Data

NameRomero Gómez, Manuel
DepartmentMedicina
Knowledge areaMedicina
Professional categoryCatedrático de Universidad (Pza. V.)
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  Statistics

  • Items

    51

  • Visits

    6841

  • Downloads

    14106

  Publications

 

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A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Guo, Feifei; Estévez-Vázquez, Esther; Benedé-Ubieto, Raquel; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Nevzorova, Yulia A. (2021-12-31)
Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular ...
PhD Thesis
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Papel de los microARNs en el diagnóstico del carcinoma hepatocelular relacionado con el virus de la hepatitis B y su papel en la regulación del ADN circular covalente cerrado en pacientes con hepatitis B crónica en la zona gris

Romero Gómez, Manuel; Gil Gómez, Antonio; Zhang, Wenting (2021-11-22)
Antecedentes: La infección por el virus de la hepatitis B (VHB) sigue siendo un problema de salud pública mundial, destacando ...
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Implementing personalized medicine in covid-19 in andalusia: an opportunity to transform the healthcare system

Dopazo, Joaquín; Maya-Miles, Douglas; García, Federico; Lorusso, Nicola; Calleja, Miguel Ángel; Pareja, María Jesús; López-Miranda, José; Rodríguez-Baño, Jesús; Padillo Ruiz, Francisco Javier; Romero Gómez, Manuel (MDPI, 2021-05-26)
The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the ...
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Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects

Ampuero Herrojo, Javier; Aller, Rocío; Gallego-Durán, Rocío; Crespo, Javier; Abad, Javier; Romero Gómez, Manuel (2021-04-01)
Background and Aim: Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) ...
PhD Thesis
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Vasodilatadores arteriales versus venosos en el edema pulmonar agudo con hipertensión arterial en emergencias prehospitalarias

Romero Gómez, Manuel; Pujol de la Llave, Emilio; Gómez Izquierdo, Francisco Javier (2021-02-26)
La combinación de diuréticos, vasodilatadores venosos y morfina, constituye el tratamientohabitual de los pacientes con ...
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Quality of Life and Coping in Nonalcoholic Fatty Liver Disease: Influence of Diabetes and Obesity

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (MDPI, 2021-01-01)
Our aim was to analyze how type 2 diabetes and obesity influence quality of life (QoL) and coping in patients with ...
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Influence of Psychological Biomarkers on Therapeutic Adherence by Patients with Non-Alcoholic Fatty Liver Disease: A Moderated Mediation Model

Funuyet Salas, Jesús; Martín Rodríguez, Agustín; Pérez San Gregorio, María de los Ángeles; Romero Gómez, Manuel (MDPI, 2021-01-01)
Our aim was to analyze whether depressive symptoms mediated the association between physical quality of life (QoL) and ...
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Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients

Gil Gómez, Antonio; Rojas, Ángela; Gallego-Durán, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel; Pontisso, Patrizia; Liu, Changhai (BAISHIDENG PUBLISHING GROUP INC, 2021-01-01)
BACKGROUND The combination of alpha-fetoprotein (AFP) and squamous cell carcinoma antigen immunocomplex (SCCA-IgM) have ...
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Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Picchio, Camila A; Lens, Sabela; Hernandez-Guerra, Manuel; Arenas, Juan; Andrade, Raúl J.; Crespo, Javier; Romero Gómez, Manuel; Lazarus, Jeffrey V. (Nature Publishing Group, 2021-01-01)
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after ...
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acNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study

Wu, Xi Xi; Zheng, Kenneth I.; Boursier, Jérôme; Chan, Wah Kheong; Yilmaz, Yusuf; Romero Gómez, Manuel; Zheng, Ming Hua (EClinicalMedicine, 2021-01-01)
Background There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in ...
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Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

Funuyet Salas, Jesús; Pérez San Gregorio, María de los Ángeles; Martín Rodríguez, Agustín; Romero Gómez, Manuel (Frontiers Media, 2020-01-01)
Background: It is unknown how perceived social support and the progression of liver damage influence the psychosocial ...
PhD Thesis
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Genes y encefalopatía hepática: propuesta de una huella genética para la valoración del riesgo

Ampuero Herrojo, Javier; Romero Gómez, Manuel; Gil Gómez, Antonio (2019-06-06)
Introducción y objetivos: Determinar el impacto de los factores genéticos en el desarrollo de encefalopatía hepática (EH) ...
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A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

