NameRomero Gómez, Manuel
DepartmentMedicina
Knowledge areaMedicina
Professional categoryCatedrático de Universidad (Pza. V.)
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The efficacy and safety of granulocyte colony-stimulating factor in the treatment of acute-on-chronic liver failure: A systematic review and meta-analysis

Qiu, B.; Liang, J.X.; Romero Gómez, Manuel (Public Library Science, 2023)
Background and objectives The safety and efficacy of granulocyte-colony stimulating factor (G-CSF) for the treatment of ...
PhD Thesis
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Predictores de reingreso precoz en población con cirrosis hepática

Sánchez Torrijos, Yolanda María; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2023)
La cirrosis hepática es una enfermedad crónica que se asocia a una gran morbi-mortalidad, a menudo con requerimiento de ...
PhD Thesis
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Aplicación clínica de la elastografía por resonancia magnética en la enfermedad hepática crónica

Liang, Jiaxu; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2023)
Aims: Aim 1: Comparing the diagnostic accuracy of magnetic resonance elastography (MRE) with ultrasound elastography and ...
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Clinical Utility of Urinary Gluten Immunogenic Peptides in the Follow-up of Patients with Coeliac Disease

Garzón Benavides, Marta; Ruiz Carnicer, Ángela; Segura Montero, Verónica; Fombuena, Blanca; García-Fernández, Francisco-José; Comino Montilla, Isabel María; Argüelles Arias, Federico; Romero Gómez, Manuel; Sousa Martín, Carolina; Pizarro Moreno, Ángeles (Wiley-Blackwell, 2023)
Background: Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD). and its compliance should ...
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Clinical application of Magnetic resonance elastography in hepatocellular carcinoma: From diagnosis to prognosis

Liang, Jiaxu; Ampuero Herrojo, Javier; Castell, Javier; Zhang, Qiong; Zhang, Sijia; Chen, Yong; Romero Gómez, Manuel (Elsevier, 2023)
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Liver ...
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Identification of Potential miRNA-mRNA Regulatory Axis of Intrahepatic cccDNA in Patients with Chronic Hepatitis B Virus Infection in the Grey Zone

Zhang, Wen -Ting; Gil Gómez, Antonio; López Sánchez, Macarena; Pérez del Pulgar, Sofia; Romero Gómez, Manuel; Gao, Shuai-Shuai (BRIEFLAND, 2023)
Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of the hepatitis ...
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Serum lipidome unravels a diagnostic potential in bile acid diarrhoea

Lewinska, Monika; Kårhus, Martin Lund; Ellegaard, Anne-Marie Gade; Romero Gómez, Manuel; Macias, Rocio I R; Andersen, Jesper B.; Knop, Filip Krag (2023)
Objective: Bile acid diarrhoea (BAD) is debilitating yet treatable, but it remains underdiagnosed due to challenging ...
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Liver stiffness accuracy by magnetic resonance elastography in histologically proven non-alcoholic fatty liver disease patients: a Spanish cohort

Lara Romero, Carmen; Liang, Jia-Xu; Fernández-Lizaranzu, Isabel; Ampuero Herrojo, Javier; Castell, Javier; Prado Alba, Carmen del; Romero Gómez, Manuel (Editorial Garsi, 2023)
Objectives: to evaluate the performance of magnetic resonance elastography (MRE) to stage liver fibrosis in patients with ...
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Extracellular Vesicles as Biomarkers in Liver Disease

Muñoz Hernández, Rocío; Rojas, Angela; Gato, Sheila; Gallego, Javier; Gil Gómez, Antonio; Castro, María José; Ampuero Herrojo, Javier; Romero Gómez, Manuel (MDPI, 2022)
Extracellular vesicles (EVs) are membrane-derived vesicles released by a variety of cell types, including hepatocytes, ...
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Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception

Roa-Colomo, Amparo; López Garrido, María Ángeles; Molina-Vallejo, Pilar; Rojas, Angela; González Sánchez, Mercedes; Aranda-García, Violeta; Salmeron, Javier; Romero Gómez, Manuel; Muntané Relat, Jordi; Padillo Ruiz, Francisco Javier; Álamo Martínez, José María; Garrido-Navas, M. Carmen (Frontiers, 2022)
Purpose: Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on ...
PhD Thesis
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Biopsychosocial profile of non-alcoholic fatty liver disease (NAFLD) associated with liver transplantation and prevention of risk factors

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (2022)
En la presente Tesis Doctoral se han llevado a cabo un estudio teórico y cinco trabajos empíricos y pioneros que abordan ...
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Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis

Tranah, Thomas H.; Ballester, María Pilar; Carbonell-Asins, Juan Antonio; Ampuero Herrojo, Javier; Alexandrino, Gonçalo; Caracostea, Andra; Romero Gómez, Manuel; Shawcross, Debbie L. (Elsevier, 2022)
Background & Aims Hyperammonaemia is central in the pathogenesis of hepatic encephalopathy. It also has pleiotropic ...
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A Global Survey of Physicians Knowledge About Nonalcoholic Fatty Liver Disease

