Article
Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation
Author/s | Rey, E.
Ampuero Herrojo, Javier ![]() ![]() ![]() ![]() ![]() ![]() ![]() Molina-Jiménez, F. García-García, Y. Muñoz Hernández, Rocío ![]() ![]() ![]() ![]() ![]() ![]() Romero Gómez, Manuel ![]() ![]() ![]() ![]() ![]() ![]() ![]() García-Monzón, C. Majano, P. González-Rodríguez, A. |
Department | Universidad de Sevilla. Departamento de Medicina |
Date | 2021-01-12 |
Published in |
|
Abstract | In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in hepatitis C virus (HCV)-patients, and, for the first
time, revealed which molecular mechanisms are ... In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in hepatitis C virus (HCV)-patients, and, for the first time, revealed which molecular mechanisms are involved in SOF effects on the impaired insulin response induced by HCV in hepatocytes. |
Funding agencies | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Project ID. | PI16/00823
![]() PI17/0535 ![]() PI17/0008 ![]() |
Citation | Rey, E., Ampuero Herrojo, J., Molina-Jiménez, F., García-García, Y., Muñoz Hernández, R., Romero Gómez, M.,...,González-Rodríguez, A. (2021). Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation. Clinical and translational medicine, 11 (1), e275. https://doi.org/10.1002/ctm2.275. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Sofosbuvir...pdf | 1.688Mb | ![]() | View/ | |