El Sharkawy, Rasha; Bayoumi, Ali; Metwally, Mayada; Mangia, Alessandra; Ryberg, Thomas; Romero Gómez, Manuel; Eslam, Mohammed (Nature Research, 2019-02-05)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 ...
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Analysis of the burden and variability in the management of NAFLD patients in the clinical practice: unifying the required criteria

Sánchez-Torrijos, Yolanda; Ampuero Herrojo, Javier; Pérez Palacios, Domingo; Gallego-Durán, Rocío; Romero Gómez, Manuel (Sociedad Española de Patología Digestiva, 2019-01-01)
Aim: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in the gastroenterology outpatient clinic and ...
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Relationship Between Self-Perceived Health, Vitality, and Posttraumatic Growth in Liver Transplant Recipients

Funuyet Salas, Jesús; Martín Rodríguez, Agustín; Borda Mas, María de las Mercedes; Avargues Navarro, María Luisa; Gómez Bravo, Miguel Ángel; Romero Gómez, Manuel; Conrad, Rupert; Pérez San Gregorio, María de los Ángeles (Frontiers Media, 2019-01-01)
Our objective was to analyze the differences in posttraumatic growth in 240 liver transplant recipients based on two ...
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Usefulness of bioelectrical impedance analysis for monitoring patients with refractory ascites

Romero Gómez, Manuel; Ontanilla-Clavijo, Guillermo; Ampuero Herrojo, Javier; Borreguero, Samuel; Rosell, Javier (Sociedad Española de Patología Digestiva, 2019-01-01)
Background: bioelectrical impedance analysis is a technique for the determination of the hydropic component. The hydropic ...
PhD Thesis
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Utilidad de la sobrecarga oral de glutamina en la predicción del riesgo y del tipo de encefalopatía hepática.

Ampuero Herrojo, Javier; Romero Gómez, Manuel; Viloria Peñas, María del Mar (2018-12-12)
La encefalopatía hepática (EH) es un síndrome neuropsiquiátrico complejo potencialmente reversible que se produce en ...
PhD Thesis
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El antígeno de células neoplásicas escamosas (SCCA) solo o formando el complejo SCCA-igM es un biomarcador precoz de carcinoma hepatocelular.

Ampuero Herrojo, Javier; Romero Gómez, Manuel; Liu, Changhai (2018-07-11)
Background: Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and is a major health problem. ...
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New therapeutic perspectives in non-alcoholic steatohepatitis

Ampuero Herrojo, Javier; Sánchez-Torrijos, Yolanda; Aguilera, Virginia; Bellido, Francisco; Romero Gómez, Manuel (Elsevier, 2018-02-23)
Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able ...
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Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

Gil Gómez, Antonio; Gómez-Sotelo, Ana Isabel; Ranchal Illescas, Isidora; Rojas Álvarez, M. Ángeles de; García-Valdecasas Merino, Marta María; Muñoz Hernández, Rocío; Ampuero Herrojo, Javier; Romero Gómez, Manuel (Sociedad Española de Patología Digestiva, 2018-02-01)
Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: ...
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Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy

Campo, José Antonio del; García Valdecasas, Marta; Gil Gómez, Antonio; Rojas Alvarez-Ossorio, M. Angeles; Gallego, Paloma; Ampuero Herrojo, Javier; Gallego Durán, Rocío; Pastor, Helena; Grande, Lourdes; Padillo Ruiz, Francisco Javier; Muntané Relat, Jordi; Romero Gómez, Manuel (2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) ...
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Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype

Rojas, Ángela; Gallego, Paloma; Gil Gómez, Antonio; Muñoz Hernández, Rocío; Martín, Lourdes; Gallego Durán, Rocío; García Valdecasas, Marta; Campo, José A. del; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (Elsevier, 2018-01-01)
Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we ...
PhD Thesis
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Non-invasive diagnosis of non-alcoholic fatty liver disease.