Younossi, Zobair M.; Ong, Janus P.; Takahashi, Hirokazu; Yilmaz, Yusuf; Eguc‘hi, Yuichiro; El Kassas, Mohamed; Romero Gómez, Manuel; Stepanova, Maria (Elsevier, 2022)
Background & Aims Despite rapidly increasing nonalcoholic fatty liver disease (NAFLD) prevalence, providers’ knowledge may ...
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Performance of Noninvasive Tests of Fibrosis Among Asians, Hispanic, and non-Hispanic Whites in the STELLAR Trials

Wong, Vincent Wai Sun; Tak, Won Young; Goh, George Boon Bee; Cheng, Pin Nan; Lawitz, Eric J.; Younossi, Zobair M.; Romero Gómez, Manuel; Okanoue, Takeshi (ELSEVIER SCIENCE INC, 2022)
BACKGROUND & AIMS: The effect of race on routinely available noninvasive tests of fibrosis is incompletely under stood. ...
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Real-world evidence on non-invasive tests and associated cut-offs used to assess fibrosis in routine clinical practice

Lazarus, Jeffrey V.; Castera, Laurent; Mark, Henry E.; Allen, Alina M.; Adams, Leon A.; Anstee, Quentin M.; Romero Gómez, Manuel; Tsochatzis, Emmanuel A. (Elsevier, 2022)
Background & Aims Non-invasive tests (NITs) offer a practical solution for advanced fibrosis identification in non-alcoholic ...
Master's Final Project
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Papel de la glutaminasa en la progresión de esteatosis a esteatohepatitis

García Fernández, Vanessa; Romero Gómez, Manuel (2022)
La esteatosis hepática metabólica (EHmet) es una enfermedad compleja caracterizada por el acúmulo de grasa en los hepatocitos, ...
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Emerging pharmacological treatment options for MAFLD

Rojas, Ángela; Lara-Romero, Carmen; Muñoz Hernández, Rocío; Gato, Sheila; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2022)
Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated ...
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Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients

Gil Gómez, Antonio; Rojas, Ángela; García Lozano, María R.; Muñoz Hernández, Rocío; Gallego-Durán, Rocío; Maya Miles, Douglas; Ampuero Herrojo, Javier; Romero Gómez, Manuel (MDPI AG, 2022)
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of ...
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Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles

Martínez-Arranz, Ibon; Bruzzone, Chiara; Noureddin, Mazen; Gil-Redondo, Rubén; Mincholé, Itziar; Bizkarguenaga, Maider; Romero Gómez, Manuel; Mato, José M (Willey, 2022)
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we ...
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Novel genes and sex differences in COVID-19 severity

Cruz, Raquel; Almeida, Silvia Diz de; Heredia, Miguel López; Quintela, Ines; Ceballos, Francisco C.; Pita, Guillermo; Calderón Sandubete, Enrique José; Romero Gómez, Manuel; Carracedo, Angel (OXFORD UNIV PRESS, 2022)
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases ...
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Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival

Loucera, Carlos; Perez-Florido, Javier; Casimiro-Soriguer, Carlos S.; Ortuno, Francisco M.; Carmona, Rosario; Bostelmann, Gerrit; Rodríguez-Baño, Jesús; Romero Gómez, Manuel; Lepe Jiménez, José Antonio; Dopazo, Joaquin (MDPI, 2022)
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. ...
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The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?

Lazarus, Jeffrey V.; Mark, Henry E.; Villota-Rivas, Marcela; Palayew, Adam; Carrieri, Patrizia; Colombo, Massimo; Romero Gómez, Manuel; Gheorghe, Liana (Elsevier Science BV, 2022)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely underappreciated liver ...
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Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD

Ampuero Herrojo, Javier; Gallego Durán, Rocío; Maya Miles, Douglas; Montero, Rocío; Gato, Sheila; Rojas, Ángela; Gil, Antonio; Muñoz, Rocío; Romero Gómez, Manuel (SPRINGER, 2022)
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust ...
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Vitality, mental health and role-physical mediate the influence of coping on depressive symptoms and self-efficacy in patients with non-alcoholic fatty liver disease: a cross-sectional study

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (Elsevier, 2022)
Objective: Our aim was to determine whether the association between active coping and depressive symptoms in patients with ...
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Glutaminolysis-ammonia-urea Cycle Axis, Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

Rojas, Angela; Garcia-Lozano, Maria Rosario; Gil-Gomez, Antonio; Romero Gómez, Manuel; Ampuero Herrojo, Javier (XHP Publishing, 2022)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide, reflecting the current epidemics of ...
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Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver

López-Bermudo, Lucía; Luque Sierra, Amparo; Maya Miles, Douglas; Gallego-Durán, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Frontiers Media S.A., 2022)
Tissue-to-tissue crosstalk regulates organ function, according to growing data. This phenomenon is relevant for pancreatic ...
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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Johnson, Katherine; Leary, Peter J.; Govaere, Olivier; Barter, Matthew J.; Charlton, Sarah H.; Cockell, Simon J.; Romero Gómez, Manuel; Miller, Melissa (Elsevier BV, 2022)
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may ...
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Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation

Gallego Durán, Rocío; Ampuero Herrojo, Javier; Pastor Ramírez, Helena; Álvarez Amor, Leticia; Campo, José Antonio del; Maya Miles, Douglas; Muñoz Hernández, Rocío; Romero Gómez, Manuel (Nature Publishing Group, 2022)
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking ...
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Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Da Silva Lima, Natalia; Fondevila, Marcos F.; Nóvoa, Eva; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Nogueiras, Rubén (Elsevier, 2022)
Background & Aims: Autophagy-related gene 3 (ATG3) is an enzyme mainly known for its actions in the LC3 lipidation pro ...
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A sustainable development goal framework to guide multisectoral action on NAFLD through a societal approach

Lazarus, Jeffrey V.; Mark, Henry E.; Colombo, Massimo; Demaio, Sandro; Dillon, John F.; George, Jacob; Romero Gómez, Manuel; Terry T.K. (Wiley, 2022)
Background Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition that requires a comprehensive and ...
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Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis

Sanyal, Arun J.; Anstee, Quentin M.; Trauner, Michael; Lawitz, Eric J.; Abdelmalek, Manal F.; Ding, Dora; Romero Gómez, Manuel; Myers, Robert P. (WILEY, 2022)
Background and Aims Surrogate endpoints that predict complications are necessary for assessment and approval of NASH ...
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A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Guo, Feifei; Estévez-Vázquez, Esther; Benedé-Ubieto, Raquel; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Nevzorova, Yulia A. (2021)
Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular ...
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Clinical and sociodemographic determinants of disease progression in patients with nonalcoholic steatohepatitis in the United States

Ruiz Casas, Leonardo; Pedra, Gabriel; Shaikh, Anum; Franks, Bethany; Dhillon, Harpal; Da Rocha Fernandes, João Diogo; Romero Gómez, Manuel (Lippincott, Williams & Wilkins, 2021)
One fifth of patients with nonalcoholic fatty liver disease (NAFLD) may progress to nonalcoholic steatohepatitis (NASH), ...
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The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma

Lewinska, Monika; Santos-Laso, Álvaro; Arretxe, Enara; Alonso, Cristina; Zhuravleva, Ekaterina; Jiménez-Agüero, Raúl; Romero Gómez, Manuel; Andersen, Jesper B. (Elsevier, 2021)
Background Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of ...
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Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases

Gallego Durán, Rocío; Montero-Vallejo, Rocío; Maya Miles, Douglas; Lucena, Ana; Martin, Franz; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Frontiers Media, 2021)
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a ...
PhD Thesis
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Papel de los microARNs en el diagnóstico del carcinoma hepatocelular relacionado con el virus de la hepatitis B y su papel en la regulación del ADN circular covalente cerrado en pacientes con hepatitis B crónica en la zona gris

Zhang, Wenting; Romero Gómez, Manuel; Gil Gómez, Antonio (2021)
Antecedentes: La infección por el virus de la hepatitis B (VHB) sigue siendo un problema de salud pública mundial, destacando ...
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Co-expression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease

Hernández-Gea, Virginia; Campreciós, Genis; Betancourt, Fabián; Pérez Campuzano, Valeria; Seijo, Susana; Díaz, Alba; Romero Gómez, Manuel; García-Pagán, Juan Carlos (Elsevier, 2021)
Background & Aims Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes ...
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Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Metwally, Mayada; Bayoumi, Ali; Khan, Anis; Adams, Leon A.; Aller, Rocio; García-Monzón, Carmelo; Romero Gómez, Manuel; Eslam, Mohammed (Elsevier Science, 2021)
Background Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix ...
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Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Martínez, Javier; Hernández-Gea, Virginia; Rodríguez de Santiago, Enrique; Téllez, Luis; Procopet, Bogdan; Giráldez, Álvaro; Romero Gómez, Manuel; Albillos, Agustín (Elsevier Science, 2021)
Background & Aims Antibiotic prophylaxis reduces the risk of infection and mortality in patients with cirrhosis and acute ...
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Wilson's disease: revisiting an old friend

Lucena-Valera, A.; Pérez-Palacios, D.; Muñoz Hernández, Rocío; Romero Gómez, Manuel; Ampuero Herrojo, Javier (BAISHIDENG PUBLISHING GROUP INC, 2021)
Wilson's disease (WD) is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs, ...
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Management of NAFLD patients with advanced fibrosis

Maya Miles, Douglas; Ampuero Herrojo, Javier; Gallego Durán, Rocío; Dingianna, Paola; Romero Gómez, Manuel (Wiley-Blackwell, 2021)
The prevalence of non alcoholic fatty liver disease (NAFLD) has increased to 25% in the general population and could double ...
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Implementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare system

Dopazo, Joaquín; Maya Miles, Douglas; García, Federico; Lorusso, Nicola; Calleja, Miguel Ángel; Pareja, María Jesús; López Miranda, José; Rodríguez-Baño, Jesús; Padillo Ruiz, Francisco Javier; Romero Gómez, Manuel (MDPI, 2021)
The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the ...
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Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects

Ampuero Herrojo, Javier; Aller, Rocío; Gallego Durán, Rocío; Crespo, Javier; Abad, Javier; Romero Gómez, Manuel (2021)
Background and Aim: Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) ...
PhD Thesis
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Vasodilatadores arteriales versus venosos en el edema pulmonar agudo con hipertensión arterial en emergencias prehospitalarias

Gómez Izquierdo, Francisco Javier; Romero Gómez, Manuel; Pujol de la Llave, Emilio (2021)
La combinación de diuréticos, vasodilatadores venosos y morfina, constituye el tratamientohabitual de los pacientes con ...
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Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation

Rey, E.; Ampuero Herrojo, Javier; Molina-Jiménez, F.; García-García, Y.; Muñoz Hernández, Rocío; Romero Gómez, Manuel; García-Monzón, C.; Majano, P.; González-Rodríguez, A. (WILEY, 2021)
In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in ...
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Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Picchio, Camila A; Lens, Sabela; Hernandez-Guerra, Manuel; Arenas, Juan; Andrade, Raúl J.; Crespo, Javier; Romero Gómez, Manuel; Lazarus, Jeffrey V. (Nature Publishing Group, 2021)
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after ...
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Assessing the impact of COVID-19 on liver cancer management (CERO-19)

Muñoz-Martínez, S.; Sapena, V.; Forner, A.; Nault, J. C.; Sapisochin, G.; Rimassa, L.; Romero Gómez, Manuel; Reig, M. (Elsevier BV, 2021)
Background & Aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems ...
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PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Trebicka, Joel; Fernandez, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Win; Gambini, Carmine; Romero Gómez, Manuel; Arroyo, Vicente (ELSEVIER SCIENCE BV, 2021)
Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD ...
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European 'NAFLD Preparedness Index' - Is Europe ready to meet the challenge of fatty liver disease?

Lazarus, J. V.; Palayew, A.; Carrieri, P.; Ekstedt, M.; Marchesini, G.; Novak, K.; Ratziu, V.; Romero Gómez, Manuel; Anstee, Q. M. (Elsevier BV, 2021)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity, metabolic syndrome, and ...
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Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients

Gil Gómez, Antonio; Rojas, Ángela; Gallego Durán, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Pontisso, Patrizia; Liu, Changhai (BAISHIDENG PUBLISHING GROUP INC, 2021)
BACKGROUND The combination of alpha-fetoprotein (AFP) and squamous cell carcinoma antigen immunocomplex (SCCA-IgM) have ...
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Impact of COVID-19 on liver disease: From the experimental to the clinic perspective.

Gato, Sheila; Lucena-Valera, Ana; Muñoz Hernández, Rocío; Sousa, Jose Manuel; Romero Gómez, Manuel; Ampuero Herrojo, Javier (Baishideng Publishing Group Inc, 2021)
Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute ...
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Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the fibroblast growth factor 21 locus

Bayoumi, Ali; Elsayed, Asmaa; Han, Shuanglin; Petta, Salvatore; Adams, Leon A.; Aller, Rocio; Romero Gómez, Manuel; Eslam, Mohammed (WILEY, 2021)
Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic beneficial effects on metabolism. ...
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acNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study

Wu, Xi Xi; Zheng, Kenneth I.; Boursier, Jérôme; Chan, Wah Kheong; Yilmaz, Yusuf; Romero Gómez, Manuel; Zheng, Ming Hua (EClinicalMedicine, 2021)
Background There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in ...
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COVID-19 and the liver: the chicken or the egg dilema

Ampuero Herrojo, Javier; Romero Gómez, Manuel (Arán Ediciones, S.L., 2021)
After the publication of our meta-analysis, in which we demonstrated that aspartate aminotransferase (AST), alanine ...
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A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH

Francque, Sven M.; Bedossa, Pierre; Ratziu, Vlad; Anstee, Quentin M.; Romero Gómez, Manuel; Abdelmalek, Manal F. (Massachusetts Medical Society, 2021)
BACKGROUND Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor is a pan-PPAR (peroxisome ...
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Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old

Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Romero Gómez, Manuel; Ampuero Herrojo, Javier; Rodríguez Seguel, Elisa del Pilar; Cuevas, L. (Wiley, 2021)
Older patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. ...
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Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Mózes, Ferenc Emil; Lee, Jenny A.; Selvaraj, Emmanuel Anandraj; Jayaswal, Arjun Narayan Ajmer; Trauner, Michael; Gómez-González, Emilio; Romero Gómez, Manuel (BMJ PublishIng Group, 2021)
Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The ...
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Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: A cost-of-illness analysis

Schattenberg, Jorn M.; Lazarus, Jeffrey V.; Newsome, Philip N.; Serfaty, Lawrence; Aghemo, Alessio; Augustin, Salvador; Romero Gómez, Manuel; Ratziu, Vlad (Wiley-Blackwell, 2021)
Background and aims: Non-alcoholic steatohepatitis (NASH) is a chronic disease that can progress to end-stage liver disease ...
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Propuesta de nueva denominación: esteatosis hepática metabólica (EHmet)

