Artículo
Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells
Autor/es | Tabares, Lucía
Alés González de la Higuera, Eva María Lindau, Manfred Álvarez de Toledo Naranjo, Guillermo |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Fecha de publicación | 2001-08-27 |
Fecha de depósito | 2023-05-17 |
Publicado en |
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Resumen | Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to
exocytosis, allowing rapid retrieval from the plasma
membrane of fused vesicles for future use. This can be a
much ... Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, allowing rapid retrieval from the plasma membrane of fused vesicles for future use. This can be a much faster mechanism for membrane recycling than classical clathrin-mediated endocytosis. During a fast exo-endocytotic cycle, the vesicle membrane does not fully collapse into the plasma membrane; nevertheless, it releases the vesicular contents through the fusion pore. Once the vesicle is depleted of transmitter, its membrane is recovered without renouncing its identity. In this report, we show that chromaffin cells contain catecholamine-free granules that retain their ability to fuse with the plasma membrane. These catecholaminefree granules represent 7% of the total population of fused vesicles, but they contributed to 47% of the fusion events when the cells were treated with reserpine for several hours. We propose that rat chromaffin granules that transiently fuse with the plasma membrane preserve their exocytotic machinery, allowing another round of exocytosis. |
Cita | Tabares, L., Alés González de la Higuera, E.M., Lindau, M. y Álvarez de Toledo Naranjo, G. (2001). Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells. JOURNAL OF BIOLOGICAL CHEMISTRY, 276 (43), 39974-39979. https://doi.org/10.1074/jbc.M106498200. |
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