Perfil del autor: Romero Gómez, Manuel
Datos institucionales
Nombre | Romero Gómez, Manuel |
Departamento | Medicina |
Área de conocimiento | Medicina |
Categoría profesional | Catedrático de Universidad (Pza. V.) |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
137
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Nº visitas
15659
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Nº descargas
31442
Publicaciones |
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Tesis Doctoral
Epigenetic therapy based on micrornas inhibition for the amelioration of masld phenotype
(2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most prevalent liver disorder worldwide. ... |
Artículo
Health-related quality of life in non-alcoholic fatty liver disease: A cross-cultural study between Spain and the United Kingdom
(Public Library Science, 2024)
Background: It is unclear what biopsychosocial factors influence the impact of NAFLD on health-related quality of life ... |
Artículo
The efficacy and safety of granulocyte colony-stimulating factor in the treatment of acute-on-chronic liver failure: A systematic review and meta-analysis
(Public Library Science, 2023)
Background and objectives The safety and efficacy of granulocyte-colony stimulating factor (G-CSF) for the treatment of ... |
Artículo
A second update on mapping the human genetic architecture of COVID-19
(Nature Research, 2023)
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the ... |
Tesis Doctoral
Predictores de reingreso precoz en población con cirrosis hepática
(2023)
La cirrosis hepática es una enfermedad crónica que se asocia a una gran morbi-mortalidad, a menudo con requerimiento de ... |
Tesis Doctoral
Aplicación clínica de la elastografía por resonancia magnética en la enfermedad hepática crónica
(2023)
Aims: Aim 1: Comparing the diagnostic accuracy of magnetic resonance elastography (MRE) with ultrasound elastography and ... |
Artículo
Clinical Utility of Urinary Gluten Immunogenic Peptides in the Follow-up of Patients with Coeliac Disease
(Wiley-Blackwell, 2023)
Background: Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD). and its compliance should ... |
Artículo
Clinical application of Magnetic resonance elastography in hepatocellular carcinoma: From diagnosis to prognosis
(Elsevier, 2023)
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Liver ... |
Artículo
Identification of Potential miRNA-mRNA Regulatory Axis of Intrahepatic cccDNA in Patients with Chronic Hepatitis B Virus Infection in the Grey Zone
(BRIEFLAND, 2023)
Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of the hepatitis ... |
Artículo
Serum lipidome unravels a diagnostic potential in bile acid diarrhoea
(2023)
Objective: Bile acid diarrhoea (BAD) is debilitating yet treatable, but it remains underdiagnosed due to challenging ... |
Artículo
Liver stiffness accuracy by magnetic resonance elastography in histologically proven non-alcoholic fatty liver disease patients: a Spanish cohort
(Editorial Garsi, 2023)
Objectives: to evaluate the performance of magnetic resonance elastography (MRE) to stage liver fibrosis in patients with ... |
Artículo
A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease
(Elsevier, 2023)
Background & Aims: This study assessed the effects of the glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide ... |
Artículo
Oportunistic diagnosis based on age and hepatitis C virus clearance: an essential step to improve the overall health of the liver
(Aran Ediciones S.A., 2023)
Back in January 2022, a The Lancet-European Association for the Study of the Liver (EASL) Commission on the impact of ... |
Artículo
Impacto de la enseñanza integrada de la patología médico-quirúrgica en pequeños grupos basada en la resolución de problemas en el aprendizaje de la medicina
(Universidad de Sevilla, 2023)
Objetivos. El presente proyecto parte de la hipótesis de que un programa docente basado en la enseñanza integrada y en el ... |
Artículo
Role of EpCAM+ CD133+ extracellular vesicles in steatosis to steatohepatitis transition in NAFLD
(Wiley, 2023)
Background and Aims Extracellular vesicles (EVs) have emerged as a potential source of circulating biomarkers in liver ... |
Artículo
Extracellular Vesicles as Biomarkers in Liver Disease
(MDPI, 2022)
Extracellular vesicles (EVs) are membrane-derived vesicles released by a variety of cell types, including hepatocytes, ... |
