Data

NameLópez Barneo, José
DepartmentFisiología Médica y Biofísica
Knowledge areaFisiología
Professional categoryCatedrático de Universidad (V)
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PhD Thesis
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Participación de la mitocondria en la biología de los progenitores neurales y la sensibilidad al oxígeno en los quimiorreceptores arteriales

López Barneo, José; Muñoz Cabello, Ana María; Cabello Rivera, Daniel (2022-01-14)
Las mitocondrias son orgánulos que asumen tareas muy diversas y de gran relevancia para la célula eucariota y la homeostasis ...
Article
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Neurotransmitter Modulation of Carotid Body Germinal Niche

Sobrino, Verónica; Platero-Luengo, Aida; Annese, Valentina; Navarro Guerrero, Elena; González Rodríguez, Patricia; López Barneo, José; Pardal Redondo, Ricardo (MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters ...
PhD Thesis
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Interneuronas estriatales productoras de GDNF: características moleculares y rol en la neuroprotección catecolaminérgica

D'Anglemont De Tassigny, Xavier; López Barneo, José; Enterría Morales, Daniel (2019-05-23)
PhD Thesis
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Activación de las células glómicas por hipoxia y lactato: el cuerpo carotídeo como sensor metabólico.

López Barneo, José; Ortega Sáenz, Patricia; Torres Torrelo, Hortensia (2019-01-10)
Article
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HIF-2a is essential for carotid body development and function

Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018-04-19)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
Article
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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017-01-01)
Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
Article
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Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions

Lukovic, Dunja; Díez Lloret, Andrea; Stojkovic, Petra; Rodríguez Martínez, Daniel; Rodríguez Jiménez, Francisco Javier; González Rodríguez, P.; López Barneo, José; Moreno Manzano, Victoria; Stojkovic, Miodrag; Bhattacharya, Shomi S.; Erceg, Slaven (Wiley, 2017-01-01)
Neural differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can produce a ...
Article
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Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan- Neuronal Activation in the Female Mouse.

Enterría Morales, Daniel; López López, Ivette; López Barneo, José; D’Anglemont de Tassigny, Xavier (2016-10-14)
Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival ...
Article
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Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors

Navarro Guerrero, Elena; Platero-Luengo, Aida; Linares Clemente, Pedro; Cases, Ildefonso; López Barneo, José; Pardal Redondo, Ricardo (WILEY, 2016-01-01)
Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is ...
Article
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Carotid body oxygen sensing and adaptation to hipoxia

López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015-09-01)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
PhD Thesis
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Mecanismos moleculares de la sensibilidad aguda al oxígeno en los quimiorreceptores arteriales: función del complejo I mitocondrial

López Barneo, José; Gao Chen, Lin; Fernández-Agüera Rodríguez, María del Carmen (2015-06-17)
El oxígeno (O2) es una molécula esencial para la vida de los animales debido a su metabolismo celular aeróbico, ya que la ...
PhD Thesis
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Mecanismos Moleculares de Formación de Tumores en Modelos Genéticos Animales con Defectos Mitocondriales por Deleción del Gen SdhD

López Barneo, José; Piruat Palomo, José Ignacio; Millán Uclés, África (2015-01-01)
La disfunción mitocondrial está ampliamente vinculada con la tumorogénesis. Una de las características principales de las ...
Article
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Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival

D'Anglemont De Tassigny, Xavier; Sirerol-Piquer, M Salomé; Gómez-Pinedo, Ulises; Pardal Redondo, Ricardo; Bonilla, Sonia; Capilla-González, Vivian; López Barneo, José (Dove Medical Press Ltd., 2015-01-01)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory ...
Article
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Glucose sensing by carotid body glomus cells: potential implications in disease

Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)
The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
PhD Thesis
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Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico

López Barneo, José; Pardal Redondo, Ricardo; Platero-Luengo, Aida (2014-04-25)
The goal of this doctoral thesis is to achieve a better understanding of the biology and behavior of the recently discovered ...
Article
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An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia

Platero-Luengo, Aida; González-Granero, Susana; Durán Romero, Rocío; Díaz Castro, Blanca; Piruat Palomo, José Ignacio; García-Verdugo, José Manuel; Pardal Redondo, Ricardo; López Barneo, José (CELL PRESS, 2014-01-16)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ ...
Article
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Díaz Castro, Blanca; García Flores, Gloria Paula; Báez Palomo, Alicia; Millán Uclés, África; Pérez Simón, José Antonio; Piruat Palomo, José Ignacio; López Barneo, José (2014-01-01)
Article
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Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia

Macías, David; Fernández‐Agüera Rodríguez, Mari Carmen; Bonilla Henao, Victoria; López Barneo, José (Wiley, 2014-01-01)
Mutations of the von Hippel–Lindau (VHL) gene are associated with pheochromocytomas and paragangliomas, but the role of ...
Article
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Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response

Olmeda, Bárbara; Umstead, Todd M.; Silveyra, Patricia; Pascual Bravo, Alberto; López Barneo, José; Phelps, David S.; Floros, Joanna; Pérez Gil, Jesús (Elsevier, 2014-01-01)
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein ...
Article
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Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections

Levitski, Konstantín; Villadiego Luque, Francisco Javier; López Barneo, José; Toledo Aral, Juan José (2013-01-01)
Article
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Age-mediated transcriptomic changes in adult mouse substantia nigra

Gao Chen, Lin; Hidalgo-Figueroa, María; Escudero Cuadrado, Luis María; Díaz Martín, Juan; López Barneo, José; Pascual Bravo, Alberto (2013-01-01)
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease ...
Article
Chapter of Book
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Carotid Body Transplants as a Therapy for Parkinson’s Disease

Villadiego Luque, Francisco Javier; Muñoz Manchado, Ana Belén; Méndez Ferrer, Simón; Toledo Aral, Juan José; López Barneo, José (The Royal Society of Chemistry, 2013-01-01)
Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, ...
Article
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia

Romero-Ruiz, Antonio; Bautista, Lucía; Navarro, Virginia; Heras Garvín, Antonio; Castellano Orozco, Antonio Gonzalo; López Barneo, José; Pascual, Alberto (American Society for Biochemistry and Molecular Biology, 2012-02-03)
Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...
Article
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GDNF Is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after Injury of the nigrostriatal pathway

Hidalgo-Figueroa, María; Bonilla Jiménez, Sonia; Gutiérrez, Francisco; Pascual Bravo, Alberto; López Barneo, José (2012-01-01)
Glial cell line-derived neurotrophic factor (GDNF) is absolutely required for survival of dopaminergic (DA) nigrostriatal ...
Article
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T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal

Rodríguez Gómez, José Antonio; Levitski, Konstantín; López Barneo, José (2012-01-01)
Article
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Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction

Díaz Castro, Blanca; Pintado, Carmelo Oscar; García Flores, Gloria Paula; López Barneo, José; Piruat Palomo, José Ignacio (2012-01-01)
The SDHD gene (subunit D of succinate dehydrogenase) has been shown to be involved in the generation of paragangliomas and ...
PhD Thesis
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Generación y análisis del ratón mutante condicional en la subunidad D del complejo II mitocondrial: efecto sobre el sistema nervioso central y el periférico

López Barneo, José; Piruat Palomo, José Ignacio; Díaz Castro, Blanca (2012-01-01)
SDHD es un gen supresor de tumores en humanos. Este gen codifica para una (SDHD) de las cuatro proteínas que forman parte ...
PhD Thesis
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Participación de hemoproteínas en la función uimiosensora de células neurosecretoras

López Barneo, José; Pascual Bravo, Alberto; Marcos Almaraz, María Teresa (2011-09-26)
En los mamíferos existe un sistema homeostático de tejidos con células sensibles a las variaciones en los niveles sanguíneos ...
Article
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Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α

Abreu Rodríguez, Irene; Sánchez Silva, Rocío; Martins, Ana Paula; Soveral, Graça; Toledo Aral, Juan José; López Barneo, José; Echevarría Irusta, Miriam (2011-01-01)
Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported ...
Chapter of Book
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Neuroprotection in Parkinson’s Disease

Pascual Bravo, Alberto; Villadiego Luque, Francisco Javier; Hidalgo-Figueroa, María; Méndez Ferrer, Simón; Gómez Díaz, Raquel; Toledo Aral, Juan José; López Barneo, José (Royal Society of Chemistry, 2011-01-01)
Chapter of Book
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La fisiología celular, los canales iónicos y la creación de una biofísica española

López Barneo, José (Manuel Cortijo Mérida, 2011-01-01)
Article
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Carotid body chemosensory responses in mice deficient of TASK channels

