitochondria of the cardiac myocytes where it plays a cytoprotective ...
Patent. Invention
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Método y kit de diagnóstico para la determinación cuantitativa de la expresión del canal maxi-K

Navarro Antolín, Francisco Javier; Levitsky, Konstantin L.; López Barneo, José; Calderón Sánchez, Eva María; Ordóñez Fernández, Antonio; Villar López, José; Carmona Bernal, Carmen; Capote Gil, Francisco (Oficina Española de Patentes y Marcas (OEPM), 2009)
Método y kit de diagnóstico para la determinación cuantitativa de la expresión del canal maxi-K. La presente invención se ...
Article
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Bishop, Tammie; Gallagher, Denis; Pascual Bravo, Alberto; Lygate, Craig A.; Bono, Joseph P. de; Nicholls, Lynn G.; Ortega Sáenz, Patricia; Oster, Henrik; Wijeyekoon, Bhathiya; Sutherland, Andrew I.; Grosfeld, Alexandra; Aragones, Julian; Schneider, Martin; Geyte, Katie van; Teixeira, Dania; Diez Juan, Antonio; López Barneo, José; Channon, Keith M.; Maxwell, Patrick H.; Pugh, Christopher W.; Davies, Alun M.; Carmeliet, Peter; Ratcliffe, Peter J. (2008)
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the ...
PhD Thesis
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GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular

Villadiego Luque, Francisco Javier; López Barneo, José; Toledo Aral, Juan José (2007)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares ...
PhD Thesis
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Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1

Muñoz Cabello, Ana María; Echevarría Irusta, Miriam; López Barneo, José; Toledo Aral, Juan José (2007)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción ...
Article
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Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression

Echevarría Irusta, Miriam; Muñoz Cabello, Ana María; Sánchez Silva, Rocío; Toledo Aral, Juan José; López Barneo, José (Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, ...
PhD Thesis
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Neuroprotección en un nuevo modelo de animal transgénico

Mejías Estévez, Rebeca María; Echevarría Irusta, Miriam; López Barneo, José (2006)
El objetivo general de este proyecto fue analizar en un modelo de parkinsonismo experimental en ratones, si el aumento del ...
PhD Thesis
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Acoplamiento excitación-contracción en músculo liso: nuevo papel metabotrópico de los canales de calcio en la regulación del tono vascular

Valle Rodríguez, Alberto del; López Barneo, José; Ureña López, Juan (2006)
El músculo liso es un tejido que se encuentra generalmente recubriendo órganos (músculo liso visceral: tubo digestivo, ...
Article
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Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction

Valle Rodríguez, Alberto del; Calderón Sánchez, Eva María; Ruiz Pérez, Myriam; Ordóñez Guerrero, Antonio; López Barneo, José; Ureña López, Juan (2006)
Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce ...
Presentation
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Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells

López Barneo, José; Ortega Sáenz, Patricia; Piruat Palomo, José Ignacio; García Fernández, María (John Wiley & Sons, 2006)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ...
Article
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Acute oxygen sensing in heme oxygenase-2 null mice

Ortega Sáenz, Patricia; López Barneo, José; Pascual Bravo, Alberto; Gómez Díaz, Raquel (2006)
Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to ...
PhD Thesis
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Regulación de la expresión génica de canales iónicos por hipoxia crónica en células cromafines

Toro Estévez, Raquel del; Chiara, María D.; López Barneo, José (2005)
El objetivo general de este proyecto fue el estudio de la regulación por hipoxia de la expresión de genes que codifican ...
PhD Thesis
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Células neurosecretoras sensoras de oxígeno y glucosa

García Fernández, María; López Barneo, José; Ortega Sáenz, Patricia (2005)
El mantenimiento de un medio interno estable, u homesotasia, es especial para los seres vivos. Por ello existen sistemas ...
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Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors

Muñoz Cabello, Ana María; Toledo Aral, Juan José; López Barneo, José; Echevarría Irusta, Miriam (2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric ...
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Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation

Villadiego Luque, Francisco Javier; Méndez Ferrer, Simón; Valdés Sánchez, Teresa; Silos Santiago, Inmaculada; Fariñas, Isabel; López Barneo, José; Toledo Aral, Juan José (2005)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent ...
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Acute Oxygen-Sensing Mechanisms

Kenneth E., Weir; López Barneo, José; Buckler, Keith J.; Archer, Stephen L. (2005)
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms

E. Kenneth Weir, M.D.; López Barneo, José; Buckler, Keith J.; Stephen L. Archer, M.D (Massachusetts Medical Society, 2005)
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were ...
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Multiple Facets of Maxi-K Channels: The Heme Connection

López Barneo, José; Castellano Orozco, Antonio Gonzalo (2005)
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Regulation of oxygen sensing by ion channels

López Barneo, José; Toro Estévez, Raquel del; Levitski, Konstantín; Chiara, María D.; Ortega Sáenz, Patricia (2004)
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or ...
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The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia

Piruat Palomo, José Ignacio; Óscar Pintado, Carmelo; Ortega Sáenz, Patricia; Roche Molina, Marta; López Barneo, José (2004)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the ...
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells

Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; García Fernández, María; López Barneo, José (Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ...
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Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats

Toledo Aral, Juan José; Méndez Ferrer, Simón; Pardal Redondo, Ricardo; Echevarría Irusta, Miriam; López Barneo, José (2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with ...
PhD Thesis
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Sensibilidad a hipoxia e hipoglucemia de células glómicas en rodajas de cuerpo carotídeo

Pardal Redondo, Ricardo; López Barneo, José (2000)
Los objetivos generales del presente trabajo fueron los siguientes: 1. Puesta a punto de la preparación de rodajas finas ...
PhD Thesis
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Homeostasis del calcio en miocitos del árbol arterial pulmonar

Smani Hajami, Tarik; López Barneo, José; Ureña López, Juan (2000)
En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ...
Patent. Invention
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Método de aislamiento de un agregado celular y agregado celular resultante

Armengol Butrón de Mugica, Jose Angel; López Barneo, José; Fernández-Espejo, Emilio; Montoro Laseca, Rafael Jesús (Oficina Española de Patentes y Marcas , 2000)
Método de aislamiento de un agregado celular y agregado celular resultante.La invención se refiere al uso de células o ...
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Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels

Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; Castellano Orozco, Antonio Gonzalo; López Barneo, José (2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of ...
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Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium

Pardal Redondo, Ricardo; Ludewig, Uwe; García Hirschfeld, Julia; López Barneo, José (2000)
We have developed a thin-slice preparation of whole rat carotid body that allows us to perform patch-clamp recording of ...
Patent. Invention
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Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia

López Barneo, José; Ureña López, Juan; Franco Obregón, Alfredo; Castellano Orozco, Antonio; Montoro Laseca, Rafael; Molina Pachón, Antonio; Ortega Saenz, Patricia (Oficina Española de Patentes y Marcas (OEPM), 1999)
Utilización en composiciones farmacológicas de agentes con efecto reductor o inductor de hipoxia. Se propone como nueva ...
PhD Thesis
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Subunidades α-reguladoras de canales K+; determinantes moleculares de la función Kv2.3

Monje Quiroga, Francisco; López Barneo, José; Chiara, María D. (1999)
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Evolución a largo plazo de trasplantes de cuerpo carotídeo en el estriado de ratas hemiparkinsonianas [Reseñas]

Pardal Redondo, Ricardo; Toledo Aral, Juan José; Montoro, R.J.; Méndez Ferrer, Simón; Fernández-Espejo, Emilio; Armengol Butrón de Mújica, José Ángel; Herrero, M.T.; Nieto, M.A.; López Barneo, José (1999)
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A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating

Chiara, María D.; Monje Quiroga, Francisco; Castellano Orozco, Antonio Gonzalo; López Barneo, José (1999)
Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable ...
PhD Thesis
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Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain

Castellano Orozco, Antonio Gonzalo; Chiara, María D.; Mellström, Britt; Molina, Antonio; Monje Quiroga, Francisco; Naranjo, José R.; López Barneo, José (1997)
The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. ...
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Oxygen sensing by ion channels and chemotransduction in single glomus cells

López Barneo, José; Montoro Laseca, Rafael Jesús; Ureña López, Juan; Fernández-Chacón, Rafael; Álvarez de Toledo Naranjo, Guillermo (1996)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a ...
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Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation

Franco Obregón, Alfredo; Ureña López, Juan; López Barneo, José (1995)
We have investigated the modifications of cytosolic [Ca2+] and the activity of Ca2+ channels in freshly dispersed arterial ...
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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells

Ureña López, Juan; Fernández-Chacón, Rafael; Rodríguez Benot, Alberto; Álvarez de Toledo Naranjo, Guillermo; López Barneo, José (1994)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...
PhD Thesis
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Adaptación y modificaciones de corta y larga duración en la actividad eléctrica de neuronas de la corteza cerebral in vitro

