Artículo
Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD)
Autor/es | Fernández Rodríguez, Conrado M.
Aller, Rocío Gutiérrez García, María Luisa Ampuero Herrojo, Javier Gómez-Camarero, Judith Martín-Mateos, Rosa M.ª Romero Gómez, Manuel |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2019 |
Fecha de depósito | 2024-05-14 |
Publicado en |
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Resumen | Background: recent evidence suggests a causal link
between serum uric acid and the metabolic syndrome, dia
betes me llitus, arterial hypertension, and renal and cardiac
disease. Uric acid is an endogenous danger signal ... Background: recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, dia betes me llitus, arterial hypertension, and renal and cardiac disease. Uric acid is an endogenous danger signal and acti vator of the inflammasome, and has been independently associated with an increased risk of cirrhosis. Aim and methods: six hundred and thirty-four patients from the nation-wide HEPAMET registry with biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuri cemia is related with advanced liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Patients were divid ed into three groups according to the tertile levels of serum uric acid and gender. Results: the cohort was composed of 50% females, with a mean age of 49 years (range 19-80). Patients in the top third of serum uric acid levels were older (p = 0.017); they had a higher body mass index (p < 0.01), arterial blood pres sure (p = 0.05), triglyceridemia (p = 0.012), serum creatinine (p < 0.001) and total cholesterol (p = 0.016) and lower HDL-cholesterol (p = 0.004). According to the univariate analysis, the variables associated with patients in the top third were more advanced steatosis (p = 0.02), liver fibrosis (F2-F4 vs F0-1; p = 0.011), NASH (p = 0.002) and NAS score (p = 0.05). According to the multivariate logistic regression analysis, the top third of uric acid level was independently associated with steatosis (adjusted hazard ratio 1.7; CI 95%: 1.05-2.8) and NASH (adjusted hazard ratio 1.8; CI 95%: 1.08 3.0) but not with advanced fibrosis (F2-F4) (adjusted hazard ratio 1.09; CI 95%: 0.63-1.87). Conclusion: higher levels of serum uric acid were inde pendently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Serum uric acid levels warrants further evaluation as a component of the current non-invasive NAFLD scores of histopathological damage. |
Cita | Fernández Rodríguez, C.M., Aller, R., Gutiérrez García, M.L., Ampuero Herrojo, J., Gómez-Camarero, J., Martín-Mateos, R.M.ª. y Romero Gómez, M. (2019). Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). Revista Española de Enfermedades Digestivas, 111 (4), 264-269. https://doi.org/10.17235/reed.2019.5965/2018. |
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