Romero Gómez, Manuel; Gallego-Durán, Rocío (2017-09-26)
Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepato-gastroenterologist ...
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Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results

Argüelles Arias, Federico; Guerra Veloz, María Fernanda; Perea Amarillo, Raúl; Vilches Arenas, Ángel; Castro Laria, Luisa; Maldonado Pérez, Belén; Merino Bohórquez, Vicente; Romero Gómez, Manuel (Lippincott Williams & Wilkins, 2017-01-01)
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory ...
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Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets

Rojas, Ángela; Campo, José Antonio del; Clement, Sophie; Lemasson, Mathieu; García Valdecasas, Marta; Romero Gómez, Manuel (PMC, 2016-08-22)
Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact ...
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Case Report: Acute-on-Chronic Liver Failure: Making the Diagnosis between Infection and Acute Alcoholic Hepatitis

Sendra, Carmen; Ampuero Herrojo, Javier; Giráldez Gallego, Álvaro; Sousa, José Manuel; Romero Gómez, Manuel (Thieme Medical Publishers, 2016-06-01)
Acute-on-chronic liver failure (ACLF) represents a reversible syndrome associated with high short-term mortality, characterized ...
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A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin

Asselah, Tarik; Thompson, Ale J.; Flisiak, Robert; Romero Gómez, Manuel; Messinger, Diethelm; Bakalos, Georgios; Shiffman, Mitchell L. (2016-03-18)
Background Access to direct-acting antiviral agents (DAAs) is restricted in some settings; thus, the Euro pean Association ...
PhD Thesis
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Impacto de la realización de sesiones interniveles en la detección, diagnóstico y tratamiento de la hepatitis B

Romero Gómez, Manuel; Otero Fernández, María Ángeles (2016-03-18)
Objetivos: Conocer el impacto de la realización de sesiones interniveles entre atención primaria y atención hospitalaria ...
PhD Thesis
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Papel de la vía de señalización de la insulina y mTOR en la infección por el virus de la Hepatitis C. Implicación en el desarrollo de carcinoma hepatocelular

Campo Castillo, José Antonio del; Romero Gómez, Manuel; García-Valdecasas Merino, Marta María (2016-02-15)
Introducción El virus de la hepatitis C (VHC) promueve resistencia a la insulina (RI) y el desarrollo de esteatosis. Al ...
PhD Thesis
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Diabetes mellitus: impact on the pathophysiology, diagnose and treatment of the hepatic encephalopathy.

Romero Gómez, Manuel; Ampuero Herrojo, Javier (2015-01-09)
Encefalopatía hepática La encefalopatía hepática (EH) es un disturbio potencialmente reversible, de causa metabólica, que ...
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La poliquistosis hepática del adulto (PHA) en España: análisis de una encuesta estructurada analizando la experiencia y actitud de los especialistas de digestivo españoles

Ampuero Herrojo, Javier; Bañales, Jesús M.; Soriano, Germán; Crespo, Javier; Olcoz, José Luis; Diago, Moisés; Calleja, José L.; Romero Gómez, Manuel (Arán Ediciones, S. L, 2014-01-01)
Antecedentes: la poliquistosis hepática del adulto (PHA) es una enfermedad rara caracterizada por el engrandecimiento ...
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Hypoxic hepatitis as diabetic ketoacidosis complication

Ampuero Herrojo, Javier; Suárez-García, Emilio; Millán, Marina; Romero Gómez, Manuel (Arán Ediciones, S. L., 2014-01-01)
Hypoxic hepatitis (HH) (also known as ischemic hepatitis or shock liver) is characterized by a dramatic but transient ...
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Síndrome LPAC secundario a deleción del exón 4 del gen ABCB4 en un paciente con hepatitis C

Fombuena, Blanca; Ampuero Herrojo, Javier; Álvarez, Luis; Aparcero López, Reyes; Llorca, Rocío; Millán, Raquel; Pastor Ramírez, Helena; Andueza, Sara; Barbu, Veronique; Romero Gómez, Manuel (Arán Ediciones, S. L., 2014-01-01)
El síndrome LPAC (low-phospholipid-associated cholelithiasis syndrome) está asociado a mutaciones del gen ABCB4, que ...
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THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy

Iglesias Guerra, Fernando; Díaz Herrero, María del Mar; Campo, José Antonio del; Carbonero Aguilar, María del Pilar; Vega Pérez, José Manuel; Periñán Domínguez, Ignacio; Miñano Sánchez, Javier; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (Public Library of Science, 2014-01-01)
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity ...
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Hepatobiliary manifestations in inflammatory bowel disease: The gut, the drugs and the liver

Rojas Feria, María; Romero Gómez, Manuel; Castro Fernández, Manuel; Suárez, Emilio; Ampuero Herrojo, Javier (2013-01-01)
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Metformin inhibits glutaminase activity and protects against hepatic encephalopathy