Romero Gómez, Manuel; Ampuero Herrojo, Javier (Arán Ediciones, S.L., 2021)
El nombre de una enfermedad no sigue ningún protocolo definido y es habitual la aceptación por parte de la comunidad ...
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Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

Selvaraj, Emmanuel Anandraj; Mozes, Ferenc Emil; Ajmer Jayaswal, Arjun Narayan; Zafarmand, Mohammad Hadi; Vali, Yasaman; Lee, Jenny A.; Romero Gómez, Manuel; Ampuero Herrojo, Javier; Gómez-González, Emilio (2021)
Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2- dimensional ...
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Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis

Álvarez-Amor, Leticia; Luque Sierra, Amparo; Cárdenas, Antonio; López-Bermudo, Lucía; López-Beas, Javier; Andújar, Eloísa; Varela Pérez, Lourdes María; Romero Gómez, Manuel; Martín, Franz (Nature Publishing Group, 2021)
Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which ...
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An experimental DUAL model of advanced liver damage

Benedé-Ubieto, Raquel; Estévez-Vázquez, Olga; Guo, Feifei; Chen, Chaobo; Singh, Youvika; Nakaya, Helder I.; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Nevzorova, Yulia A. (John Wiley & Sons, 2021)
Individuals exhibiting an intermediate alcohol drinking pattern in conjunction with signs of metabolic risk present clini ...
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A machine learning approach enables quantitative measurement of liver histology and disease monitoring in NASH

Taylor-Weiner, Amaro; Pokkalla, Harsha; Han, Ling; Jia, Catherine; Huss, Ryan; Chung, Chuhan; Romero Gómez, Manuel; Younossi, Zobair M. (Wiley, 2021)
BACKGROUND AND AIMS: Manual histological assessment is currently the accepted standard for diagnosing and monitoring disease ...
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Quality of Life and Coping in Nonalcoholic Fatty Liver Disease: Influence of Diabetes and Obesity

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (MDPI, 2021)
Our aim was to analyze how type 2 diabetes and obesity influence quality of life (QoL) and coping in patients with ...
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Influence of Psychological Biomarkers on Therapeutic Adherence by Patients with Non-Alcoholic Fatty Liver Disease: A Moderated Mediation Model

Funuyet Salas, Jesús; Martín Rodríguez, Agustín; Pérez San Gregorio, María de los Ángeles; Romero Gómez, Manuel (MDPI, 2021)
Our aim was to analyze whether depressive symptoms mediated the association between physical quality of life (QoL) and ...
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Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

Stephens, Camilla; Robles-Díaz, Mercedes; Medina-Caliz, Inmaculada; García-Cortés, Miren; Romero Gómez, Manuel; Rodríguez Seguel, Elisa del Pilar; Ampuero Herrojo, Javier; Delgado de la Cuesta, Juan (Elsevier Science BV, 2021)
Background & Aims Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic ...
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Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain

Romero Gómez, Manuel; Kachru, N.; Ascanio Zamorano, M.; Darba, J.; Shreay, S. (Lippincott, Williams & Wilkins, 2020)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) presents many ...
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The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Trebicka, Jonel; Fernández, Javier; Papp, Maria; Caraceni, Paolo; Laleman, Win; Gambino, Carmine; Romero Gómez, Manuel; Arroyo, Vicente (Elsevier, 2020)
Herein, we describe, for the first time, 3 different clinical courses of acute decompensation (AD) of cirrhosis after ...
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Stratification of patients in NASH clinical trials: a pitfall for trial success

Ampuero Herrojo, Javier; Romero Gómez, Manuel (Elsevier, 2020)
Identifying the most effective therapeutic intervention in patients with NAFLD is challenging. Precise stratification in ...
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The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease

Hardy, Timothy; Wonders, Kristy; Younes, Ramy; Aithal, Guruprasad P.; Aller, Rocio; Allison, Michael; Romero Gómez, Manuel; Anstee, Quentin M. (Elsevier, 2020)
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 ...
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Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Trebicka, Jonel; Gu, Wenyi; Ibáñez-Samaniego, Luis; Hernández-Gea, Virginia; Pitarch, Carla; Garcia, Elisabet; Romero Gómez, Manuel; Bañares, Rafael (Elsevier, 2020)
Background & Aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is ...
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Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice

Perdomo, Carolina; D'Ingianna, Paola; Escalada, Javier; Petta, Salvatore; Romero Gómez, Manuel; Ampuero Herrojo, Javier (Medycyna Praktyczna, 2020)
Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that encompasses various forms of liver damage not caused ...
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A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe

Lazarus, Jeffrey V.; Ekstedt, Mattias; Marchesini, Giulio; Mullen, Jillian; Novak, Katja; Pericàs, Juan M.; Romero Gómez, Manuel; Anstee, Quentin M. (Elsevier, 2020)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become ...
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Cost of non-alcoholic steatohepatitis in Europe and the USA: the GAIN study