Artículo
Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception
(Frontiers, 2022)
Purpose: Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on ... |
Tesis Doctoral
Biopsychosocial profile of non-alcoholic fatty liver disease (NAFLD) associated with liver transplantation and prevention of risk factors
(2022)
En la presente Tesis Doctoral se han llevado a cabo un estudio teórico y cinco trabajos empíricos y pioneros que abordan ... |
Artículo
Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis
(Elsevier, 2022)
Background & Aims Hyperammonaemia is central in the pathogenesis of hepatic encephalopathy. It also has pleiotropic ... |
Artículo
A Global Survey of Physicians Knowledge About Nonalcoholic Fatty Liver Disease
(Elsevier, 2022)
Background & Aims Despite rapidly increasing nonalcoholic fatty liver disease (NAFLD) prevalence, providers’ knowledge may ... |
Artículo
Performance of Noninvasive Tests of Fibrosis Among Asians, Hispanic, and non-Hispanic Whites in the STELLAR Trials
(ELSEVIER SCIENCE INC, 2022)
BACKGROUND & AIMS: The effect of race on routinely available noninvasive tests of fibrosis is incompletely under stood. ... |
Artículo
Real-world evidence on non-invasive tests and associated cut-offs used to assess fibrosis in routine clinical practice
(Elsevier, 2022)
Background & Aims Non-invasive tests (NITs) offer a practical solution for advanced fibrosis identification in non-alcoholic ... |
Trabajo Fin de Máster
Papel de la glutaminasa en la progresión de esteatosis a esteatohepatitis
(2022)
La esteatosis hepática metabólica (EHmet) es una enfermedad compleja caracterizada por el acúmulo de grasa en los hepatocitos, ... |
Artículo
Emerging pharmacological treatment options for MAFLD
(2022)
Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated ... |
Artículo
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
(MDPI AG, 2022)
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of ... |
Artículo
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
(Willey, 2022)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we ... |
Artículo
Novel genes and sex differences in COVID-19 severity
(OXFORD UNIV PRESS, 2022)
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases ... |
Artículo
Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival
(MDPI, 2022)
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. ... |
Artículo
The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?
(Elsevier Science BV, 2022)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely underappreciated liver ... |
Artículo
Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
(SPRINGER, 2022)
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust ... |
Artículo
Vitality, mental health and role-physical mediate the influence of coping on depressive symptoms and self-efficacy in patients with non-alcoholic fatty liver disease: a cross-sectional study
(Elsevier, 2022)
Objective: Our aim was to determine whether the association between active coping and depressive symptoms in patients with ... |
Artículo
Glutaminolysis-ammonia-urea Cycle Axis, Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies
(XHP Publishing, 2022)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide, reflecting the current epidemics of ... |
Artículo
Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
(Frontiers Media S.A., 2022)
Tissue-to-tissue crosstalk regulates organ function, according to growing data. This phenomenon is relevant for pancreatic ... |
Artículo
Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance
(Elsevier BV, 2022)
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may ... |
Artículo
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
(Nature Publishing Group, 2022)
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking ... |
Artículo
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
(Elsevier, 2022)
Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation pro ... |
Artículo
A sustainable development goal framework to guide multisectoral action on NAFLD through a societal approach
(Wiley, 2022)
Background Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition that requires a comprehensive and ... |
Artículo
Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis
(WILEY, 2022)
