Artículo
miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
Autor/es | Liu, Chang Hai
Ampuero Herrojo, Javier Gil Gómez, Antonio Montero-Vallejo, Rocío Rojas, Ángela Muñoz Hernández, Rocío Gallego-Durán, Rocío Romero Gómez, Manuel |
Departamento | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2018 |
Fecha de depósito | 2024-01-23 |
Publicado en |
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Resumen | Background & Aims
microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver disease (NAFLD) and have been proposed as useful markers for the diagnosis and stratification of disease severity. We conducted a meta-analysis ... Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver disease (NAFLD) and have been proposed as useful markers for the diagnosis and stratification of disease severity. We conducted a meta-analysis to identify the potential usefulness of miRNA biomarkers in the diagnosis and stratification of NAFLD severity. Methods After a systematic review, circulating miRNA expression consistency and mean fold-changes were analysed using a vote-counting strategy. The sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio and area under the curve (AUC) for the diagnosis of NAFLD or non-alcoholic steatohepatitis (NASH) were pooled using a bivariate meta-analysis. Deeks’ funnel plot was used to assess the publication bias. Results Thirty-seven studies of miRNA expression profiles and six studies of diagnostic accuracy were ultimately included in the quantitative analysis. miRNA-122 and miRNA-192 showed consistent upregulation. miRNA-122 was upregulated in every scenario used to distinguish NAFLD severity. The miRNA expression correlation between the serum and liver tissue was inconsistent across studies. miRNA-122 distinguished NAFLD from healthy controls with an AUC of 0.82 (95% CI 0.75–0.89), and miRNA-34a distinguished non-alcoholic steatohepatitis (NASH) from non-alcoholic fatty liver (NAFL) with an AUC of 0.78 (95% CI 0.67–0.88). Conclusion miRNA-34a, miRNA-122 and miRNA-192 were identified as potential diagnostic markers to segregate NAFL from NASH. Both miRNA-122, in distinguishing NAFLD from healthy controls, and miRNA-34a, in distinguishing NASH from NAFL, showed moderate diagnostic accuracy. miRNA-122 was upregulated in every scenario of NAFL, NASH and fibrosis. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Instituto de Salud Carlos III |
Identificador del proyecto | FIS 2016-01842 |
Cita | Liu, C.H., Ampuero Herrojo, J., Gil Gómez, A., Montero-Vallejo, R., Rojas, Á., Muñoz Hernández, R.,...,Romero Gómez, M. (2018). miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis. Journal of Hepatology, 69 (6), 1335-1348. https://doi.org/10.1016/j.jhep.2018.08.008. |
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10.1016j.jhep.2018.08.008.pdf | 2.109Mb | [PDF] | Ver/ | Versión aceptada |