O'Hara, Jamie; Finnegan, Alan; Dhillon, Harpal; Ruiz-Casas, Leonardo; Pedra, Gabriel; Franks, Bethany; Romero Gómez, Manuel; Anstee, Quentin M. (Elsevier BV, 2020)
Background & Aims: Non-alcoholic steatohepatitis (NASH) leads to cirrhosis and is associated with a substantial socioeco- nomic ...
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Hepatitis C virus clearance by direct-acting antivirals agents improves endothelial dysfunction and subclinical atherosclerosis: HEPCAR study

Muñoz Hernández, Rocío; Ampuero Herrojo, Javier; Millán, Raquel; Gil-Gómez, Antonio; Rojas, Ángela; Macher, Hada C.; Stiefel García-Junco, Pablo Enrique; Romero Gómez, Manuel (Wolters Kluwer, 2020)
INTRODUCTION: Hepatitis C virus (HCV) infection has been related to increased cardiovascular (CV) risk. The aim of this ...
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Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (Frontiers Media, 2020)
Background: It is unknown how perceived social support and the progression of liver damage influence the psychosocial ...
PhD Thesis
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Genes y encefalopatía hepática: propuesta de una huella genética para la valoración del riesgo

Gil Gómez, Antonio; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2019)
Introducción y objetivos: Determinar el impacto de los factores genéticos en el desarrollo de encefalopatía hepática (EH) ...
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A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

El Sharkawy, Rasha; Bayoumi, Ali; Metwally, Mayada; Mangia, Alessandra; Ryberg, Thomas; Romero Gómez, Manuel; Eslam, Mohammed (Nature Research, 2019)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 ...
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Analysis of the burden and variability in the management of NAFLD patients in the clinical practice: unifying the required criteria

Sánchez-Torrijos, Yolanda; Ampuero Herrojo, Javier; Pérez Palacios, Domingo; Gallego Durán, Rocío; Romero Gómez, Manuel (Sociedad Española de Patología Digestiva, 2019)
Aim: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in the gastroenterology outpatient clinic and ...
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Usefulness of bioelectrical impedance analysis for monitoring patients with refractory ascites

Romero Gómez, Manuel; Ontanilla-Clavijo, Guillermo; Ampuero Herrojo, Javier; Borreguero, Samuel; Rosell, Javier (Sociedad Española de Patología Digestiva, 2019)
Background: bioelectrical impedance analysis is a technique for the determination of the hydropic component. The hydropic ...
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Relationship Between Self-Perceived Health, Vitality, and Posttraumatic Growth in Liver Transplant Recipients

Funuyet Salas, Jesús; Martín Rodríguez, Agustín; Borda Mas, María de las Mercedes; Avargues Navarro, María Luisa; Gómez Bravo, Miguel Ángel; Romero Gómez, Manuel; Conrad, Rupert; Pérez San Gregorio, María de los Ángeles (Frontiers Media, 2019)
Our objective was to analyze the differences in posttraumatic growth in 240 liver transplant recipients based on two ...
PhD Thesis
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Utilidad de la sobrecarga oral de glutamina en la predicción del riesgo y del tipo de encefalopatía hepática.

Viloria Peñas, María del Mar; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2018)
La encefalopatía hepática (EH) es un síndrome neuropsiquiátrico complejo potencialmente reversible que se produce en ...
PhD Thesis
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El antígeno de células neoplásicas escamosas (SCCA) solo o formando el complejo SCCA-igM es un biomarcador precoz de carcinoma hepatocelular.

Liu, Changhai; Ampuero Herrojo, Javier; Romero Gómez, Manuel (2018)
Background: Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and is a major health problem. ...
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New therapeutic perspectives in non-alcoholic steatohepatitis

Ampuero Herrojo, Javier; Sánchez-Torrijos, Yolanda; Aguilera, Virginia; Bellido, Francisco; Romero Gómez, Manuel (Elsevier, 2018)
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able ...
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Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

Gil Gómez, Antonio; Gómez-Sotelo, Ana Isabel; Ranchal Illescas, Isidora; Rojas Álvarez, M. Ángeles de; García-Valdecasas Merino, Marta María; Muñoz Hernández, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Sociedad Española de Patología Digestiva, 2018)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: ...
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Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy

Campo, José Antonio del; García Valdecasas, Marta; Gil Gómez, Antonio; Rojas Alvarez-Ossorio, M. Angeles; Gallego, Paloma; Ampuero Herrojo, Javier; Gallego Durán, Rocío; Pastor, Helena; Grande, Lourdes; Padillo Ruiz, Francisco Javier; Muntané Relat, Jordi; Romero Gómez, Manuel (2018)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) ...
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Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype

Rojas, Ángela; Gallego, Paloma; Gil Gómez, Antonio; Muñoz Hernández, Rocío; Martín, Lourdes; Gallego Durán, Rocío; García Valdecasas, Marta; Campo, José A. del; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (Elsevier, 2018)
Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we ...
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miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis

Liu, Chang Hai; Ampuero Herrojo, Javier; Gil Gómez, Antonio; Montero-Vallejo, Rocío; Rojas, Ángela; Muñoz Hernández, Rocío; Gallego-Durán, Rocío; Romero Gómez, Manuel (Elsevier, 2018)
Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver disease (NAFLD) and have been proposed ...
PhD Thesis
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Non-invasive diagnosis of non-alcoholic fatty liver disease.