Background and Aims Surrogate endpoints that predict complications are necessary for assessment and approval of NASH ... |
Artículo
Diagnostic accuracy of circulating microRNA in hepatitis B virus-related hepatocellular carcinoma: a meta-analysis based on Asian data
(Aran Ediciones S.A., 2022)
Background and aim: hepatitis B virus (HBV) is the main risk factor for hepatocellular carcinoma (HCC). We performed a ... |
Artículo
A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
(2021)
Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular ... |
Artículo
Clinical and sociodemographic determinants of disease progression in patients with nonalcoholic steatohepatitis in the United States
(Lippincott, Williams & Wilkins, 2021)
One fifth of patients with nonalcoholic fatty liver disease (NAFLD) may progress to nonalcoholic steatohepatitis (NASH), ... |
Artículo
The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma
(Elsevier, 2021)
Background Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of ... |
Artículo
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases
(Frontiers Media, 2021)
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a ... |
Tesis Doctoral
Papel de los microARNs en el diagnóstico del carcinoma hepatocelular relacionado con el virus de la hepatitis B y su papel en la regulación del ADN circular covalente cerrado en pacientes con hepatitis B crónica en la zona gris
(2021)
Antecedentes: La infección por el virus de la hepatitis B (VHB) sigue siendo un problema de salud pública mundial, destacando ... |
Artículo
Co-expression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease
(Elsevier, 2021)
Background & Aims Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes ... |
Artículo
Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease
(Elsevier Science, 2021)
Background Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix ... |
Artículo
Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis
(Elsevier Science, 2021)
Background & Aims Antibiotic prophylaxis reduces the risk of infection and mortality in patients with cirrhosis and acute ... |
Artículo
Mapping the human genetic architecture of COVID-19
(Nature Research, 2021)
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, ... |
Artículo
Wilson's disease: revisiting an old friend
(BAISHIDENG PUBLISHING GROUP INC, 2021)
Wilson's disease (WD) is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs, ... |
Artículo
Management of NAFLD patients with advanced fibrosis
(Wiley-Blackwell, 2021)
The prevalence of non alcoholic fatty liver disease (NAFLD) has increased to 25% in the general population and could double ... |
Artículo
Implementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare system
(MDPI, 2021)
The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the ... |
Artículo
Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects
(2021)
Background and Aim: Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) ... |
Tesis Doctoral
Vasodilatadores arteriales versus venosos en el edema pulmonar agudo con hipertensión arterial en emergencias prehospitalarias
(2021)
La combinación de diuréticos, vasodilatadores venosos y morfina, constituye el tratamientohabitual de los pacientes con ... |
Artículo
Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation
(WILEY, 2021)
In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in ... |
Artículo
Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
(Nature Publishing Group, 2021)
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after ... |
Artículo
Assessing the impact of COVID-19 on liver cancer management (CERO-19)
(Elsevier BV, 2021)
Background & Aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems ... |
Artículo
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
(ELSEVIER SCIENCE BV, 2021)
Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD ... |
Artículo
European 'NAFLD Preparedness Index' - Is Europe ready to meet the challenge of fatty liver disease?
(Elsevier BV, 2021)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity, metabolic syndrome, and ... |
Artículo
Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients
(BAISHIDENG PUBLISHING GROUP INC, 2021)
BACKGROUND The combination of alpha-fetoprotein (AFP) and squamous cell carcinoma antigen immunocomplex (SCCA-IgM) have ... |
Artículo
Impact of COVID-19 on liver disease: From the experimental to the clinic perspective.