Ortega Sáenz, Patricia; Levitski, Konstantín; Marcos Almaraz, María Teresa; Bonilla Henao, Victoria; Pascual Bravo, Alberto; López Barneo, José (2010-01-01)
Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) ...
Chapter of Book
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Clinical applications of cell therapy

López Barneo, José (Edikamed, 2010-01-01)
Article
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First aid kit for hypoxic survival: sensors and strategies

López Barneo, José; Nurse, C.A.; Nilsson, G.E.; Buck, L.T.; Gassmann, M.; Bogdanova, A. Yu. (University of Chicago Press, 2010-01-01)
Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral ...
PhD Thesis
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Hipoxia en cardiomiocitos; regulación de la expresión de la subunidad b1 del canal maxi-k y participación en el precondicionamiento cardíaco

Castellano Orozco, Antonio Gonzalo; López Barneo, José; Bautista Borrego, Lucía (2009-03-09)
The presence of maxi-K channels has been reported in the mitochondria of the cardiac myocytes where it plays a cytoprotective ...
Article
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Bishop, Tammie; Gallagher, Denis; Pascual Bravo, Alberto; Lygate, Craig A.; Bono, Joseph P. de; Nicholls, Lynn G.; Ortega Sáenz, Patricia; Oster, Henrik; Wijeyekoon, Bhathiya; Sutherland, Andrew I.; Grosfeld, Alexandra; Aragones, Julian; Schneider, Martin; Geyte, Katie van; Teixeira, Dania; Diez Juan, Antonio; López Barneo, José; Channon, Keith M.; Maxwell, Patrick H.; Pugh, Christopher W.; Davies, Alun M.; Carmeliet, Peter; Ratcliffe, Peter J. (2008-01-01)
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the ...
PhD Thesis
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GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular

López Barneo, José; Toledo Aral, Juan José; Villadiego Luque, Francisco Javier (2007-04-19)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares ...
PhD Thesis
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Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1

Echevarría Irusta, Miriam; López Barneo, José; Toledo Aral, Juan José; Muñoz Cabello, Ana María (2007-02-02)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción ...
PhD Thesis
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Neuroprotección en un nuevo modelo de animal transgénico

Echevarría Irusta, Miriam; López Barneo, José; Mejías Estévez, Rebeca María (2006-06-20)
El objetivo general de este proyecto fue analizar en un modelo de parkinsonismo experimental en ratones, si el aumento del ...
PhD Thesis
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Acoplamiento excitación-contracción en músculo liso: nuevo papel metabotrópico de los canales de calcio en la regulación del tono vascular

López Barneo, José; Ureña López, Juan; Valle Rodríguez, Alberto del (2006-01-17)
El músculo liso es un tejido que se encuentra generalmente recubriendo órganos (músculo liso visceral: tubo digestivo, ...
Presentation
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Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells

López Barneo, José; Ortega Sáenz, Patricia; Piruat Palomo, José Ignacio; García Fernández, María (John Wiley & Sons, 2006-01-01)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ...
Article
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Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction

Valle Rodríguez, Alberto del; Calderón Sánchez, Eva María; Ruiz Pérez, Myriam; Ordóñez Guerrero, Antonio; López Barneo, José; Ureña López, Juan (2006-01-01)
Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce ...
Article
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Acute oxygen sensing in heme oxygenase-2 null mice

Ortega Sáenz, Patricia; López Barneo, José; Pascual Bravo, Alberto; Gómez Díaz, Raquel (2006-01-01)
Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to ...
PhD Thesis
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Regulación de la expresión génica de canales iónicos por hipoxia crónica en células cromafines

Chiara, María D.; López Barneo, José; Toro Estévez, Raquel del (2005-12-12)
El objetivo general de este proyecto fue el estudio de la regulación por hipoxia de la expresión de genes que codifican ...
PhD Thesis
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Células neurosecretoras sensoras de oxígeno y glucosa

López Barneo, José; Ortega Sáenz, Patricia; García Fernández, María (2005-04-20)
El mantenimiento de un medio interno estable, u homesotasia, es especial para los seres vivos. Por ello existen sistemas ...
Article
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Multiple Facets of Maxi-K Channels: The Heme Connection

López Barneo, José; Castellano Orozco, Antonio Gonzalo (2005-01-01)
Article
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Acute Oxygen-Sensing Mechanisms

Kenneth E., Weir; López Barneo, José; Buckler, Keith J.; Archer, Stephen L. (2005-01-01)
Article
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Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation

Villadiego Luque, Francisco Javier; Méndez Ferrer, Simón; Valdés Sánchez, Teresa; Silos Santiago, Inmaculada; Fariñas, Isabel; López Barneo, José; Toledo Aral, Juan José (2005-01-01)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent ...
Article
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Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors

Muñoz Cabello, Ana María; Toledo Aral, Juan José; López Barneo, José; Echevarría Irusta, Miriam (2005-01-01)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric ...
Article
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms

E. Kenneth Weir, M.D.; López Barneo, José; Buckler, Keith J.; Stephen L. Archer, M.D (Massachusetts Medical Society, 2005-01-01)
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were ...
Article
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The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia

Piruat Palomo, José Ignacio; Óscar Pintado, Carmelo; Ortega Sáenz, Patricia; Roche Molina, Marta; López Barneo, José (2004-01-01)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the ...
Article
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Regulation of oxygen sensing by ion channels

López Barneo, José; Toro Estévez, Raquel del; Levitski, Konstantín; Chiara, María D.; Ortega Sáenz, Patricia (2004-01-01)
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or ...
Article
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Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats

Toledo Aral, Juan José; Méndez Ferrer, Simón; Pardal Redondo, Ricardo; Echevarría Irusta, Miriam; López Barneo, José (2003-01-01)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with ...
Article
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells

Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; García Fernández, María; López Barneo, José (Wiley-Blackwell Publishing Ltd., 2003-01-01)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from ...
PhD Thesis
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Sensibilidad a hipoxia e hipoglucemia de células glómicas en rodajas de cuerpo carotídeo

López Barneo, José; Pardal Redondo, Ricardo (2000-12-04)
Los objetivos generales del presente trabajo fueron los siguientes: 1. Puesta a punto de la preparación de rodajas finas ...
PhD Thesis
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Homeostasis del calcio en miocitos del árbol arterial pulmonar

López Barneo, José; Ureña López, Juan; Smani Hajami, Tarik (2000-07-24)
En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ...
Article
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Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium

Pardal Redondo, Ricardo; Ludewig, Uwe; García Hirschfeld, Julia; López Barneo, José (2000-01-01)
We have developed a thin-slice preparation of whole rat carotid body that allows us to perform patch-clamp recording of ...
Article
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Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels

Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; Castellano Orozco, Antonio Gonzalo; López Barneo, José (2000-01-01)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of ...
PhD Thesis
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Subunidades α-reguladoras de canales K+; determinantes moleculares de la función Kv2.3

López Barneo, José; Chiara, María D.; Monje Quiroga, Francisco (1999-05-10)
Article
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Evolución a largo plazo de trasplantes de cuerpo carotídeo en el estriado de ratas hemiparkinsonianas [Reseñas]

Pardal Redondo, Ricardo; Toledo Aral, Juan José; Montoro, R.J.; Méndez Ferrer, Simón; Fernández-Espejo, Emilio; Armengol Butrón de Mújica, José Ángel; Herrero, M.T.; Nieto, M.A.; López Barneo, José (1999-01-01)
Article
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A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating

Chiara, María D.; Monje Quiroga, Francisco; Castellano Orozco, Antonio Gonzalo; López Barneo, José (1999-01-01)
Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable ...
PhD Thesis
Article
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Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain

Castellano Orozco, Antonio Gonzalo; Chiara, María D.; Mellström, Britt; Molina, Antonio; Monje Quiroga, Francisco; Naranjo, José R.; López Barneo, José (1997-01-01)
The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. ...
Article
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Oxygen sensing by ion channels and chemotransduction in single glomus cells

López Barneo, José; Montoro Laseca, Rafael Jesús; Ureña López, Juan; Fernández-Chacón, Rafael; Álvarez de Toledo Naranjo, Guillermo (1996-01-01)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a ...
Article
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Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation

Franco Obregón, Alfredo; Ureña López, Juan; López Barneo, José (1995-01-01)
We have investigated the modifications of cytosolic [Ca2+] and the activity of Ca2+ channels in freshly dispersed arterial ...
Article
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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells

Ureña López, Juan; Fernández-Chacón, Rafael; Rodríguez Benot, Alberto; Álvarez de Toledo Naranjo, Guillermo; López Barneo, José (1994-01-01)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...
PhD Thesis
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Adaptación y modificaciones de corta y larga duración en la actividad eléctrica de neuronas de la corteza cerebral in vitro