Gallego Durán, Rocío; Romero Gómez, Manuel (2017)
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist ...
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Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results

Argüelles Arias, Federico; Guerra Veloz, María Fernanda; Perea Amarillo, Raúl; Vilches Arenas, Ángel; Castro Laria, Luisa; Maldonado Pérez, Belén; Merino Bohórquez, Vicente; Romero Gómez, Manuel (Lippincott Williams & Wilkins, 2017)
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory ...
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Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets

Rojas, Ángela; Campo, José Antonio del; Clement, Sophie; Lemasson, Mathieu; García Valdecasas, Marta; Romero Gómez, Manuel (PMC, 2016)
Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact ...
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Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis

Sendra, Carmen; Ampuero Herrojo, Javier; Giráldez Gallego, Álvaro; Sousa, José Manuel; Romero Gómez, Manuel (Thieme Medical Publishers, 2016)
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized ...
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A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin

Asselah, Tarik; Thompson, Ale J.; Flisiak, Robert; Romero Gómez, Manuel; Messinger, Diethelm; Bakalos, Georgios; Shiffman, Mitchell L. (2016)
Background Access to direct-acting antiviral agents (DAAs) is restricted in some settings; thus, the Euro pean Association ...
PhD Thesis
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Impacto de la realización de sesiones interniveles en la detección, diagnóstico y tratamiento de la hepatitis B

Otero Fernández, María Ángeles; Romero Gómez, Manuel (2016)
Objetivos: Conocer el impacto de la realización de sesiones interniveles entre atención primaria y atención hospitalaria ...
Patent. Invention
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Métodos de análisis óptico computarizado de imágenes de MR (resonancia magnética) para cuantificar o determinar lesiones hepáticas

Gallego Durán, Rocío; Cerro Salido, Pablo; Romero Gómez, Manuel; Gómez-González, Emilio (Oficina Española de Patentes y Marcas , 2016)
Método no invasivo para cuantificar las lesiones del hígado de un sujeto que se sospecha que padece una esteatosis hepática ...
PhD Thesis
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Papel de la vía de señalización de la insulina y mTOR en la infección por el virus de la Hepatitis C. Implicación en el desarrollo de carcinoma hepatocelular

García-Valdecasas Merino, Marta María; Campo Castillo, José Antonio del; Romero Gómez, Manuel (2016)
Introducción El virus de la hepatitis C (VHC) promueve resistencia a la insulina (RI) y el desarrollo de esteatosis. Al ...
PhD Thesis
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Diabetes mellitus: impact on the pathophysiology, diagnose and treatment of the hepatic encephalopathy.

Ampuero Herrojo, Javier; Romero Gómez, Manuel (2015)
Encefalopatía hepática La encefalopatía hepática (EH) es un disturbio potencialmente reversible, de causa metabólica, que ...
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Síndrome LPAC secundario a deleción del exón 4 del gen ABCB4 en un paciente con hepatitis C

Fombuena, Blanca; Ampuero Herrojo, Javier; Álvarez, Luis; Aparcero López, Reyes; Llorca, Rocío; Millán, Raquel; Pastor Ramírez, Helena; Andueza, Sara; Barbu, Veronique; Romero Gómez, Manuel (Arán Ediciones, S. L., 2014)
El síndrome LPAC (low-phospholipid-associated cholelithiasis syndrome) está asociado a mutaciones del gen ABCB4, que ...
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La poliquistosis hepática del adulto (PHA) en España: análisis de una encuesta estructurada analizando la experiencia y actitud de los especialistas de digestivo españoles

Ampuero Herrojo, Javier; Bañales, Jesús M.; Soriano, Germán; Crespo, Javier; Olcoz, José Luis; Diago, Moisés; Calleja, José L.; Romero Gómez, Manuel (Arán Ediciones, S. L, 2014)
Antecedentes: la poliquistosis hepática del adulto (PHA) es una enfermedad rara caracterizada por el engrandecimiento ...
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Hypoxic hepatitis as diabetic ketoacidosis complication

Ampuero Herrojo, Javier; Suárez-García, Emilio; Millán, Marina; Romero Gómez, Manuel (Arán Ediciones, S. L., 2014)
Hypoxic hepatitis (HH) (also known as ischemic hepatitis or shock liver) is characterized by a dramatic but transient ...
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy

Iglesias Guerra, Fernando; Díaz Herrero, María del Mar; Campo, José Antonio del; Carbonero Aguilar, María del Pilar; Vega Pérez, José Manuel; Periñán Domínguez, Ignacio; Miñano Sánchez, Javier; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (Public Library of Science, 2014)
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity ...
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Hepatobiliary manifestations in inflammatory bowel disease: The gut, the drugs and the liver