(Baishideng Publishing Group Inc, 2021)
Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute ... |
Artículo
Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the fibroblast growth factor 21 locus
(WILEY, 2021)
Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic beneficial effects on metabolism. ... |
Artículo
acNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study
(EClinicalMedicine, 2021)
Background There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in ... |
Artículo
COVID-19 and the liver: the chicken or the egg dilema
(Arán Ediciones, S.L., 2021)
After the publication of our meta-analysis, in which we demonstrated that aspartate aminotransferase (AST), alanine ... |
Artículo
A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH
(Massachusetts Medical Society, 2021)
BACKGROUND Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome ... |
Artículo
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
(Wiley, 2021)
Older patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. ... |
Artículo
Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis
(BMJ PublishIng Group, 2021)
Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The ... |
Artículo
Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: A cost-of-illness analysis
(Wiley-Blackwell, 2021)
Background and aims: Non-alcoholic steatohepatitis (NASH) is a chronic disease that can progress to end-stage liver disease ... |
Artículo
Propuesta de nueva denominación: esteatosis hepática metabólica (EHmet)
(Arán Ediciones, S.L., 2021)
El nombre de una enfermedad no sigue ningún protocolo definido y es habitual la aceptación por parte de la comunidad ... |
Artículo
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis
(2021)
Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2- dimensional ... |
Artículo
Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis
(Nature Publishing Group, 2021)
Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which ... |
Artículo
An experimental DUAL model of advanced liver damage
(John Wiley & Sons, 2021)
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clini ... |
Artículo
A machine learning approach enables quantitative measurement of liver histology and disease monitoring in NASH
(Wiley, 2021)
BACKGROUND AND AIMS: Manual histological assessment is currently the accepted standard for diagnosing and monitoring disease ... |
Artículo
Quality of Life and Coping in Nonalcoholic Fatty Liver Disease: Influence of Diabetes and Obesity
(MDPI, 2021)
Our aim was to analyze how type 2 diabetes and obesity influence quality of life (QoL) and coping in patients with ... |
Artículo
Influence of Psychological Biomarkers on Therapeutic Adherence by Patients with Non-Alcoholic Fatty Liver Disease: A Moderated Mediation Model
(MDPI, 2021)
Our aim was to analyze whether depressive symptoms mediated the association between physical quality of life (QoL) and ... |
Artículo
Overall clinical and economic impact of non-alcoholic fatty liver disease
(Aran Ediciones S.A., 2021)
Objectives: to establish the clinical and economic con sequences (resource utilization and healthcare costs) of non-alcoholic ... |
Artículo
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
(Elsevier Science BV, 2021)
Background & Aims Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic ... |
Artículo
Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
(Aran Ediciones S.A., 2021)
Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact ... |
Artículo
Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain
(Lippincott, Williams & Wilkins, 2020)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) presents many ... |
Artículo
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
(Elsevier, 2020)
Herein, we describe, for the first time, 3 different clinical courses of acute decompensation (AD) of cirrhosis after ... |
Artículo
Stratification of patients in NASH clinical trials: a pitfall for trial success
(Elsevier, 2020)
Identifying the most effective therapeutic intervention in patients with NAFLD is challenging. Precise stratification in ... |
Artículo
The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease
(Elsevier, 2020)
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 ... |
Artículo
Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS
(Elsevier, 2020)
Background & Aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is ... |
Artículo
Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice
(Medycyna Praktyczna, 2020)
Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that encompasses various forms of liver damage not caused ... |
Artículo
A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe
(Elsevier, 2020)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become ... |
Artículo
Cost of non-alcoholic steatohepatitis in Europe and the USA: the GAIN study
(Elsevier BV, 2020)
Background & Aims: Non-alcoholic steatohepatitis (NASH) leads to cirrhosis and is associated with a substantial socioeco- nomic ... |
Artículo
Hepatitis C virus clearance by direct-acting antivirals agents improves endothelial dysfunction and subclinical atherosclerosis: HEPCAR study
(Wolters Kluwer, 2020)
INTRODUCTION: Hepatitis C virus (HCV) infection has been related to increased cardiovascular (CV) risk. The aim of this ... |
Artículo
Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease
(Frontiers Media, 2020)
Background: It is unknown how perceived social support and the progression of liver damage influence the psychosocial ... |
Artículo
Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts
(Aran Ediciones S.A., 2020)
Background: chronic liver disease (CLD) patients often pres ent thrombocytopenia (TCP) and when severe, it may pre vent ... |