Bautista Palomas, Juan Dionisio; Campo Castillo, José Antonio del; Romero Gómez, Manuel; Ranchal Illescas, Isidora; Camacho Benítez, Inés; Nuñez Hospital, David; Díaz Herrero, María del Mar; Rojas, Ángela; Maraver Zamora, Marta; Ampuero Herrojo, Javier; Figueruela, Blanca (2012-01-01)
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective ...
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Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression

Barr, J; Caballería, J; Martínez Arranz, Ibon; Domínguez-Díez, A; Alonso, C; Muntané Relat, Jordi; Romero Gómez, Manuel; Moto, J.M. (2012-01-01)
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to ...
PhD Thesis
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Estudio de la oxidación de proteínas en ratas con encefalopatía hepática: una aproximación proteómica

Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel; Carbonero Aguilar, María del Pilar (2012-01-01)
En esta Tesis se ha estudiado el efecto del estrés oxidativo inducido por un estado de hiperamonemia, utilizando como ...
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Experimental models for hepatic encephalopathy

Galindo Galindo, Antonio Jesús; Jover Cobos, María; Campo Castillo, José Antonio del; Díaz Gómez, Daniel; Romero Gómez, Manuel (2011-01-01)
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Cronkhite-Canada syndrome: a new case report of this enigmatic and infrequent disease

Romero Gómez, Manuel; García, D.; Martínez García, R.; Pinto Morales, W.; Maraver Zamora, Marta; Castro Fernández, Manuel; Sánchez Muñoz, Diego (2010-01-01)
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Efficacy of triple therapy with a proton pump inhibitor, levofloxacin, and amoxicillin as first-line treatment to eradicate helicobacter pylori

Pérez Pastor, Ángeles; Romero Gómez, Manuel; Vargas Romero, Julio; Castro Fernández, Manuel; Aparcero López, Reyes; Lamas, E.; Larraona, J.; Pabón, M. (2009-01-01)
PhD Thesis
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Aproximación proteómica cuantitativa del enterocito y su relación con la encefalopatía hepática

Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel; Collantes de Terán, Laura (2008-01-20)
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Hepatitis C: crioglobulinemia y linfoma no-Hodgkin

Romero Gómez, Manuel (2008-01-01)
La infección por el virus de la hepatitis C juega un papel principal en la patogénesis de la crioglobulinemia mixta, ...
PhD Thesis
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Papel del IGF-1 en la patogenia de la encefalopatía hepática estudio experimental en ratas sometidas a derivación porto-cava

Ortega Beviá, José María; Romero Gómez, Manuel; Díaz Gómez, Daniel (2008-01-01)
La hepatopatía crónica (HC) se define como la inflamación del hígado de duración superior a seis meses, que se suele ...
PhD Thesis
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Papel de la hiperamoniemia sobre la actividad glutaminasa en diferentes tejidos y estrés oxidativo en ratas sometidas a derivación porto-cava

Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel; Jover Cobos, María (2006-12-21)
Como se sabe a partir de los datos publicados, el amonio es el principal causante de la Encefalopatía Hepática (EH). La ...
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Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis

Romero Gómez, Manuel; Jover Cobos, María; Díaz Gómez, Daniel; Collantes de Terán, Laura; Rodrigo, Regina; Camacho Benítez, Inés; Echevarría, Miriam; Felipo, Vicente; Bautista Palomas, Juan Dionisio (World Journal of Gastroenterology, 2006-04-21)
AIM: To assess whether portacaval anastomosis (PCA) in rats affects the protein expression and/or activity of glutaminase ...
PhD Thesis
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Valor del diagnóstico por imagen en el estudio de la fibrosis hepática en pacientes con vhc crónica.

Gómez-González, Emilio; Sabaté Diaz, Juan; Romero Gómez, Manuel; Luque Ordoñez, J.A. (2006-02-20)
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Hepatitis C: are there any options for non-responders?

Romero Gómez, Manuel (2005-01-01)
PhD Thesis
PhD Thesis
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Papel de la glutaminasa fosfato dependiente (EC 3.5.1.2) en la patogenia de la Encefalopatía Hepática

Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel; Ramos Guerrero, Rosa María (2004-04-14)
PhD Thesis
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Encefalopatía hepática subclínica: valoración de diferentes métodos diagnósticos y su relación con la fisiopatología

Aguilar Reina, José; Romero Gómez, Manuel (1996-02-05)
La encefalopatía hepática subclínica (EHS) es una nueva forma de encefalopatía hepática, diferente del grado cero de ...