Rojas Feria, María; Romero Gómez, Manuel; Castro Fernández, Manuel; Suárez, Emilio; Ampuero Herrojo, Javier (2013)
Patent. Invention
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Uso del compuesto N-fenil-N-(3-metil-2-butenil)tiourea para la elaboración de medicamentos destinados al tratamiento de la encefalopatía hepática

Romero Gómez, Manuel; Bautista Palomas, Juan Dionisio; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Periñán Domínguez, Ignacio; Díaz Herrero, María del Mar; Jover Cobos, María (Oficina Española de Patentes y Marcas (OEPM), 2012)
La presente invención se refiere a una composición farmacéutica que comprende el compuesto N-fenil-N- (3-metil-2-butenil)tiourea ...
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Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

Barr, J; Caballería, J; Martínez Arranz, Ibon; Domínguez-Díez, A; Alonso, C; Muntané Relat, Jordi; Romero Gómez, Manuel; Moto, J.M. (2012)
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to ...
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy

Bautista Palomas, Juan Dionisio; Campo Castillo, José Antonio del; Romero Gómez, Manuel; Ranchal Illescas, Isidora; Camacho Benítez, Inés; Nuñez Hospital, David; Díaz Herrero, María del Mar; Rojas, Ángela; Maraver Zamora, Marta; Ampuero Herrojo, Javier; Figueruela, Blanca (2012)
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective ...
PhD Thesis
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Estudio de la oxidación de proteínas en ratas con encefalopatía hepática: una aproximación proteómica

Carbonero Aguilar, María del Pilar; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (2012)
En esta Tesis se ha estudiado el efecto del estrés oxidativo inducido por un estado de hiperamonemia, utilizando como ...
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Experimental models for hepatic encephalopathy

Galindo Galindo, Antonio Jesús; Jover Cobos, María; Campo Castillo, José Antonio del; Díaz Gómez, Daniel; Romero Gómez, Manuel (2011)
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Cronkhite-Canada syndrome: a new case report of this enigmatic and infrequent disease

Romero Gómez, Manuel; García, D.; Martínez García, R.; Pinto Morales, W.; Maraver Zamora, Marta; Castro Fernández, Manuel; Sánchez Muñoz, Diego (2010)
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Efficacy of triple therapy with a proton pump inhibitor, levofloxacin, and amoxicillin as first-line treatment to eradicate helicobacter pylori

Pérez Pastor, Ángeles; Romero Gómez, Manuel; Vargas Romero, Julio; Castro Fernández, Manuel; Aparcero López, Reyes; Lamas, E.; Larraona, J.; Pabón, M. (2009)
PhD Thesis
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Aproximación proteómica cuantitativa del enterocito y su relación con la encefalopatía hepática

Collantes de Terán, Laura; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (2008)
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Hepatitis C: crioglobulinemia y linfoma no-Hodgkin

Romero Gómez, Manuel (2008)
La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, ...
PhD Thesis
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Papel del IGF-1 en la patogenia de la encefalopatía hepática estudio experimental en ratas sometidas a derivación porto-cava

Díaz Gómez, Daniel; Ortega Beviá, José María; Romero Gómez, Manuel (2008)
La hepatopatía crónica (HC) se define como la inflamación del hígado de duración superior a seis meses, que se suele ...
PhD Thesis
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Papel de la hiperamoniemia sobre la actividad glutaminasa en diferentes tejidos y estrés oxidativo en ratas sometidas a derivación porto-cava

Jover Cobos, María; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (2006)
Como se sabe a partir de los datos publicados, el amonio es el principal causante de la Encefalopatía Hepática (EH). La ...
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Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

Romero Gómez, Manuel; Jover Cobos, María; Díaz Gómez, Daniel; Collantes de Terán, Laura; Rodrigo, Regina; Camacho Benítez, Inés; Echevarría, Miriam; Felipo, Vicente; Bautista Palomas, Juan Dionisio (World Journal of Gastroenterology, 2006)
AIM: To assess whether portacaval anastomosis (PCA) in rats affects the protein expression and/or activity of glutaminase ...
PhD Thesis
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Valor del diagnóstico por imagen en el estudio de la fibrosis hepática en pacientes con vhc crónica.

Luque Ordoñez, J.A.; Gómez-González, Emilio; Sabaté Diaz, Juan; Romero Gómez, Manuel (2006)
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PhD Thesis
PhD Thesis
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Papel de la glutaminasa fosfato dependiente (EC 3.5.1.2) en la patogenia de la Encefalopatía Hepática

Ramos Guerrero, Rosa María; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (2004)
PhD Thesis
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Encefalopatía hepática subclínica: valoración de diferentes métodos diagnósticos y su relación con la fisiopatología

Romero Gómez, Manuel; Aguilar Reina, José (1996)
La encefalopatía hepática subclínica (EHS) es una nueva forma de encefalopatía hepática, diferente del grado cero de ...