Montoro Laseca, Rafael Jesús; López Barneo, José (1993)
El sistema nervioso central lleva a cabo sus complejas funciones gracias a la actividad armónica de sus unidades básicas, ...
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Gating of O2-sensitive K + Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low PO2

Ganfornina, María Dolores; López Barneo, José (1992)
We have studied the kinetic properties of the O2-sensitive K+ channels (KO2 channels) of dissociated glomus cells from ...
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Potassium Channel Types in Arterial Chemoreceptor Cells and Their Selective Modulation by Oxygen

Ganfornina, María Dolores; López Barneo, José (1992)
Single K+ channel currents were recorded in excised membrane patches from dispersed chemoreceptor cells of the rabbit ...
PhD Thesis
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Canales de calcio de las células glómicas y su modulación por dopamina

Rodríguez Benot, Alberto; López Barneo, José (1991)
El presente trabajo se centra en el estudio de los canales de Ca2+ de alto umbral y de su modulación metabólica y por ...
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Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by 02 tension

Ganfornina, María Dolores; López Barneo, José (1991)
Type I cells of the carotid body are known to participate in the detection of 02 tension in arterial blood but the primary ...
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Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons

López Barneo, José; Castellano Orozco, Antonio Gonzalo (1991)
Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration ...
PhD Thesis
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Efecto de la estimulación eléctrica periférica sobre la evolución del dolor lumbar

Escribano Zafra, Antonio; López Barneo, José (1990)
El presente trabajo trata sobre la evolución del dolor lumbar al ser tratado con estimulación eléctrica periférica ...
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Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons

López Barneo, José; Castellano Orozco, Antonio Gonzalo; Toledo Aral, Juan José (1990)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied ...
PhD Thesis
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Canales iónicos de neuronas septales aisladas: Caracterización electrofisiológica y modulación por TRH y LHRH

Castellano Orozco, Antonio Gonzalo; López Barneo, José (1989)
El presente trabajo continua con una de las líneas de investigación de nuestro grupo que trata del estudio de las propiedades ...
PhD Thesis
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Adaptación morfofuncional renal tras nefrectomía unilateral en el adulto

Torrubia Romero, Francisco Javier; López Barneo, José (1989)
En el presente estudio se analizaron los cambios morfológicos y funcionales del riñón remanente tras la nefrectomía de ...
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Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells

López Barneo, José; Tabares, Lucía; Ureña López, Juan (1989)
The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. ...
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body

Ureña López, Juan; López López, J.; González Montelongo, M. Carmen; López Barneo, José (1989)
Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole ...
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Low pO2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body

López López, J.; González Montelongo, M. Carmen; Ureña López, Juan; López Barneo, José (1989)
The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I ...
PhD Thesis
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Repercusión de las alteraciones en la función respiratoria sobre el síndrome de apnea del sueño

León Jiménez, Antonio; López Barneo, José; Rodríguez Becerra, Eulogio; Castillo Gómez, José (1988)
El síndrome de apnea del sueño (SAS), provoca episodios de desaturación nocturna que a la larga provoca hipertensión ...
PhD Thesis
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Complicaciones pielo-ureterales en el homotransplante renal heterotrópico

Mármol Navarro, Salvador; López Barneo, José (1988)
PhD Thesis
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Sistema para la adquisición, almacenamiento y análisis de corrientes iónicas transmembrana

Ureña López, Juan; López Barneo, José; Mateos Pérez, Juan Carlos (1987)
El objetivo general del presente trabajo ha sido el diseño e implementación de un sistema automatizado para el control del ...
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Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion

Pintado, E.; Dorado, M.E.; Tabares, Lucía; López Barneo, José (1986)
The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...
PhD Thesis
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Electrofisiología de células adrenocorticales: Estudio mediante el registro intracelular y la técnica de “patch clamp”

Tabares, Lucía; López Barneo, José (1985)
El presente trabajo se centra en el estudio de las características electrofisiológicas de células adrenocorticales en ...
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Depolarizing response of rat parathyroid cells to divalent cations

López Barneo, José; Armstrong, Clay M. (1983)
Membrane potentials were recorded from rat parathyroid glands continuously perfused in vitro. At 1 .5 mM external Ca", the ...
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Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp

López Barneo, José; Matteson, Donald R.; Armstrong, Clay M. (1981)
A new voltage-clamp apparatus for the squid axon has been implemented to enable recording of currents through small areas ...
PhD Thesis