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Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
dc.creator | Gómez González, Belén | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2023-10-20T15:45:17Z | |
dc.date.available | 2023-10-20T15:45:17Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Gómez González, B. y Aguilera López, A. (2023). Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?. EMBO Reports, e57801. https://doi.org/10.15252/embr.202357801. | |
dc.identifier.issn | 1469-221X | es |
dc.identifier.issn | 1469-3178 | es |
dc.identifier.uri | https://hdl.handle.net/11441/149822 | |
dc.description.abstract | Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially repaired by non-homologous end joining or homologous recombination (HR). In recent years, numerous reports have revealed that DSBs enhance DNA–RNA hybrid formation around the break site. We call these hybrids “break-induced RNA–DNA hybrids” (BIRDHs) to differentiate them from sporadic R-loops consisting of DNA–RNA hybrids and a displaced single-strand DNA occurring co-transcriptionally in intact DNA. Here, we review and discuss the most relevant data about BIRDHs, with a focus on two main questions raised: (i) whether BIRDHs form by de novo transcription after a DSB or by a pre-existing nascent RNA in DNA regions undergoing transcription and (ii) whether they have a positive role in HR or are just obstacles to HR accidentally generated as an intrinsic risk of transcription. We aim to provide a comprehensive view of the exciting and yet unresolved questions about the source and impact of BIRDHs in the cell. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-104270GB-I00/BMC | es |
dc.format | application/pdf | es |
dc.format.extent | 17 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | EMBO Reports, e57801. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DNA damage | es |
dc.subject | DNA–RNA hybrids | es |
dc.subject | DSBs | es |
dc.subject | Recombination | es |
dc.subject | Repair | es |
dc.title | Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe? | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | PID2019-104270GB-I00/BMC | es |
dc.relation.publisherversion | https://doi.org/10.15252/embr.202357801 | es |
dc.identifier.doi | 10.15252/embr.202357801 | es |
dc.journaltitle | EMBO Reports | es |
dc.publication.initialPage | e57801 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Break-induced RNA–DNA.pdf | 1.088Mb | ![]() | Ver/ | |