López Barneo, José; Montoro Laseca, Rafael Jesús (1993-03-04)
El sistema nervioso central lleva a cabo sus complejas funciones gracias a la actividad armónica de sus unidades básicas, ...
Article
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Gating of O2-sensitive K + Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low PO2

Ganfornina, María Dolores; López Barneo, José (1992-01-01)
We have studied the kinetic properties of the O2-sensitive K+ channels (KO2 channels) of dissociated glomus cells from ...
Article
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Potassium Channel Types in Arterial Chemoreceptor Cells and Their Selective Modulation by Oxygen

Ganfornina, María Dolores; López Barneo, José (1992-01-01)
Single K+ channel currents were recorded in excised membrane patches from dispersed chemoreceptor cells of the rabbit ...
PhD Thesis
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Canales de calcio de las células glómicas y su modulación por dopamina

López Barneo, José; Rodríguez Benot, Alberto (1991-07-16)
El presente trabajo se centra en el estudio de los canales de Ca2+ de alto umbral y de su modulación metabólica y por ...
Article
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Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons

López Barneo, José; Castellano Orozco, Antonio Gonzalo (1991-01-01)
Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration ...
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Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by 02 tension

Ganfornina, María Dolores; López Barneo, José (1991-01-01)
Type I cells of the carotid body are known to participate in the detection of 02 tension in arterial blood but the primary ...
PhD Thesis
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Efecto de la estimulación eléctrica periférica sobre la evolución del dolor lumbar

López Barneo, José; Escribano Zafra, Antonio (1990-06-29)
El presente trabajo trata sobre la evolución del dolor lumbar al ser tratado con estimulación eléctrica periférica ...
Article
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Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons

López Barneo, José; Castellano Orozco, Antonio Gonzalo; Toledo Aral, Juan José (1990-01-01)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied ...
PhD Thesis
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Canales iónicos de neuronas septales aisladas: Caracterización electrofisiológica y modulación por TRH y LHRH

López Barneo, José; Castellano Orozco, Antonio Gonzalo (1989-10-02)
El presente trabajo continua con una de las líneas de investigación de nuestro grupo que trata del estudio de las propiedades ...
PhD Thesis
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Adaptación morfofuncional renal tras nefrectomía unilateral en el adulto

López Barneo, José; Torrubia Romero, Francisco Javier (1989-01-30)
En el presente estudio se analizaron los cambios morfológicos y funcionales del riñón remanente tras la nefrectomía de ...
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Low pO2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body

López López, J.; González Montelongo, M. Carmen; Ureña López, Juan; López Barneo, José (1989-01-01)
The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I ...
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body

Ureña López, Juan; López López, J.; González Montelongo, M. Carmen; López Barneo, José (1989-01-01)
Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole ...
Article
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Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells

López Barneo, José; Tabares Domínguez, Lucía; Ureña López, Juan (1989-01-01)
The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. ...
PhD Thesis
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Repercusión de las alteraciones en la función respiratoria sobre el síndrome de apnea del sueño

López Barneo, José; Rodríguez Becerra, Eulogio; Castillo Gómez, José; León Jiménez, Antonio (1988-10-04)
El síndrome de apnea del sueño (SAS), provoca episodios de desaturación nocturna que a la larga provoca hipertensión ...
PhD Thesis
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Complicaciones pielo-ureterales en el homotransplante renal heterotrópico

López Barneo, José; Mármol Navarro, Salvador (1988-01-01)
PhD Thesis
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Sistema para la adquisición, almacenamiento y análisis de corrientes iónicas transmembrana

López Barneo, José; Mateos Pérez, Juan Carlos; Ureña López, Juan (1987-07-04)
El objetivo general del presente trabajo ha sido el diseño e implementación de un sistema automatizado para el control del ...
PhD Thesis
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Electrofisiología de células adrenocorticales: Estudio mediante el registro intracelular y la técnica de “patch clamp”

López Barneo, José; Tabares Domínguez, Lucía (1985-12-16)
El presente trabajo se centra en el estudio de las características electrofisiológicas de células adrenocorticales en ...
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Depolarizing response of rat parathyroid cells to divalent cations

López Barneo, José; Armstrong, Clay M. (1983-01-01)
Membrane potentials were recorded from rat parathyroid glands continuously perfused in vitro. At 1 .5 mM external Ca", the ...
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Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp

López Barneo, José; Matteson, Donald R.; Armstrong, Clay M. (1981-01-01)
A new voltage-clamp apparatus for the squid axon has been implemented to enable recording of currents through small areas ...
PhD Thesis