Tesis Doctoral
Genes y encefalopatía hepática: propuesta de una huella genética para la valoración del riesgo
(2019)
Introducción y objetivos: Determinar el impacto de los factores genéticos en el desarrollo de encefalopatía hepática (EH) ... |
Artículo
A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
(Nature Research, 2019)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 ... |
Artículo
Analysis of the burden and variability in the management of NAFLD patients in the clinical practice: unifying the required criteria
(Sociedad Española de Patología Digestiva, 2019)
Aim: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in the gastroenterology outpatient clinic and ... |
Artículo
Usefulness of bioelectrical impedance analysis for monitoring patients with refractory ascites
(Sociedad Española de Patología Digestiva, 2019)
Background: bioelectrical impedance analysis is a technique for the determination of the hydropic component. The hydropic ... |
Artículo
Relationship Between Self-Perceived Health, Vitality, and Posttraumatic Growth in Liver Transplant Recipients
(Frontiers Media, 2019)
Our objective was to analyze the differences in posttraumatic growth in 240 liver transplant recipients based on two ... |
Artículo
Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models
(Aran Ediciones S.A., 2019)
Introduction: non-alcoholic fatty liver disease is one of the most prevalent liver disorders in the developed world. ... |
Artículo
Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH)
(Aran Ediciones S.A., 2019)
The Spanish Association for the Study of the Liver (AEEH) is convinced that the elimination of hepatitis C virus (HCV) ... |
Artículo
Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD)
(Aran Ediciones S.A., 2019)
Background: recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, dia betes me llitus, ... |
Tesis Doctoral
Utilidad de la sobrecarga oral de glutamina en la predicción del riesgo y del tipo de encefalopatía hepática.
(2018)
La encefalopatía hepática (EH) es un síndrome neuropsiquiátrico complejo potencialmente reversible que se produce en ... |
Tesis Doctoral
El antígeno de células neoplásicas escamosas (SCCA) solo o formando el complejo SCCA-igM es un biomarcador precoz de carcinoma hepatocelular.
(2018)
Background: Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and is a major health problem. ... |
Artículo
New therapeutic perspectives in non-alcoholic steatohepatitis
(Elsevier, 2018)
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able ... |
Artículo
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy
(Sociedad Española de Patología Digestiva, 2018)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: ... |
Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) ... |
Artículo
Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype
(Elsevier, 2018)
Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we ... |
Artículo
miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
(Elsevier, 2018)
Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver disease (NAFLD) and have been proposed ... |
Artículo
Primary biliary cholangitis in Spain. Results of a Delphi study of epidemiology, diagnosis, follow-up and treatment
(Aran Ediciones S.A., 2018)
Introduction: primary biliary cholangitis (PBC) is a rare disease with limited data regarding its epidemiology and standard ... |
Tesis Doctoral
Non-invasive diagnosis of non-alcoholic fatty liver disease.
(2017)
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist ... |
Artículo
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results
(Lippincott Williams & Wilkins, 2017)
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory ... |
Artículo
A real life study of Helicobacter pylori eradication with bismuth quadruple therapy in naïve and previously treated patients
(Aran Ediciones S.A., 2017)
Objective: To evaluate the efficacy and safety of a quadruple regimen (BMTO) of the “3-in-1 capsule” (containing bismuth ... |
Artículo
Evolution of the incidence of inflammatory bowel disease in Southern Spain
(Aran Ediciones S.A., 2017)
Background: The incidence of inflammatory bowel disease is increasing in Europe and in Spain. However, there is no recent ... |
Artículo
Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets
(PMC, 2016)
Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact ... |
Artículo
Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis
(Thieme Medical Publishers, 2016)
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized ... |
Artículo
A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin
(2016)
Background Access to direct-acting antiviral agents (DAAs) is restricted in some settings; thus, the Euro pean Association ... |
Tesis Doctoral
Impacto de la realización de sesiones interniveles en la detección, diagnóstico y tratamiento de la hepatitis B
(2016)
Objetivos: Conocer el impacto de la realización de sesiones interniveles entre atención primaria y atención hospitalaria ... |
Patente. Invención
Métodos de análisis óptico computarizado de imágenes de MR (resonancia magnética) para cuantificar o determinar lesiones hepáticas
(Oficina Española de Patentes y Marcas , 2016)
Método no invasivo para cuantificar las lesiones del hígado de un sujeto que se sospecha que padece una esteatosis hepática ... |
Tesis Doctoral
Papel de la vía de señalización de la insulina y mTOR en la infección por el virus de la Hepatitis C. Implicación en el desarrollo de carcinoma hepatocelular
(2016)
Introducción El virus de la hepatitis C (VHC) promueve resistencia a la insulina (RI) y el desarrollo de esteatosis. Al ... |
Tesis Doctoral
Diabetes mellitus: impact on the pathophysiology, diagnose and treatment of the hepatic encephalopathy.
(2015)
Encefalopatía hepática La encefalopatía hepática (EH) es un disturbio potencialmente reversible, de causa metabólica, que ... |
Artículo
Síndrome LPAC secundario a deleción del exón 4 del gen ABCB4 en un paciente con hepatitis C
(Arán Ediciones, S. L., 2014)
El síndrome LPAC (low-phospholipid-associated cholelithiasis syndrome) está asociado a mutaciones del gen ABCB4, que ... |
Artículo
La poliquistosis hepática del adulto (PHA) en España: análisis de una encuesta estructurada analizando la experiencia y actitud de los especialistas de digestivo españoles
(Arán Ediciones, S. L, 2014)
Antecedentes: la poliquistosis hepática del adulto (PHA) es una enfermedad rara caracterizada por el engrandecimiento ... |
Artículo
Hypoxic hepatitis as diabetic ketoacidosis complication
(Arán Ediciones, S. L., 2014)
Hypoxic hepatitis (HH) (also known as ischemic hepatitis or shock liver) is characterized by a dramatic but transient ... |
Artículo
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy
(Public Library of Science, 2014)
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity ... |
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Patente. Invención
Uso del compuesto N-fenil-N-(3-metil-2-butenil)tiourea para la elaboración de medicamentos destinados al tratamiento de la encefalopatía hepática
(Oficina Española de Patentes y Marcas (OEPM), 2012)
La presente invención se refiere a una composición farmacéutica que comprende el compuesto N-fenil-N- (3-metil-2-butenil)tiourea ... |
Artículo
Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression
(2012)
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to ... |
Artículo
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy
(2012)
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective ... |
Tesis Doctoral
Estudio de la oxidación de proteínas en ratas con encefalopatía hepática: una aproximación proteómica
(2012)
En esta Tesis se ha estudiado el efecto del estrés oxidativo inducido por un estado de hiperamonemia, utilizando como ... |
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Hepatitis C: crioglobulinemia y linfoma no-Hodgkin
(2008)
La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, ... |
Tesis Doctoral
Papel del IGF-1 en la patogenia de la encefalopatía hepática estudio experimental en ratas sometidas a derivación porto-cava
(2008)
La hepatopatía crónica (HC) se define como la inflamación del hígado de duración superior a seis meses, que se suele ... |
Tesis Doctoral
Papel de la hiperamoniemia sobre la actividad glutaminasa en diferentes tejidos y estrés oxidativo en ratas sometidas a derivación porto-cava
(2006)
Como se sabe a partir de los datos publicados, el amonio es el principal causante de la Encefalopatía Hepática (EH). La ... |
Artículo
Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis
(World Journal of Gastroenterology, 2006)
AIM: To assess whether portacaval anastomosis (PCA) in rats affects the protein expression and/or activity of glutaminase ... |
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Tesis Doctoral
Encefalopatía hepática subclínica: valoración de diferentes métodos diagnósticos y su relación con la fisiopatología
(1996)
La encefalopatía hepática subclínica (EHS) es una nueva forma de encefalopatía hepática, diferente del grado cero de ... |